Summary | |
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Symbol | ABL1 |
Name | ABL proto-oncogene 1, non-receptor tyrosine kinase |
Aliases | JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ...... |
Chromosomal Location | 9q34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton. Nucleus. Mitochondrion Note=Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress (By similarity). ; SUBCELLULAR LOCATION: Isoform IB: Nucleus membrane; Lipid-anchor. Note=The myristoylated c-ABL protein is reported to be nuclear. |
Domain |
PF08919 F-actin binding PF07714 Protein tyrosine kinase PF00017 SH2 domain PF00018 SH3 domain |
Function |
Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). |
Biological Process |
GO:0000226 microtubule cytoskeleton organization GO:0000302 response to reactive oxygen species GO:0001558 regulation of cell growth GO:0001736 establishment of planar polarity GO:0001738 morphogenesis of a polarized epithelium GO:0001776 leukocyte homeostasis GO:0001782 B cell homeostasis GO:0001819 positive regulation of cytokine production GO:0001922 B-1 B cell homeostasis GO:0001933 negative regulation of protein phosphorylation GO:0002237 response to molecule of bacterial origin GO:0002260 lymphocyte homeostasis GO:0002263 cell activation involved in immune response GO:0002285 lymphocyte activation involved in immune response GO:0002312 B cell activation involved in immune response GO:0002322 B cell proliferation involved in immune response GO:0002327 immature B cell differentiation GO:0002332 transitional stage B cell differentiation GO:0002333 transitional one stage B cell differentiation GO:0002366 leukocyte activation involved in immune response GO:0002429 immune response-activating cell surface receptor signaling pathway GO:0002431 Fc receptor mediated stimulatory signaling pathway GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis GO:0002521 leukocyte differentiation GO:0002757 immune response-activating signal transduction GO:0002764 immune response-regulating signaling pathway GO:0002768 immune response-regulating cell surface receptor signaling pathway GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0006298 mismatch repair GO:0006469 negative regulation of protein kinase activity GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006909 phagocytosis GO:0006914 autophagy GO:0006975 DNA damage induced protein phosphorylation GO:0006979 response to oxidative stress GO:0007015 actin filament organization GO:0007050 cell cycle arrest GO:0007067 mitotic nuclear division GO:0007159 leukocyte cell-cell adhesion GO:0007162 negative regulation of cell adhesion GO:0007164 establishment of tissue polarity GO:0007173 epidermal growth factor receptor signaling pathway GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007249 I-kappaB kinase/NF-kappaB signaling GO:0007346 regulation of mitotic cell cycle GO:0007409 axonogenesis GO:0007568 aging GO:0007569 cell aging GO:0007611 learning or memory GO:0007612 learning GO:0008015 blood circulation GO:0008154 actin polymerization or depolymerization GO:0008306 associative learning GO:0008361 regulation of cell size GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage GO:0009306 protein secretion GO:0010001 glial cell differentiation GO:0010035 response to inorganic substance GO:0010421 hydrogen peroxide-mediated programmed cell death GO:0010506 regulation of autophagy GO:0010517 regulation of phospholipase activity GO:0010519 negative regulation of phospholipase activity GO:0010522 regulation of calcium ion transport into cytosol GO:0010524 positive regulation of calcium ion transport into cytosol GO:0010720 positive regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010959 regulation of metal ion transport GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0016049 cell growth GO:0016055 Wnt signaling pathway GO:0016358 dendrite development GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019229 regulation of vasoconstriction GO:0021549 cerebellum development GO:0021575 hindbrain morphogenesis GO:0021587 cerebellum morphogenesis GO:0022037 metencephalon development GO:0022407 regulation of cell-cell adhesion GO:0022408 negative regulation of cell-cell adhesion GO:0022604 regulation of cell morphogenesis GO:0030031 cell projection assembly GO:0030035 microspike assembly GO:0030041 actin filament polymerization GO:0030098 lymphocyte differentiation GO:0030100 regulation of endocytosis GO:0030111 regulation of Wnt signaling pathway GO:0030177 positive regulation of Wnt signaling pathway GO:0030183 