Summary | |
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Symbol | AATF |
Name | apoptosis antagonizing transcription factor |
Aliases | DED; CHE-1; BFR2; apoptosis-antagonizing transcription factor; rb-binding protein Che-1; Protein AATF |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus, nucleolus |
Domain |
PF13339 Apoptosis antagonizing transcription factor PF08164 Apoptosis-antagonizing transcription factor |
Function |
May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date. |
Biological Process |
GO:0006801 superoxide metabolic process GO:0007346 regulation of mitotic cell cycle GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0010559 regulation of glycoprotein biosynthetic process GO:0010561 negative regulation of glycoprotein biosynthetic process GO:0022613 ribonucleoprotein complex biogenesis GO:0032928 regulation of superoxide anion generation GO:0032929 negative regulation of superoxide anion generation GO:0040016 embryonic cleavage GO:0042254 ribosome biogenesis GO:0042554 superoxide anion generation GO:0042982 amyloid precursor protein metabolic process GO:0042983 amyloid precursor protein biosynthetic process GO:0042984 regulation of amyloid precursor protein biosynthetic process GO:0042985 negative regulation of amyloid precursor protein biosynthetic process GO:0072593 reactive oxygen species metabolic process GO:0090322 regulation of superoxide metabolic process GO:1903018 regulation of glycoprotein metabolic process GO:1903019 negative regulation of glycoprotein metabolic process GO:2000377 regulation of reactive oxygen species metabolic process GO:2000378 negative regulation of reactive oxygen species metabolic process |
Molecular Function |
GO:0030275 LRR domain binding GO:0043522 leucine zipper domain binding GO:0048156 tau protein binding |
Cellular Component |
GO:0005813 centrosome GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0030055 cell-substrate junction |
KEGG | - |
Reactome |
R-HSA-204998: Cell death signalling via NRAGE, NRIF and NADE R-HSA-193648: NRAGE signals death through JNK R-HSA-162582: Signal Transduction R-HSA-166520: Signalling by NGF R-HSA-193704: p75 NTR receptor-mediated signalling |
Summary | |
---|---|
Symbol | AATF |
Name | apoptosis antagonizing transcription factor |
Aliases | DED; CHE-1; BFR2; apoptosis-antagonizing transcription factor; rb-binding protein Che-1; Protein AATF |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between AATF and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | AATF |
Name | apoptosis antagonizing transcription factor |
Aliases | DED; CHE-1; BFR2; apoptosis-antagonizing transcription factor; rb-binding protein Che-1; Protein AATF |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of AATF in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | AATF |
Name | apoptosis antagonizing transcription factor |
Aliases | DED; CHE-1; BFR2; apoptosis-antagonizing transcription factor; rb-binding protein Che-1; Protein AATF |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of AATF in various data sets.
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Points in the above scatter plot represent the mutation difference of AATF in various data sets.
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Summary | |
---|---|
Symbol | AATF |
Name | apoptosis antagonizing transcription factor |
Aliases | DED; CHE-1; BFR2; apoptosis-antagonizing transcription factor; rb-binding protein Che-1; Protein AATF |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AATF. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | AATF |
Name | apoptosis antagonizing transcription factor |
Aliases | DED; CHE-1; BFR2; apoptosis-antagonizing transcription factor; rb-binding protein Che-1; Protein AATF |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AATF. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AATF. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | AATF |
Name | apoptosis antagonizing transcription factor |
Aliases | DED; CHE-1; BFR2; apoptosis-antagonizing transcription factor; rb-binding protein Che-1; Protein AATF |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AATF. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | AATF |
Name | apoptosis antagonizing transcription factor |
Aliases | DED; CHE-1; BFR2; apoptosis-antagonizing transcription factor; rb-binding protein Che-1; Protein AATF |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of AATF expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | AATF |
Name | apoptosis antagonizing transcription factor |
Aliases | DED; CHE-1; BFR2; apoptosis-antagonizing transcription factor; rb-binding protein Che-1; Protein AATF |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between AATF and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | AATF |
Name | apoptosis antagonizing transcription factor |
Aliases | DED; CHE-1; BFR2; apoptosis-antagonizing transcription factor; rb-binding protein Che-1; Protein AATF |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting AATF collected from DrugBank database. |
There is no record. |