Browse ABL1

Summary
SymbolABL1
NameABL proto-oncogene 1, non-receptor tyrosine kinase
Aliases JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ......
Chromosomal Location9q34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, cytoskeleton. Nucleus. Mitochondrion Note=Shuttles between the nucleus and cytoplasm depending on environmental signals. Sequestered into the cytoplasm through interaction with 14-3-3 proteins. Localizes to mitochondria in response to oxidative stress (By similarity). ; SUBCELLULAR LOCATION: Isoform IB: Nucleus membrane; Lipid-anchor. Note=The myristoylated c-ABL protein is reported to be nuclear.
Domain PF08919 F-actin binding
PF07714 Protein tyrosine kinase
PF00017 SH2 domain
PF00018 SH3 domain
Function

Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity).

> Gene Ontology
 
Biological Process GO:0000226 microtubule cytoskeleton organization
GO:0000302 response to reactive oxygen species
GO:0001558 regulation of cell growth
GO:0001736 establishment of planar polarity
GO:0001738 morphogenesis of a polarized epithelium
GO:0001776 leukocyte homeostasis
GO:0001782 B cell homeostasis
GO:0001819 positive regulation of cytokine production
GO:0001922 B-1 B cell homeostasis
GO:0001933 negative regulation of protein phosphorylation
GO:0002237 response to molecule of bacterial origin
GO:0002260 lymphocyte homeostasis
GO:0002263 cell activation involved in immune response
GO:0002285 lymphocyte activation involved in immune response
GO:0002312 B cell activation involved in immune response
GO:0002322 B cell proliferation involved in immune response
GO:0002327 immature B cell differentiation
GO:0002332 transitional stage B cell differentiation
GO:0002333 transitional one stage B cell differentiation
GO:0002366 leukocyte activation involved in immune response
GO:0002429 immune response-activating cell surface receptor signaling pathway
GO:0002431 Fc receptor mediated stimulatory signaling pathway
GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
GO:0002521 leukocyte differentiation
GO:0002757 immune response-activating signal transduction
GO:0002764 immune response-regulating signaling pathway
GO:0002768 immune response-regulating cell surface receptor signaling pathway
GO:0003013 circulatory system process
GO:0003018 vascular process in circulatory system
GO:0006298 mismatch repair
GO:0006469 negative regulation of protein kinase activity
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006909 phagocytosis
GO:0006914 autophagy
GO:0006975 DNA damage induced protein phosphorylation
GO:0006979 response to oxidative stress
GO:0007015 actin filament organization
GO:0007050 cell cycle arrest
GO:0007067 mitotic nuclear division
GO:0007159 leukocyte cell-cell adhesion
GO:0007162 negative regulation of cell adhesion
GO:0007164 establishment of tissue polarity
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007346 regulation of mitotic cell cycle
GO:0007409 axonogenesis
GO:0007568 aging
GO:0007569 cell aging
GO:0007611 learning or memory
GO:0007612 learning
GO:0008015 blood circulation
GO:0008154 actin polymerization or depolymerization
GO:0008306 associative learning
GO:0008361 regulation of cell size
GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage
GO:0009306 protein secretion
GO:0010001 glial cell differentiation
GO:0010035 response to inorganic substance
GO:0010421 hydrogen peroxide-mediated programmed cell death
GO:0010506 regulation of autophagy
GO:0010517 regulation of phospholipase activity
GO:0010519 negative regulation of phospholipase activity
GO:0010522 regulation of calcium ion transport into cytosol
GO:0010524 positive regulation of calcium ion transport into cytosol
GO:0010720 positive regulation of cell development
GO:0010769 regulation of cell morphogenesis involved in differentiation
GO:0010959 regulation of metal ion transport
GO:0010975 regulation of neuron projection development
GO:0010976 positive regulation of neuron projection development
GO:0016049 cell growth
GO:0016055 Wnt signaling pathway
GO:0016358 dendrite development
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0018212 peptidyl-tyrosine modification