B cell differentiation GO:0030198 extracellular matrix organization GO:0030217 T cell differentiation GO:0030509 BMP signaling pathway GO:0030510 regulation of BMP signaling pathway GO:0030514 negative regulation of BMP signaling pathway GO:0030516 regulation of axon extension GO:0030902 hindbrain development GO:0031109 microtubule polymerization or depolymerization GO:0031110 regulation of microtubule polymerization or depolymerization GO:0031113 regulation of microtubule polymerization GO:0031346 positive regulation of cell projection organization GO:0031396 regulation of protein ubiquitination GO:0031397 negative regulation of protein ubiquitination GO:0031532 actin cytoskeleton reorganization GO:0031589 cell-substrate adhesion GO:0032092 positive regulation of protein binding GO:0032147 activation of protein kinase activity GO:0032271 regulation of protein polymerization GO:0032496 response to lipopolysaccharide GO:0032535 regulation of cellular component size GO:0032609 interferon-gamma production GO:0032623 interleukin-2 production GO:0032649 regulation of interferon-gamma production GO:0032663 regulation of interleukin-2 production GO:0032729 positive regulation of interferon-gamma production GO:0032743 positive regulation of interleukin-2 production GO:0032844 regulation of homeostatic process GO:0032845 negative regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0032886 regulation of microtubule-based process GO:0032943 mononuclear cell proliferation GO:0032956 regulation of actin cytoskeleton organization GO:0032970 regulation of actin filament-based process GO:0033673 negative regulation of kinase activity GO:0033674 positive regulation of kinase activity GO:0033687 osteoblast proliferation GO:0033688 regulation of osteoblast proliferation GO:0033690 positive regulation of osteoblast proliferation GO:0034446 substrate adhesion-dependent cell spreading GO:0034599 cellular response to oxidative stress GO:0034614 cellular response to reactive oxygen species GO:0034762 regulation of transmembrane transport GO:0034764 positive regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0034767 positive regulation of ion transmembrane transport GO:0034976 response to endoplasmic reticulum stress GO:0035150 regulation of tube size GO:0035567 non-canonical Wnt signaling pathway GO:0035791 platelet-derived growth factor receptor-beta signaling pathway GO:0036473 cell death in response to oxidative stress GO:0036474 cell death in response to hydrogen peroxide GO:0038083 peptidyl-tyrosine autophosphorylation GO:0038093 Fc receptor signaling pathway GO:0038094 Fc-gamma receptor signaling pathway GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis GO:0038127 ERBB signaling pathway GO:0042063 gliogenesis GO:0042098 T cell proliferation GO:0042100 B cell proliferation GO:0042110 T cell activation GO:0042113 B cell activation GO:0042310 vasoconstriction GO:0042326 negative regulation of phosphorylation GO:0042391 regulation of membrane potential GO:0042493 response to drug GO:0042542 response to hydrogen peroxide GO:0042692 muscle cell differentiation GO:0042770 signal transduction in response to DNA damage GO:0043062 extracellular structure organization GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043254 regulation of protein complex assembly GO:0043270 positive regulation of ion transport GO:0043393 regulation of protein binding GO:0043409 negative regulation of MAPK cascade GO:0043410 positive regulation of MAPK cascade GO:0043523 regulation of neuron apoptotic process GO:0043525 positive regulation of neuron apoptotic process GO:0044057 regulation of system process GO:0044708 single-organism behavior GO:0045666 positive regulation of neuron differentiation GO:0045786 negative regulation of cell cycle GO:0045787 positive regulation of cell cycle GO:0045860 positive regulation of protein kinase activity GO:0045907 positive regulation of vasoconstriction GO:0045930 negative regulation of mitotic cell cycle GO:0045931 positive regulation of mitotic cell cycle GO:0046631 alpha-beta T cell activation GO:0046632 alpha-beta T cell differentiation GO:0046651 lymphocyte proliferation GO:0046777 protein autophosphorylation GO:0046785 microtubule polymerization GO:0048008 platelet-derived growth factor receptor signaling pathway GO:0048144 fibroblast proliferation GO:0048145 regulation of fibroblast proliferation GO:0048146 positive regulation of fibroblast proliferation GO:0048536 spleen development GO:0048538 thymus development GO:0048588 developmental cell growth GO:0048638 