Summary | |
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Symbol | ABCA7 |
Name | ATP-binding cassette, sub-family A (ABC1), member 7 |
Aliases | ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein Golgi apparatus membrane Multi-pass membrane protein Early endosome membrane Multi-pass membrane protein Note=Localizes to cell membrane ruffles and phagocytic cups of macrophages stimulated with C1q or apoptotic cells. Localizes to the cytoplasm of resting macrophages, probably in Golgi and endosomes. Localizes to the apical brush border of cells in the proximal tubules of kidney (By similarity). Isoform 2 may localize to the endoplasmic reticulum (PubMed:14592415). |
Domain |
PF00005 ABC transporter |
Function |
Plays a role in phagocytosis by macrophages of apoptotic cells. Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. May also mediate cholesterol efflux. May regulate cellular ceramide homeostasis during keratinocytes differentiation. |
Biological Process |
GO:0006869 lipid transport GO:0006909 phagocytosis GO:0006911 phagocytosis, engulfment GO:0007611 learning or memory GO:0007613 memory GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0010324 membrane invagination GO:0010559 regulation of glycoprotein biosynthetic process GO:0010561 negative regulation of glycoprotein biosynthetic process GO:0010874 regulation of cholesterol efflux GO:0010875 positive regulation of cholesterol efflux GO:0010876 lipid localization GO:0015748 organophosphate ester transport GO:0015850 organic hydroxy compound transport GO:0015914 phospholipid transport GO:0015917 aminophospholipid transport GO:0015918 sterol transport GO:0018149 peptide cross-linking GO:0030100 regulation of endocytosis GO:0030301 cholesterol transport GO:0032368 regulation of lipid transport GO:0032370 positive regulation of lipid transport GO:0032371 regulation of sterol transport GO:0032373 positive regulation of sterol transport GO:0032374 regulation of cholesterol transport GO:0032376 positive regulation of cholesterol transport GO:0033344 cholesterol efflux GO:0033700 phospholipid efflux GO:0034204 lipid translocation GO:0034205 beta-amyloid formation GO:0034248 regulation of cellular amide metabolic process GO:0034249 negative regulation of cellular amide metabolic process GO:0034377 plasma lipoprotein particle assembly GO:0034380 high-density lipoprotein particle assembly GO:0034504 protein localization to nucleus GO:0038027 apolipoprotein A-I-mediated signaling pathway GO:0042982 amyloid precursor protein metabolic process GO:0042983 amyloid precursor protein biosynthetic process GO:0042984 regulation of amyloid precursor protein biosynthetic process GO:0042985 negative regulation of amyloid precursor protein biosynthetic process GO:0042987 amyloid precursor protein catabolic process GO:0043277 apoptotic cell clearance GO:0043410 positive regulation of MAPK cascade GO:0043652 engulfment of apoptotic cell GO:0044708 single-organism behavior GO:0045332 phospholipid translocation GO:0045807 positive regulation of endocytosis GO:0050435 beta-amyloid metabolic process GO:0050764 regulation of phagocytosis GO:0050766 positive regulation of phagocytosis GO:0050890 cognition GO:0060099 regulation of phagocytosis, engulfment GO:0060100 positive regulation of phagocytosis, engulfment GO:0060627 regulation of vesicle-mediated transport GO:0065005 protein-lipid complex assembly GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0071825 protein-lipid complex subunit organization GO:0071827 plasma lipoprotein particle organization GO:0097006 regulation of plasma lipoprotein particle levels GO:0097035 regulation of membrane lipid distribution GO:0097242 beta-amyloid clearance GO:0099024 plasma membrane invagination GO:1900221 regulation of beta-amyloid clearance GO:1900223 positive regulation of beta-amyloid clearance GO:1901074 regulation of engulfment of apoptotic cell GO:1901076 positive regulation of engulfment of apoptotic cell GO:1902003 regulation of beta-amyloid formation GO:1902430 negative regulation of beta-amyloid formation GO:1902991 regulation of amyloid precursor protein catabolic process GO:1902992 negative regulation of amyloid precursor protein catabolic process GO:1902994 regulation of phospholipid efflux GO:1902995 positive regulation of phospholipid efflux GO:1903018 regulation of glycoprotein metabolic process GO:1903019 negative regulation of glycoprotein metabolic process GO:1905153 regulation of membrane invagination GO:1905155 positive regulation of membrane invagination GO:2000425 regulation of apoptotic cell clearance GO:2000427 positive regulation of apoptotic cell clearance GO:2001138 regulation of phospholipid transport GO:2001140 positive regulation of phospholipid transport |
