Summary | |
---|---|
Symbol | A1CF |
Name | APOBEC1 complementation factor |
Aliases | ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ...... |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Endoplasmic reticulum Cytoplasm Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. |
Domain |
PF00076 RNA recognition motif. (a.k.a. RRM |
Function |
Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. |
Biological Process |
GO:0006397 mRNA processing GO:0009451 RNA modification GO:0016553 base conversion or substitution editing GO:0016554 cytidine to uridine editing GO:0016556 mRNA modification GO:0031647 regulation of protein stability GO:0050821 protein stabilization |
Molecular Function |
GO:0003727 single-stranded RNA binding |
Cellular Component |
GO:0030895 apolipoprotein B mRNA editing enzyme complex |
KEGG | - |
Reactome |
R-HSA-75094: Formation of the Editosome R-HSA-74160: Gene Expression R-HSA-75072: mRNA Editing R-HSA-72200: mRNA Editing |
Summary | |
---|---|
Symbol | A1CF |
Name | APOBEC1 complementation factor |
Aliases | ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ...... |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between A1CF and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | A1CF |
Name | APOBEC1 complementation factor |
Aliases | ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ...... |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of A1CF in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | A1CF |
Name | APOBEC1 complementation factor |
Aliases | ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ...... |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of A1CF in various data sets.
|
Points in the above scatter plot represent the mutation difference of A1CF in various data sets.
|
Summary | |
---|---|
Symbol | A1CF |
Name | APOBEC1 complementation factor |
Aliases | ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ...... |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of A1CF. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | A1CF |
Name | APOBEC1 complementation factor |
Aliases | ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ...... |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of A1CF. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by A1CF. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | A1CF |
Name | APOBEC1 complementation factor |
Aliases | ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ...... |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of A1CF. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | A1CF |
Name | APOBEC1 complementation factor |
Aliases | ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ...... |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of A1CF expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | A1CF |
Name | APOBEC1 complementation factor |
Aliases | ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ...... |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between A1CF and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | A1CF |
Name | APOBEC1 complementation factor |
Aliases | ACF; ACF64; ACF65; APOBEC1CF; APOBEC-1 stimulating protein; apo-B RNA editing protein; apobec-1 complementat ...... |
Chromosomal Location | 10q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting A1CF collected from DrugBank database. |
There is no record. |