GO:0019229 regulation of vasoconstriction
GO:0021549 cerebellum development
GO:0021575 hindbrain morphogenesis
GO:0021587 cerebellum morphogenesis
GO:0022037 metencephalon development
GO:0022407 regulation of cell-cell adhesion
GO:0022408 negative regulation of cell-cell adhesion
GO:0022604 regulation of cell morphogenesis
GO:0030031 cell projection assembly
GO:0030035 microspike assembly
GO:0030041 actin filament polymerization
GO:0030098 lymphocyte differentiation
GO:0030100 regulation of endocytosis
GO:0030111 regulation of Wnt signaling pathway
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030183 B cell differentiation
GO:0030198 extracellular matrix organization
GO:0030217 T cell differentiation
GO:0030509 BMP signaling pathway
GO:0030510 regulation of BMP signaling pathway
GO:0030514 negative regulation of BMP signaling pathway
GO:0030516 regulation of axon extension
GO:0030902 hindbrain development
GO:0031109 microtubule polymerization or depolymerization
GO:0031110 regulation of microtubule polymerization or depolymerization
GO:0031113 regulation of microtubule polymerization
GO:0031346 positive regulation of cell projection organization
GO:0031396 regulation of protein ubiquitination
GO:0031397 negative regulation of protein ubiquitination
GO:0031532 actin cytoskeleton reorganization
GO:0031589 cell-substrate adhesion
GO:0032092 positive regulation of protein binding
GO:0032147 activation of protein kinase activity
GO:0032271 regulation of protein polymerization
GO:0032496 response to lipopolysaccharide
GO:0032535 regulation of cellular component size
GO:0032609 interferon-gamma production
GO:0032623 interleukin-2 production
GO:0032649 regulation of interferon-gamma production
GO:0032663 regulation of interleukin-2 production
GO:0032729 positive regulation of interferon-gamma production
GO:0032743 positive regulation of interleukin-2 production
GO:0032844 regulation of homeostatic process
GO:0032845 negative regulation of homeostatic process
GO:0032846 positive regulation of homeostatic process
GO:0032886 regulation of microtubule-based process
GO:0032943 mononuclear cell proliferation
GO:0032956 regulation of actin cytoskeleton organization
GO:0032970 regulation of actin filament-based process
GO:0033673 negative regulation of kinase activity
GO:0033674 positive regulation of kinase activity
GO:0033687 osteoblast proliferation
GO:0033688 regulation of osteoblast proliferation
GO:0033690 positive regulation of osteoblast proliferation
GO:0034446 substrate adhesion-dependent cell spreading
GO:0034599 cellular response to oxidative stress
GO:0034614 cellular response to reactive oxygen species
GO:0034762 regulation of transmembrane transport
GO:0034764 positive regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034767 positive regulation of ion transmembrane transport
GO:0034976 response to endoplasmic reticulum stress
GO:0035150 regulation of tube size
GO:0035567 non-canonical Wnt signaling pathway
GO:0035791 platelet-derived growth factor receptor-beta signaling pathway
GO:0036473 cell death in response to oxidative stress
GO:0036474 cell death in response to hydrogen peroxide
GO:0038083 peptidyl-tyrosine autophosphorylation
GO:0038093 Fc receptor signaling pathway
GO:0038094 Fc-gamma receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0038127 ERBB signaling pathway
GO:0042063 gliogenesis
GO:0042098 T cell proliferation
GO:0042100 B cell proliferation
GO:0042110 T cell activation
GO:0042113 B cell activation
GO:0042310 vasoconstriction
GO:0042326 negative regulation of phosphorylation
GO:0042391 regulation of membrane potential
GO:0042493 response to drug
GO:0042542 response to hydrogen peroxide
GO:0042692 muscle cell differentiation
GO:0042770 signal transduction in response to DNA damage
GO:0043062 extracellular structure organization
GO:0043122 regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043254 regulation of protein complex assembly
GO:0043270 positive regulation of ion transport
GO:0043393 regulation of protein binding
GO:0043409 negative regulation of MAPK cascade
GO:0043410 positive regulation of MAPK cascade
