TISIDB

Summary
Symbol	ABCC9
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Aliases	CMD1O; sulfonylurea receptor 2; ABC37; ATFB12; CANTU; ATP-binding cassette transporter sub-family C member 9 ......
Chromosomal Location	12p12.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Membrane Multi-pass membrane protein
Domain	PF00664 ABC transporter transmembrane region PF00005 ABC transporter
Function	Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with KCNJ11. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation.

> Gene Ontology [ TOP ]
Biological Process	GO:0003013 circulatory system process GO:0003015 heart process GO:0006813 potassium ion transport GO:0006820 anion transport GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0009615 response to virus GO:0010107 potassium ion import GO:0015672 monovalent inorganic cation transport GO:0035637 multicellular organismal signaling GO:0044057 regulation of system process GO:0051607 defense response to virus GO:0060047 heart contraction GO:0061337 cardiac conduction GO:0071804 cellular potassium ion transport GO:0071805 potassium ion transmembrane transport GO:0098542 defense response to other organism GO:0098656 anion transmembrane transport GO:1903522 regulation of blood circulation GO:1903779 regulation of cardiac conduction
Molecular Function	GO:0005216 ion channel activity GO:0005261 cation channel activity GO:0005267 potassium channel activity GO:0008281 sulfonylurea receptor activity GO:0008509 anion transmembrane transporter activity GO:0015077 monovalent inorganic cation transmembrane transporter activity GO:0015079 potassium ion transmembrane transporter activity GO:0015267 channel activity GO:0015399 primary active transmembrane transporter activity GO:0015405 P-P-bond-hydrolysis-driven transmembrane transporter activity GO:0015459 potassium channel regulator activity GO:0016247 channel regulator activity GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances GO:0016887 ATPase activity GO:0022803 passive transmembrane transporter activity GO:0022804 active transmembrane transporter activity GO:0022838 substrate-specific channel activity GO:0022853 active ion transmembrane transporter activity GO:0042623 ATPase activity, coupled GO:0042625 ATPase coupled ion transmembrane transporter activity GO:0042626 ATPase activity, coupled to transmembrane movement of substances GO:0043225 ATPase-coupled anion transmembrane transporter activity GO:0043492 ATPase activity, coupled to movement of substances GO:0044325 ion channel binding GO:0046873 metal ion transmembrane transporter activity
Cellular Component	GO:0008076 voltage-gated potassium channel complex GO:0008282 ATP-sensitive potassium channel complex GO:0030016 myofibril GO:0030017 sarcomere GO:0034702 ion channel complex GO:0034703 cation channel complex GO:0034705 potassium channel complex GO:0042383 sarcolemma GO:0043292 contractile fiber GO:0044449 contractile fiber part GO:1902495 transmembrane transporter complex GO:1990351 transporter complex

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa02010 ABC transporters
Reactome	R-HSA-382556: ABC-family proteins mediated transport R-HSA-1296025: ATP sensitive Potassium channels R-HSA-5576891: Cardiac conduction R-HSA-1296065: Inwardly rectifying K+ channels R-HSA-5578775: Ion homeostasis R-HSA-397014: Muscle contraction R-HSA-112316: Neuronal System R-HSA-1296071: Potassium Channels R-HSA-382551: Transmembrane transport of small molecules

Summary
Symbol	ABCC9
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Aliases	CMD1O; sulfonylurea receptor 2; ABC37; ATFB12; CANTU; ATP-binding cassette transporter sub-family C member 9 ......
Chromosomal Location	12p12.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between ABCC9 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	ABCC9
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Aliases	CMD1O; sulfonylurea receptor 2; ABC37; ATFB12; CANTU; ATP-binding cassette transporter sub-family C member 9 ......
Chromosomal Location	12p12.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of ABCC9 in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	Second most enriched score: 0.75	Sensitive to T cell-mediated killing
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	ABCC9
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Aliases	CMD1O; sulfonylurea receptor 2; ABC37; ATFB12; CANTU; ATP-binding cassette transporter sub-family C member 9 ......
Chromosomal Location	12p12.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of ABCC9 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	-0.399	0.207
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.794	0.343
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	-0.108	0.863
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.633	0.154
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-0.773	0.698
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	-0.462	0.846
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	0.133	0.787
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	0.304	0.788
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-0.117	0.929
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	-0.034	0.972
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	0.73	0.551
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.398	0.025

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of ABCC9 in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	18.5	6.8	11.7	0.128
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	18.5	8.5	10	0.275
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	0	23.5	-23.5	0.0322
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	0	0	0	1
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	0	36.4	-36.4	0.0311
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	12.5	-12.5	0.52
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	11.1	-11.1	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	14.3	-14.3	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	10.5	3.7	6.8	0.393
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	13.6	7.7	5.9	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	6.2	0	6.2	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	15.4	-15.4	0.482
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	16.7	-16.7	1

Summary
Symbol	ABCC9
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Aliases	CMD1O; sulfonylurea receptor 2; ABC37; ATFB12; CANTU; ATP-binding cassette transporter sub-family C member 9 ......
Chromosomal Location	12p12.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ABCC9. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	ABCC9
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Aliases	CMD1O; sulfonylurea receptor 2; ABC37; ATFB12; CANTU; ATP-binding cassette transporter sub-family C member 9 ......
Chromosomal Location	12p12.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ABCC9. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ABCC9. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	ABCC9
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Aliases	CMD1O; sulfonylurea receptor 2; ABC37; ATFB12; CANTU; ATP-binding cassette transporter sub-family C member 9 ......
Chromosomal Location	12p12.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ABCC9. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	ABCC9
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Aliases	CMD1O; sulfonylurea receptor 2; ABC37; ATFB12; CANTU; ATP-binding cassette transporter sub-family C member 9 ......
Chromosomal Location	12p12.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of ABCC9 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	ABCC9
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Aliases	CMD1O; sulfonylurea receptor 2; ABC37; ATFB12; CANTU; ATP-binding cassette transporter sub-family C member 9 ......
Chromosomal Location	12p12.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between ABCC9 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	ABCC9
Name	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Aliases	CMD1O; sulfonylurea receptor 2; ABC37; ATFB12; CANTU; ATP-binding cassette transporter sub-family C member 9 ......
Chromosomal Location	12p12.1
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting ABCC9 collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting ABCC9.

ID	Name	Drug Type	Targets	#Targets
DB00171	ATP	Small Molecule	ABCA1, ABCB1, ABCB11, ABCC1, ABCC2, ABCC4, ABCC6, ABCC8, ABCC9, AB ......	42
DB01016	Glyburide	Small Molecule	ABCA1, ABCB11, ABCC8, ABCC9, CFTR, CPT1A, KCNJ11, KCNJ11, KCNJ5, K ......	10
DB09220	Nicorandil	Small Molecule	ABCC9	1

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