Molecular Function |
GO:0004012 phospholipid-translocating ATPase activity GO:0005319 lipid transporter activity GO:0005548 phospholipid transporter activity GO:0008525 phosphatidylcholine transporter activity GO:0015247 aminophospholipid transporter activity GO:0015399 primary active transmembrane transporter activity GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016887 ATPase activity GO:0022804 active transmembrane transporter activity GO:0030226 apolipoprotein receptor activity GO:0034188 apolipoprotein A-I receptor activity GO:0042623 ATPase activity, coupled GO:0042626 ATPase activity, coupled to transmembrane movement of substances GO:0043492 ATPase activity, coupled to movement of substances GO:0090554 phosphatidylcholine-translocating ATPase activity GO:0090556 phosphatidylserine-translocating ATPase activity |
Cellular Component |
GO:0001726 ruffle GO:0001891 phagocytic cup GO:0005769 early endosome GO:0010008 endosome membrane GO:0016324 apical plasma membrane GO:0031252 cell leading edge GO:0031253 cell projection membrane GO:0031256 leading edge membrane GO:0031901 early endosome membrane GO:0032587 ruffle membrane GO:0043190 ATP-binding cassette (ABC) transporter complex GO:0044440 endosomal part GO:0045177 apical part of cell GO:0098533 ATPase dependent transmembrane transport complex GO:1902495 transmembrane transporter complex GO:1904949 ATPase complex GO:1990351 transporter complex |
KEGG |
hsa02010 ABC transporters |
Reactome |
R-HSA-1369062: ABC transporters in lipid homeostasis R-HSA-382556: ABC-family proteins mediated transport R-HSA-382551: Transmembrane transport of small molecules |
Summary | |
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Symbol | ABCA7 |
Name | ATP-binding cassette, sub-family A (ABC1), member 7 |
Aliases | ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ABCA7 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ABCA7 |
Name | ATP-binding cassette, sub-family A (ABC1), member 7 |
Aliases | ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ABCA7 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ABCA7 |
Name | ATP-binding cassette, sub-family A (ABC1), member 7 |
Aliases | ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ABCA7 in various data sets.
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Points in the above scatter plot represent the mutation difference of ABCA7 in various data sets.
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Summary | |
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Symbol | ABCA7 |
Name | ATP-binding cassette, sub-family A (ABC1), member 7 |
Aliases | ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ABCA7. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ABCA7 |
Name | ATP-binding cassette, sub-family A (ABC1), member 7 |
Aliases | ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ABCA7. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ABCA7. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ABCA7 |
Name | ATP-binding cassette, sub-family A (ABC1), member 7 |
Aliases | ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ABCA7. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ABCA7 |
Name | ATP-binding cassette, sub-family A (ABC1), member 7 |
Aliases | ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ABCA7 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ABCA7 |
Name | ATP-binding cassette, sub-family A (ABC1), member 7 |
Aliases | ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ABCA7 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ABCA7 |
Name | ATP-binding cassette, sub-family A (ABC1), member 7 |
Aliases | ABCX; ABCA-SSN; autoantigen SS-N; macrophage ABC transporter; ATP-binding cassette sub-family A member 7 |
Chromosomal Location | 19p13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ABCA7 collected from DrugBank database. |
There is no record. |