GO:0043523 regulation of neuron apoptotic process
GO:0043525 positive regulation of neuron apoptotic process
GO:0044057 regulation of system process
GO:0044708 single-organism behavior
GO:0045666 positive regulation of neuron differentiation
GO:0045786 negative regulation of cell cycle
GO:0045787 positive regulation of cell cycle
GO:0045860 positive regulation of protein kinase activity
GO:0045907 positive regulation of vasoconstriction
GO:0045930 negative regulation of mitotic cell cycle
GO:0045931 positive regulation of mitotic cell cycle
GO:0046631 alpha-beta T cell activation
GO:0046632 alpha-beta T cell differentiation
GO:0046651 lymphocyte proliferation
GO:0046777 protein autophosphorylation
GO:0046785 microtubule polymerization
GO:0048008 platelet-derived growth factor receptor signaling pathway
GO:0048144 fibroblast proliferation
GO:0048145 regulation of fibroblast proliferation
GO:0048146 positive regulation of fibroblast proliferation
GO:0048536 spleen development
GO:0048538 thymus development
GO:0048588 developmental cell growth
GO:0048638 regulation of developmental growth
GO:0048667 cell morphogenesis involved in neuron differentiation
GO:0048668 collateral sprouting
GO:0048675 axon extension
GO:0048708 astrocyte differentiation
GO:0048732 gland development
GO:0048872 homeostasis of number of cells
GO:0050663 cytokine secretion
GO:0050707 regulation of cytokine secretion
GO:0050708 regulation of protein secretion
GO:0050714 positive regulation of protein secretion
GO:0050715 positive regulation of cytokine secretion
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0050769 positive regulation of neurogenesis
GO:0050770 regulation of axonogenesis
GO:0050773 regulation of dendrite development
GO:0050798 activated T cell proliferation
GO:0050851 antigen receptor-mediated signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0050880 regulation of blood vessel size
GO:0050885 neuromuscular process controlling balance
GO:0050890 cognition
GO:0050905 neuromuscular process
GO:0051047 positive regulation of secretion
GO:0051098 regulation of binding
GO:0051099 positive regulation of binding
GO:0051147 regulation of muscle cell differentiation
GO:0051149 positive regulation of muscle cell differentiation
GO:0051208 sequestering of calcium ion
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051222 positive regulation of protein transport
GO:0051235 maintenance of location
GO:0051238 sequestering of metal ion
GO:0051258 protein polymerization
GO:0051279 regulation of release of sequestered calcium ion into cytosol
GO:0051281 positive regulation of release of sequestered calcium ion into cytosol
GO:0051282 regulation of sequestering of calcium ion
GO:0051283 negative regulation of sequestering of calcium ion
GO:0051341 regulation of oxidoreductase activity
GO:0051346 negative regulation of hydrolase activity
GO:0051348 negative regulation of transferase activity
GO:0051353 positive regulation of oxidoreductase activity
GO:0051402 neuron apoptotic process
GO:0051438 regulation of ubiquitin-protein transferase activity
GO:0051444 negative regulation of ubiquitin-protein transferase activity
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0051493 regulation of cytoskeleton organization
GO:0051881 regulation of mitochondrial membrane potential
GO:0051882 mitochondrial depolarization
GO:0051899 membrane depolarization
GO:0051924 regulation of calcium ion transport
GO:0051928 positive regulation of calcium ion transport
GO:0051962 positive regulation of nervous system development
GO:0055074 calcium ion homeostasis
GO:0060020 Bergmann glial cell differentiation
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060191 regulation of lipase activity
GO:0060192 negative regulation of lipase activity
GO:0060401 cytosolic calcium ion transport
GO:0060402 calcium ion transport into cytosol
GO:0060560 developmental growth involved in morphogenesis
GO:0060627 regulation of vesicle-mediated transport
GO:0061387 regulation of extent of cell growth
GO:0061564 axon development
GO:0070301 cellular response to hydrogen peroxide
GO:0070371 ERK1 and ERK2 cascade
