Summary | |
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Symbol | ABCC8 |
Name | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 |
Aliases | SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein |
Domain |
PF00664 ABC transporter transmembrane region PF00005 ABC transporter |
Function |
Subunit of the beta-cell ATP-sensitive potassium channel (KATP). Regulator of ATP-sensitive K(+) channels and insulin release. |
Biological Process |
GO:0002237 response to molecule of bacterial origin GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0002792 negative regulation of peptide secretion GO:0006813 potassium ion transport GO:0006820 anion transport GO:0009268 response to pH GO:0009306 protein secretion GO:0009914 hormone transport GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010043 response to zinc ion GO:0010817 regulation of hormone levels GO:0010959 regulation of metal ion transport GO:0015672 monovalent inorganic cation transport GO:0015833 peptide transport GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0032496 response to lipopolysaccharide GO:0032868 response to insulin GO:0042493 response to drug GO:0042886 amide transport GO:0043266 regulation of potassium ion transport GO:0043268 positive regulation of potassium ion transport GO:0043270 positive regulation of ion transport GO:0043434 response to peptide hormone GO:0046676 negative regulation of insulin secretion GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046888 negative regulation of hormone secretion GO:0050708 regulation of protein secretion GO:0050709 negative regulation of protein secretion GO:0050796 regulation of insulin secretion GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051224 negative regulation of protein transport GO:0071804 cellular potassium ion transport GO:0071805 potassium ion transmembrane transport GO:0090087 regulation of peptide transport GO:0090276 regulation of peptide hormone secretion GO:0090278 negative regulation of peptide hormone secretion GO:0098656 anion transmembrane transport GO:1901652 response to peptide GO:1903531 negative regulation of secretion by cell GO:1904950 negative regulation of establishment of protein localization GO:1990267 response to transition metal nanoparticle |
Molecular Function |
GO:0000149 SNARE binding GO:0005216 ion channel activity GO:0005242 inward rectifier potassium channel activity GO:0005244 voltage-gated ion channel activity GO:0005249 voltage-gated potassium channel activity GO:0005261 cation channel activity GO:0005267 potassium channel activity GO:0008281 sulfonylurea receptor activity GO:0008509 anion transmembrane transporter activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015079 potassium ion transmembrane transporter activity GO:0015267 channel activity GO:0015272 ATP-activated inward rectifier potassium channel activity GO:0015276 ligand-gated ion channel activity GO:0015399 primary active transmembrane transporter activity GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016887 ATPase activity GO:0019905 syntaxin binding GO:0022803 passive transmembrane transporter activity GO:0022804 active transmembrane transporter activity GO:0022832 voltage-gated channel activity GO:0022834 ligand-gated channel activity GO:0022836 gated channel activity GO:0022838 substrate-specific channel activity GO:0022843 voltage-gated cation channel activity GO:0022853 active ion transmembrane transporter activity GO:0042623 ATPase activity, coupled GO:0042625 ATPase coupled ion transmembrane transporter activity GO:0042626 ATPase activity, coupled to transmembrane movement of substances GO:0043225 ATPase-coupled anion transmembrane transporter activity GO:0043492 ATPase activity, coupled to movement of substances GO:0044325 ion channel binding GO:0046873 metal ion transmembrane transporter activity |
Cellular Component |
GO:0008021 synaptic vesicle GO:0008076 voltage-gated potassium channel complex GO:0030133 transport vesicle GO:0030658 transport vesicle membrane GO:0030659 cytoplasmic vesicle membrane GO:0030672 synaptic vesicle membrane GO:0034702 ion channel complex GO:0034703 cation channel complex GO:0034705 potassium channel complex GO:0042383 sarcolemma GO:0070382 exocytic vesicle GO:0098793 presynapse GO:0099501 exocytic vesicle membrane GO:0099503 secretory vesicle GO:1902495 transmembrane transporter complex GO:1990351 transporter complex |
KEGG |
hsa02010 ABC transporters hsa04911 Insulin secretion |
Reactome |
R-HSA-5619084: ABC transporter disorders R-HSA-382556: ABC-family proteins mediated transport R-HSA-1296025: ATP sensitive Potassium channels R-HSA-5683177: Defective ABCC8 can cause hypoglycemias and hyperglycemias R-HSA-1643685: Disease R-HSA-5619115: Disorders of transmembrane transporters R-HSA-163685: Integration of energy metabolism R-HSA-1296065: Inwardly rectifying K+ channels R-HSA-1430728: Metabolism R-HSA-112316: Neuronal System R-HSA-1296071: Potassium Channels R-HSA-422356: Regulation of insulin secretion R-HSA-382551: Transmembrane transport of small molecules |
Summary | |
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Symbol | ABCC8 |
Name | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 |
Aliases | SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ABCC8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | ABCC8 |
Name | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 |
Aliases | SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ABCC8 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ABCC8 |
Name | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 |
Aliases | SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ABCC8 in various data sets.
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Points in the above scatter plot represent the mutation difference of ABCC8 in various data sets.
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Summary | |
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Symbol | ABCC8 |
Name | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 |
Aliases | SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ABCC8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ABCC8 |
Name | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 |
Aliases | SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ABCC8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ABCC8. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ABCC8 |
Name | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 |
Aliases | SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ABCC8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ABCC8 |
Name | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 |
Aliases | SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ABCC8 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ABCC8 |
Name | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 |
Aliases | SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ABCC8 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ABCC8 |
Name | ATP-binding cassette, sub-family C (CFTR/MRP), member 8 |
Aliases | SUR1; ABC36; HHF1; TNDM2; sulfonylurea receptor (hyperinsulinemia); SUR; HRINS; SUR1delta2; ATP-binding cass ...... |
Chromosomal Location | 11p15.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ABCC8 collected from DrugBank database. |
Details on drugs targeting ABCC8.
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