regulation of developmental growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048668 collateral sprouting GO:0048675 axon extension GO:0048708 astrocyte differentiation GO:0048732 gland development GO:0048872 homeostasis of number of cells GO:0050663 cytokine secretion GO:0050707 regulation of cytokine secretion GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050715 positive regulation of cytokine secretion GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050769 positive regulation of neurogenesis GO:0050770 regulation of axonogenesis GO:0050773 regulation of dendrite development GO:0050798 activated T cell proliferation GO:0050851 antigen receptor-mediated signaling pathway GO:0050853 B cell receptor signaling pathway GO:0050880 regulation of blood vessel size GO:0050885 neuromuscular process controlling balance GO:0050890 cognition GO:0050905 neuromuscular process GO:0051047 positive regulation of secretion GO:0051098 regulation of binding GO:0051099 positive regulation of binding GO:0051147 regulation of muscle cell differentiation GO:0051149 positive regulation of muscle cell differentiation GO:0051208 sequestering of calcium ion GO:0051209 release of sequestered calcium ion into cytosol GO:0051222 positive regulation of protein transport GO:0051235 maintenance of location GO:0051238 sequestering of metal ion GO:0051258 protein polymerization GO:0051279 regulation of release of sequestered calcium ion into cytosol GO:0051281 positive regulation of release of sequestered calcium ion into cytosol GO:0051282 regulation of sequestering of calcium ion GO:0051283 negative regulation of sequestering of calcium ion GO:0051341 regulation of oxidoreductase activity GO:0051346 negative regulation of hydrolase activity GO:0051348 negative regulation of transferase activity GO:0051353 positive regulation of oxidoreductase activity GO:0051402 neuron apoptotic process GO:0051438 regulation of ubiquitin-protein transferase activity GO:0051444 negative regulation of ubiquitin-protein transferase activity GO:0051480 regulation of cytosolic calcium ion concentration GO:0051493 regulation of cytoskeleton organization GO:0051881 regulation of mitochondrial membrane potential GO:0051882 mitochondrial depolarization GO:0051899 membrane depolarization GO:0051924 regulation of calcium ion transport GO:0051928 positive regulation of calcium ion transport GO:0051962 positive regulation of nervous system development GO:0055074 calcium ion homeostasis GO:0060020 Bergmann glial cell differentiation GO:0060071 Wnt signaling pathway, planar cell polarity pathway GO:0060191 regulation of lipase activity GO:0060192 negative regulation of lipase activity GO:0060401 cytosolic calcium ion transport GO:0060402 calcium ion transport into cytosol GO:0060560 developmental growth involved in morphogenesis GO:0060627 regulation of vesicle-mediated transport GO:0061387 regulation of extent of cell growth GO:0061564 axon development GO:0070301 cellular response to hydrogen peroxide GO:0070371 ERK1 and ERK2 cascade GO:0070372 regulation of ERK1 and ERK2 cascade GO:0070373 negative regulation of ERK1 and ERK2 cascade GO:0070374 positive regulation of ERK1 and ERK2 cascade GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070507 regulation of microtubule cytoskeleton organization GO:0070509 calcium ion import GO:0070588 calcium ion transmembrane transport GO:0070661 leukocyte proliferation GO:0070838 divalent metal ion transport GO:0070970 interleukin-2 secretion GO:0070997 neuron death GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0071593 lymphocyte aggregation GO:0071772 response to BMP GO:0071773 cellular response to BMP stimulus GO:0071867 response to monoamine GO:0071868 cellular response to monoamine stimulus GO:0071869 response to catecholamine GO:0071870 cellular response to catecholamine stimulus GO:0071871 response to epinephrine GO:0071900 regulation of protein serine/threonine kinase activity GO:0071901 negative regulation of protein serine/threonine kinase activity GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0072577 endothelial cell apoptotic process GO:0072643 interferon-gamma secretion GO:0090066 regulation of anatomical structure size GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway GO:0090135 actin filament branching GO:0090175 regulation of establishment of planar polarity GO:0090279 regulation of calcium ion import GO:0090280 positive regulation of calcium ion import GO:0090287 regulation of cellular response to growth factor stimulus GO:0090288 negative regulation of