GO:0070372 regulation of ERK1 and ERK2 cascade
GO:0070373 negative regulation of ERK1 and ERK2 cascade
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070507 regulation of microtubule cytoskeleton organization
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0070661 leukocyte proliferation
GO:0070838 divalent metal ion transport
GO:0070970 interleukin-2 secretion
GO:0070997 neuron death
GO:0071216 cellular response to biotic stimulus
GO:0071219 cellular response to molecule of bacterial origin
GO:0071222 cellular response to lipopolysaccharide
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0071559 response to transforming growth factor beta
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0071593 lymphocyte aggregation
GO:0071772 response to BMP
GO:0071773 cellular response to BMP stimulus
GO:0071867 response to monoamine
GO:0071868 cellular response to monoamine stimulus
GO:0071869 response to catecholamine
GO:0071870 cellular response to catecholamine stimulus
GO:0071871 response to epinephrine
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071901 negative regulation of protein serine/threonine kinase activity
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0072577 endothelial cell apoptotic process
GO:0072643 interferon-gamma secretion
GO:0090066 regulation of anatomical structure size
GO:0090092 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090101 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0090135 actin filament branching
GO:0090175 regulation of establishment of planar polarity
GO:0090279 regulation of calcium ion import
GO:0090280 positive regulation of calcium ion import
GO:0090287 regulation of cellular response to growth factor stimulus
GO:0090288 negative regulation of cellular response to growth factor stimulus
GO:0090342 regulation of cell aging
GO:0090344 negative regulation of cell aging
GO:0090398 cellular senescence
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097468 programmed cell death in response to reactive oxygen species
GO:0097553 calcium ion transmembrane import into cytosol
GO:0198738 cell-cell signaling by wnt
GO:1900006 positive regulation of dendrite development
GO:1900040 regulation of interleukin-2 secretion
GO:1900042 positive regulation of interleukin-2 secretion
GO:1900274 regulation of phospholipase C activity
GO:1900275 negative regulation of phospholipase C activity
GO:1900407 regulation of cellular response to oxidative stress
GO:1900409 positive regulation of cellular response to oxidative stress
GO:1901031 regulation of response to reactive oxygen species
GO:1901033 positive regulation of response to reactive oxygen species
GO:1901214 regulation of neuron death
GO:1901216 positive regulation of neuron death
GO:1901298 regulation of hydrogen peroxide-mediated programmed cell death
GO:1901300 positive regulation of hydrogen peroxide-mediated programmed cell death
GO:1902532 negative regulation of intracellular signal transduction
GO:1902656 calcium ion import into cytosol
GO:1902713 regulation of interferon-gamma secretion
GO:1902715 positive regulation of interferon-gamma secretion
GO:1902882 regulation of response to oxidative stress
GO:1902884 positive regulation of response to oxidative stress
GO:1903053 regulation of extracellular matrix organization
GO:1903055 positive regulation of extracellular matrix organization
GO:1903169 regulation of calcium ion transmembrane transport
GO:1903201 regulation of oxidative stress-induced cell death
GO:1903205 regulation of hydrogen peroxide-induced cell death
GO:1903209 positive regulation of oxidative stress-induced cell death
GO:1903210 glomerular visceral epithelial cell apoptotic process
GO:1903320 regulation of protein modification by small protein conjugation or removal
GO:1903321 negative regulation of protein modification by small protein conjugation or removal
GO:1903350 response to dopamine
GO:1903351 cellular response to dopamine
GO:1903522 regulation of blood circulation
GO:1903524 positive regulation of blood circulation
GO:1903532 positive regulation of secretion by cell
GO:1904019 epithelial cell apoptotic process
