Browse A1CF

Summary
SymbolA1CF
NameAPOBEC1 complementation factor
Aliases ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ......
Chromosomal Location10q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Nucleus Endoplasmic reticulum Cytoplasm Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1.
Domain PF00076 RNA recognition motif. (a.k.a. RRM
Function

Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay.

> Gene Ontology
 
Biological Process GO:0006397 mRNA processing
GO:0009451 RNA modification
GO:0016553 base conversion or substitution editing
GO:0016554 cytidine to uridine editing
GO:0016556 mRNA modification
GO:0031647 regulation of protein stability
GO:0050821 protein stabilization
Molecular Function GO:0003727 single-stranded RNA binding
Cellular Component GO:0030895 apolipoprotein B mRNA editing enzyme complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-75094: Formation of the Editosome
R-HSA-74160: Gene Expression
R-HSA-75072: mRNA Editing
R-HSA-72200: mRNA Editing
Summary
SymbolA1CF
NameAPOBEC1 complementation factor
Aliases ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ......
Chromosomal Location10q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between A1CF and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolA1CF
NameAPOBEC1 complementation factor
Aliases ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ......
Chromosomal Location10q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of A1CF in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolA1CF
NameAPOBEC1 complementation factor
Aliases ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ......
Chromosomal Location10q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of A1CF in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.4050.306
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)6501
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.7090.27
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.0630.905
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.50.654
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.7740.559
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1780.861
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.9990.606
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-1.0250.575
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.780.45
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.0770.953
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.5660.136
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of A1CF in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141714.3014.30.196
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103200201
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 277318.52.715.80.0147
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 01407.1-7.11
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 275918.51.716.80.0108
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.323.5-9.20.678
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)86250250.473
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.736.4-28.70.142
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.16.24.91
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 472514.310.71
1329033130MelanomaallAnti-PD-1 (nivolumab) 382710.5010.50.135
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22134.504.51
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 161418.8018.80.228
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolA1CF
NameAPOBEC1 complementation factor
Aliases ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ......
Chromosomal Location10q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of A1CF. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolA1CF
NameAPOBEC1 complementation factor
Aliases ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ......
Chromosomal Location10q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of A1CF. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by A1CF.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolA1CF
NameAPOBEC1 complementation factor
Aliases ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ......
Chromosomal Location10q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of A1CF. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolA1CF
NameAPOBEC1 complementation factor
Aliases ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ......
Chromosomal Location10q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of A1CF expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolA1CF
NameAPOBEC1 complementation factor
Aliases ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ......
Chromosomal Location10q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between A1CF and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolA1CF
NameAPOBEC1 complementation factor
Aliases ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ......
Chromosomal Location10q21.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting A1CF collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.