Browse ABCC2

Summary
SymbolABCC2
NameATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location10q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Apical cell membrane Multi-pass membrane protein
Domain PF00664 ABC transporter transmembrane region
PF00005 ABC transporter
Function

Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.

> Gene Ontology
 
Biological Process GO:0001101 response to acid chemical
GO:0006820 anion transport
GO:0006835 dicarboxylic acid transport
GO:0006855 drug transmembrane transport
GO:0006869 lipid transport
GO:0006979 response to oxidative stress
GO:0009266 response to temperature stimulus
GO:0009408 response to heat
GO:0009914 hormone transport
GO:0010817 regulation of hormone levels
GO:0010876 lipid localization
GO:0015711 organic anion transport
GO:0015718 monocarboxylic acid transport
GO:0015723 bilirubin transport
GO:0015732 prostaglandin transport
GO:0015893 drug transport
GO:0015908 fatty acid transport
GO:0030002 cellular anion homeostasis
GO:0030320 cellular monovalent inorganic anion homeostasis
GO:0030644 cellular chloride ion homeostasis
GO:0031427 response to methotrexate
GO:0042493 response to drug
GO:0043627 response to estrogen
GO:0046685 response to arsenic-containing substance
GO:0046942 carboxylic acid transport
GO:0048545 response to steroid hormone
GO:0055064 chloride ion homeostasis
GO:0055081 anion homeostasis
GO:0055083 monovalent inorganic anion homeostasis
GO:0070327 thyroid hormone transport
GO:0071715 icosanoid transport
GO:0072337 modified amino acid transport
GO:0098656 anion transmembrane transport
Molecular Function GO:0005310 dicarboxylic acid transmembrane transporter activity
GO:0005342 organic acid transmembrane transporter activity
GO:0008509 anion transmembrane transporter activity
GO:0008514 organic anion transmembrane transporter activity
GO:0015127 bilirubin transmembrane transporter activity
GO:0015399 primary active transmembrane transporter activity
GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887 ATPase activity
GO:0022804 active transmembrane transporter activity
GO:0022853 active ion transmembrane transporter activity
GO:0042623 ATPase activity, coupled
GO:0042625 ATPase coupled ion transmembrane transporter activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0043225 ATPase-coupled anion transmembrane transporter activity
GO:0043492 ATPase activity, coupled to movement of substances
GO:0046943 carboxylic acid transmembrane transporter activity
Cellular Component GO:0016324 apical plasma membrane
GO:0045177 apical part of cell
> KEGG and Reactome Pathway
 
KEGG hsa02010 ABC transporters
hsa04976 Bile secretion
Reactome R-HSA-382556: ABC-family proteins mediated transport
R-HSA-382551: Transmembrane transport of small molecules
Summary
SymbolABCC2
NameATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location10q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ABCC2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolABCC2
NameATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location10q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ABCC2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolABCC2
NameATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location10q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ABCC2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14121.2210.0587
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)652.4720.0253
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.3030.761
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.4320.337
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-1.0690.463
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.3680.829
729033130MelanomaallAnti-PD-1 (nivolumab) 26231.6360.0242
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15111.2160.354
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11122.0240.18
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.1790.878
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 28-0.020.99
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1130.567
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ABCC2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14177.107.10.452
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 103100101
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.45.51.90.66
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.46.80.61
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47014.3-14.31
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221307.7-7.70.371
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 111307.7-7.71
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 51208.3-8.31
Summary
SymbolABCC2
NameATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location10q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ABCC2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolABCC2
NameATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location10q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ABCC2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ABCC2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolABCC2
NameATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location10q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ABCC2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolABCC2
NameATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location10q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ABCC2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolABCC2
NameATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location10q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ABCC2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolABCC2
NameATP-binding cassette, sub-family C (CFTR/MRP), member 2
Aliases DJS; cMRP; CMOAT; canalicular multispecific organic anion transporter 1; ABC30; canalicular multidrug resist ......
Chromosomal Location10q24
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ABCC2 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting ABCC2.
ID Name Drug Type Targets #Targets
DB00171ATPSmall MoleculeABCA1, ABCB1, ABCB11, ABCC1, ABCC2, ABCC4, ABCC6, ABCC8, ABCC9, AB ......42
DB01138SulfinpyrazoneSmall MoleculeABCC1, ABCC2, NR1I2, SLC22A124