GO:1904035 regulation of epithelial cell apoptotic process
GO:1904036 negative regulation of epithelial cell apoptotic process
GO:1904062 regulation of cation transmembrane transport
GO:1904064 positive regulation of cation transmembrane transport
GO:1904427 positive regulation of calcium ion transmembrane transport
GO:1904526 regulation of microtubule binding
GO:1904528 positive regulation of microtubule binding
GO:1904529 regulation of actin filament binding
GO:1904531 positive regulation of actin filament binding
GO:1904616 regulation of actin binding
GO:1904618 positive regulation of actin binding
GO:1904951 positive regulation of establishment of protein localization
GO:1905206 positive regulation of hydrogen peroxide-induced cell death
GO:1905330 regulation of morphogenesis of an epithelium
GO:1990051 activation of protein kinase C activity
GO:1990138 neuron projection extension
GO:2000021 regulation of ion homeostasis
GO:2000027 regulation of organ morphogenesis
GO:2000050 regulation of non-canonical Wnt signaling pathway
GO:2000052 positive regulation of non-canonical Wnt signaling pathway
GO:2000095 regulation of Wnt signaling pathway, planar cell polarity pathway
GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2000351 regulation of endothelial cell apoptotic process
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2000772 regulation of cellular senescence
GO:2000773 negative regulation of cellular senescence
GO:2001020 regulation of response to DNA damage stimulus
Molecular Function GO:0000149 SNARE binding
GO:0000287 magnesium ion binding
GO:0003779 actin binding
GO:0003785 actin monomer binding
GO:0004515 nicotinate-nucleotide adenylyltransferase activity
GO:0004713 protein tyrosine kinase activity
GO:0004715 non-membrane spanning protein tyrosine kinase activity
GO:0005080 protein kinase C binding
GO:0008022 protein C-terminus binding
GO:0016779 nucleotidyltransferase activity
GO:0017124 SH3 domain binding
GO:0019905 syntaxin binding
GO:0030145 manganese ion binding
GO:0051015 actin filament binding
GO:0051019 mitogen-activated protein kinase binding
GO:0070064 proline-rich region binding
GO:0070097 delta-catenin binding
GO:0070566 adenylyltransferase activity
Cellular Component GO:0001726 ruffle
GO:0005635 nuclear envelope
GO:0009898 cytoplasmic side of plasma membrane
GO:0015629 actin cytoskeleton
GO:0019897 extrinsic component of plasma membrane
GO:0019898 extrinsic component of membrane
GO:0030426 growth cone
GO:0030427 site of polarized growth
GO:0031234 extrinsic component of cytoplasmic side of plasma membrane
GO:0031252 cell leading edge
GO:0031965 nuclear membrane
GO:0043025 neuronal cell body
GO:0044297 cell body
GO:0098552 side of membrane
GO:0098562 cytoplasmic side of membrane
> KEGG and Reactome Pathway
 
KEGG hsa04012 ErbB signaling pathway
hsa04014 Ras signaling pathway
hsa04110 Cell cycle
hsa04360 Axon guidance
hsa04722 Neurotrophin signaling pathway
Reactome R-HSA-422475: Axon guidance
R-HSA-375170: CDO in myogenesis
R-HSA-5693606: DNA Double Strand Break Response
R-HSA-5693532: DNA Double-Strand Break Repair
R-HSA-73894: DNA Repair
R-HSA-1266738: Developmental Biology
R-HSA-983231: Factors involved in megakaryocyte development and platelet production
R-HSA-2029480: Fcgamma receptor (FCGR) dependent phagocytosis
R-HSA-5693567: HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)
R-HSA-5685938: HDR through Single Strand Annealing (SSA)
R-HSA-109582: Hemostasis
R-HSA-5693538: Homology Directed Repair
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-525793: Myogenesis
R-HSA-195258: RHO GTPase Effectors
R-HSA-5663213: RHO GTPases Activate WASPs and WAVEs
R-HSA-5693565: Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
R-HSA-2029482: Regulation of actin dynamics for phagocytic cup formation
R-HSA-428890: Role of Abl in Robo-Slit signaling
R-HSA-162582: Signal Transduction
R-HSA-194315: Signaling by Rho GTPases
R-HSA-376176: Signaling by Robo receptor
Summary
SymbolABL1
NameABL proto-oncogene 1, non-receptor tyrosine kinase
Aliases JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ......