cellular response to growth factor stimulus GO:0090342 regulation of cell aging GO:0090344 negative regulation of cell aging GO:0090398 cellular senescence GO:0097193 intrinsic apoptotic signaling pathway GO:0097468 programmed cell death in response to reactive oxygen species GO:0097553 calcium ion transmembrane import into cytosol GO:0198738 cell-cell signaling by wnt GO:1900006 positive regulation of dendrite development GO:1900040 regulation of interleukin-2 secretion GO:1900042 positive regulation of interleukin-2 secretion GO:1900274 regulation of phospholipase C activity GO:1900275 negative regulation of phospholipase C activity GO:1900407 regulation of cellular response to oxidative stress GO:1900409 positive regulation of cellular response to oxidative stress GO:1901031 regulation of response to reactive oxygen species GO:1901033 positive regulation of response to reactive oxygen species GO:1901214 regulation of neuron death GO:1901216 positive regulation of neuron death GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death GO:1902532 negative regulation of intracellular signal transduction GO:1902656 calcium ion import into cytosol GO:1902713 regulation of interferon-gamma secretion GO:1902715 positive regulation of interferon-gamma secretion GO:1902882 regulation of response to oxidative stress GO:1902884 positive regulation of response to oxidative stress GO:1903053 regulation of extracellular matrix organization GO:1903055 positive regulation of extracellular matrix organization GO:1903169 regulation of calcium ion transmembrane transport GO:1903201 regulation of oxidative stress-induced cell death GO:1903205 regulation of hydrogen peroxide-induced cell death GO:1903209 positive regulation of oxidative stress-induced cell death GO:1903210 glomerular visceral epithelial cell apoptotic process GO:1903320 regulation of protein modification by small protein conjugation or removal GO:1903321 negative regulation of protein modification by small protein conjugation or removal GO:1903350 response to dopamine GO:1903351 cellular response to dopamine GO:1903522 regulation of blood circulation GO:1903524 positive regulation of blood circulation GO:1903532 positive regulation of secretion by cell GO:1904019 epithelial cell apoptotic process GO:1904035 regulation of epithelial cell apoptotic process GO:1904036 negative regulation of epithelial cell apoptotic process GO:1904062 regulation of cation transmembrane transport GO:1904064 positive regulation of cation transmembrane transport GO:1904427 positive regulation of calcium ion transmembrane transport GO:1904526 regulation of microtubule binding GO:1904528 positive regulation of microtubule binding GO:1904529 regulation of actin filament binding GO:1904531 positive regulation of actin filament binding GO:1904616 regulation of actin binding GO:1904618 positive regulation of actin binding GO:1904951 positive regulation of establishment of protein localization GO:1905206 positive regulation of hydrogen peroxide-induced cell death GO:1905330 regulation of morphogenesis of an epithelium GO:1990051 activation of protein kinase C activity GO:1990138 neuron projection extension GO:2000021 regulation of ion homeostasis GO:2000027 regulation of organ morphogenesis GO:2000050 regulation of non-canonical Wnt signaling pathway GO:2000052 positive regulation of non-canonical Wnt signaling pathway GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway GO:2000249 regulation of actin cytoskeleton reorganization GO:2000351 regulation of endothelial cell apoptotic process GO:2000352 negative regulation of endothelial cell apoptotic process GO:2000772 regulation of cellular senescence GO:2000773 negative regulation of cellular senescence GO:2001020 regulation of response to DNA damage stimulus |
Molecular Function |
GO:0000149 SNARE binding GO:0000287 magnesium ion binding GO:0003779 actin binding GO:0003785 actin monomer binding GO:0004515 nicotinate-nucleotide adenylyltransferase activity GO:0004713 protein tyrosine kinase activity GO:0004715 non-membrane spanning protein tyrosine kinase activity GO:0005080 protein kinase C binding GO:0008022 protein C-terminus binding GO:0016779 nucleotidyltransferase activity GO:0017124 SH3 domain binding GO:0019905 syntaxin binding GO:0030145 manganese ion binding GO:0051015 actin filament binding GO:0051019 mitogen-activated protein kinase binding GO:0070064 proline-rich region binding GO:0070097 delta-catenin binding GO:0070566 adenylyltransferase activity |
Cellular Component |
