Summary | |
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Symbol | A2ML1 |
Name | alpha-2-macroglobulin-like 1 |
Aliases | FLJ25179; CPAMD9; C3 and PZP-like, alpha-2-macroglobulin domain containing 9; C3 and PZP-like alpha-2-macrog ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted |
Domain |
PF00207 Alpha-2-macroglobulin family PF07678 A-macroglobulin complement component PF01835 MG2 domain PF07703 Alpha-2-macroglobulin family N-terminal region PF07677 A-macroglobulin receptor PF10569 Alpha-macro-globulin thiol-ester bond-forming region |
Function |
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase (By similarity). Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases. |
Biological Process |
GO:0010466 negative regulation of peptidase activity GO:0010951 negative regulation of endopeptidase activity GO:0045861 negative regulation of proteolysis GO:0051346 negative regulation of hydrolase activity GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity |
Molecular Function |
GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0004867 serine-type endopeptidase inhibitor activity GO:0030414 peptidase inhibitor activity GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | A2ML1 |
Name | alpha-2-macroglobulin-like 1 |
Aliases | FLJ25179; CPAMD9; C3 and PZP-like, alpha-2-macroglobulin domain containing 9; C3 and PZP-like alpha-2-macrog ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between A2ML1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | A2ML1 |
Name | alpha-2-macroglobulin-like 1 |
Aliases | FLJ25179; CPAMD9; C3 and PZP-like, alpha-2-macroglobulin domain containing 9; C3 and PZP-like alpha-2-macrog ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of A2ML1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | A2ML1 |
Name | alpha-2-macroglobulin-like 1 |
Aliases | FLJ25179; CPAMD9; C3 and PZP-like, alpha-2-macroglobulin domain containing 9; C3 and PZP-like alpha-2-macrog ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of A2ML1 in various data sets.
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Points in the above scatter plot represent the mutation difference of A2ML1 in various data sets.
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Summary | |
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Symbol | A2ML1 |
Name | alpha-2-macroglobulin-like 1 |
Aliases | FLJ25179; CPAMD9; C3 and PZP-like, alpha-2-macroglobulin domain containing 9; C3 and PZP-like alpha-2-macrog ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of A2ML1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | A2ML1 |
Name | alpha-2-macroglobulin-like 1 |
Aliases | FLJ25179; CPAMD9; C3 and PZP-like, alpha-2-macroglobulin domain containing 9; C3 and PZP-like alpha-2-macrog ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of A2ML1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by A2ML1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | A2ML1 |
Name | alpha-2-macroglobulin-like 1 |
Aliases | FLJ25179; CPAMD9; C3 and PZP-like, alpha-2-macroglobulin domain containing 9; C3 and PZP-like alpha-2-macrog ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of A2ML1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | A2ML1 |
Name | alpha-2-macroglobulin-like 1 |
Aliases | FLJ25179; CPAMD9; C3 and PZP-like, alpha-2-macroglobulin domain containing 9; C3 and PZP-like alpha-2-macrog ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of A2ML1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | A2ML1 |
Name | alpha-2-macroglobulin-like 1 |
Aliases | FLJ25179; CPAMD9; C3 and PZP-like, alpha-2-macroglobulin domain containing 9; C3 and PZP-like alpha-2-macrog ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between A2ML1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | A2ML1 |
Name | alpha-2-macroglobulin-like 1 |
Aliases | FLJ25179; CPAMD9; C3 and PZP-like, alpha-2-macroglobulin domain containing 9; C3 and PZP-like alpha-2-macrog ...... |
Chromosomal Location | 12p13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting A2ML1 collected from DrugBank database. |
There is no record. |