Chromosomal Location9q34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ABL1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between ABL1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
18326818Chronic Myelogenous Leukemia, BCR-ABL1 PositiveInhibit immunity (T cell function)Development and dynamics of robust T-cell responses to CML under imatinib treatment. Imatinib is the first of a new breed of molecular targeted cancer therapies; it inhibits the abl tyrosine kinase3 and has become the first-line therapy for CML. Our data show that antileukemia T-cell responses develop in the majority of CML patients (9 of 14) in remission and that CD4(+) T cells producing tumor necrosis factor-alpha (median 17.6%) represent the major response over interferon-gamma.
Summary
SymbolABL1
NameABL proto-oncogene 1, non-receptor tyrosine kinase
Aliases JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ......
Chromosomal Location9q34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ABL1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolABL1
NameABL proto-oncogene 1, non-receptor tyrosine kinase
Aliases JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ......
Chromosomal Location9q34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ABL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.0040.984
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0350.986
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0360.981
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0890.85
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.390.879
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2950.931
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.180.661
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.2330.893
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.0920.963
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4620.732
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.2360.507
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0540.467
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ABL1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.44.13.30.61
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.45.12.30.647
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38277.907.90.26
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22139.109.10.519
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolABL1
NameABL proto-oncogene 1, non-receptor tyrosine kinase
Aliases JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ......
Chromosomal Location9q34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ABL1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolABL1
NameABL proto-oncogene 1, non-receptor tyrosine kinase
Aliases JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ......
Chromosomal Location9q34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ABL1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ABL1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolABL1
NameABL proto-oncogene 1, non-receptor tyrosine kinase
Aliases JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ......
Chromosomal Location9q34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ABL1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolABL1
NameABL proto-oncogene 1, non-receptor tyrosine kinase
Aliases JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ......
Chromosomal Location9q34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ABL1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolABL1
NameABL proto-oncogene 1, non-receptor tyrosine kinase
Aliases JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ......
Chromosomal Location9q34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ABL1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolABL1
NameABL proto-oncogene 1, non-receptor tyrosine kinase
Aliases JTK7; c-ABL; v-abl Abelson murine leukemia viral oncogene homolog 1; c-abl oncogene 1, receptor tyrosine kin ......
Chromosomal Location9q34.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ABL1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting ABL1.
ID Name Drug Type Targets #Targets
DB00171ATPSmall MoleculeABCA1, ABCB1, ABCB11, ABCC1, ABCC2, ABCC4, ABCC6, ABCC8, ABCC9, AB ......42
DB00619ImatinibSmall MoleculeABL1, CSF1R, DDR1, KIT, NTRK1, PDGFRA, PDGFRB7
DB01254DasatinibSmall MoleculeABL1, ABL2, BCR, BTK, CSK, EPHA2, EPHA5, EPHB4, FGR, FRK, FYN, HSP ......22
DB03878N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-PyridinecarboxamideSmall MoleculeABL11
DB04868NilotinibSmall MoleculeABL1, KIT2
DB05184XL228Small MoleculeABL1, ABL2, IGF1R, SRC4
DB06616BosutinibSmall MoleculeABL1, BCR, CAMK2G, CDK2, HCK, LYN, MAP2K1, MAP2K2, MAP3K2, SRC10
DB078312-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDESmall MoleculeABL11
DB080431-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREASmall MoleculeABL11
DB08231Myristic acidSmall MoleculeABL1, ARF1, ARF6, ECI2, FKBP1A, GM2A, GUCA1A, HNF4A, INS, LY96, NC ......20
DB083396-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONESmall MoleculeABL11
DB083505-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDESmall MoleculeABL11
DB085832-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamideSmall MoleculeABL11
DB08896RegorafenibSmall MoleculeABL1, BRAF, DDR2, EPHA2, FGFR1, FGFR2, FLT1, FLT4, FRK, KDR, KIT, ......18
DB08901PonatinibSmall MoleculeABL1, BCR, FGFR1, FGFR2, FGFR3, FGFR4, FLT3, KDR, KIT, LCK, LYN, P ......15
DB12267BrigatinibSmall MoleculeABL1, ALK, EGFR, ERBB2, ERBB4, FLT3, IGF1R, INSR, MET9
DB12323RadotinibSmall MoleculeABL11