GO:0001726 ruffle GO:0005635 nuclear envelope GO:0009898 cytoplasmic side of plasma membrane GO:0015629 actin cytoskeleton GO:0019897 extrinsic component of plasma membrane GO:0019898 extrinsic component of membrane GO:0030426 growth cone GO:0030427 site of polarized growth GO:0031234 extrinsic component of cytoplasmic side of plasma membrane GO:0031252 cell leading edge GO:0031965 nuclear membrane GO:0043025 neuronal cell body GO:0044297 cell body GO:0098552 side of membrane GO:0098562 cytoplasmic side of membrane |
KEGG |
hsa04012 ErbB signaling pathway hsa04014 Ras signaling pathway hsa04110 Cell cycle hsa04360 Axon guidance hsa04722 Neurotrophin signaling pathway |
Reactome |
R-HSA-422475: Axon guidance R-HSA-375170: CDO in myogenesis R-HSA-5693606: DNA Double Strand Break Response R-HSA-5693532: DNA Double-Strand Break Repair R-HSA-73894: DNA Repair R-HSA-1266738: Developmental Biology R-HSA-983231: Factors involved in megakaryocyte development and platelet production R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis R-HSA-5693567: HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) R-HSA-5685938: HDR through Single Strand Annealing (SSA) R-HSA-109582: Hemostasis R-HSA-5693538: Homology Directed Repair R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-525793: Myogenesis R-HSA-195258: RHO GTPase Effectors R-HSA-5663213: RHO GTPases Activate WASPs and WAVEs R-HSA-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks R-HSA-2029482: Regulation of actin dynamics for phagocytic cup formation R-HSA-428890: Role of Abl in Robo-Slit signaling R-HSA-162582: Signal Transduction R-HSA-194315: Signaling by Rho GTPases R-HSA-376176: Signaling by Robo receptor |
Summary | |
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Symbol | ABL1 |
Name | ABL proto-oncogene 1, non-receptor tyrosine kinase |
Aliases | JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ...... |
Chromosomal Location | 9q34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ABL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ABL1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ABL1 |
Name | ABL proto-oncogene 1, non-receptor tyrosine kinase |
Aliases | JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ...... |
Chromosomal Location | 9q34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ABL1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ABL1 |
Name | ABL proto-oncogene 1, non-receptor tyrosine kinase |
Aliases | JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ...... |
Chromosomal Location | 9q34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ABL1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ABL1 in various data sets.
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Summary | |
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Symbol | ABL1 |
Name | ABL proto-oncogene 1, non-receptor tyrosine kinase |
Aliases | JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ...... |
Chromosomal Location | 9q34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ABL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ABL1 |
Name | ABL proto-oncogene 1, non-receptor tyrosine kinase |
Aliases | JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ...... |
Chromosomal Location | 9q34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ABL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ABL1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ABL1 |
Name | ABL proto-oncogene 1, non-receptor tyrosine kinase |
Aliases | JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ...... |
Chromosomal Location | 9q34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ABL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ABL1 |
Name | ABL proto-oncogene 1, non-receptor tyrosine kinase |
Aliases | JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ...... |
Chromosomal Location | 9q34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ABL1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ABL1 |
Name | ABL proto-oncogene 1, non-receptor tyrosine kinase |
Aliases | JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ...... |
Chromosomal Location | 9q34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ABL1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ABL1 |
Name | ABL proto-oncogene 1, non-receptor tyrosine kinase |
Aliases | JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ...... |
Chromosomal Location | 9q34.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ABL1 collected from DrugBank database. |
Details on drugs targeting ABL1.
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