Summary | |
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Symbol | ACACA |
Name | acetyl-CoA carboxylase alpha |
Aliases | acetyl-CoA carboxylase 1; ACAC; ACC; acetyl-Coenzyme A carboxylase alpha; ACACD; ACC-alpha |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. |
Domain |
PF08326 Acetyl-CoA carboxylase PF02785 Biotin carboxylase C-terminal domain PF00289 Biotin carboxylase PF00364 Biotin-requiring enzyme PF01039 Carboxyl transferase domain PF02786 Carbamoyl-phosphate synthase L chain |
Function |
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. |
Biological Process |
GO:0001894 tissue homeostasis GO:0006084 acetyl-CoA metabolic process GO:0006631 fatty acid metabolic process GO:0006633 fatty acid biosynthetic process GO:0006637 acyl-CoA metabolic process GO:0006732 coenzyme metabolic process GO:0006766 vitamin metabolic process GO:0006767 water-soluble vitamin metabolic process GO:0006768 biotin metabolic process GO:0006790 sulfur compound metabolic process GO:0006820 anion transport GO:0006839 mitochondrial transport GO:0006853 carnitine shuttle GO:0006869 lipid transport GO:0009108 coenzyme biosynthetic process GO:0010876 lipid localization GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015908 fatty acid transport GO:0015909 long-chain fatty acid transport GO:0016053 organic acid biosynthetic process GO:0032365 intracellular lipid transport GO:0034694 response to prostaglandin GO:0034695 response to prostaglandin E GO:0035336 long-chain fatty-acyl-CoA metabolic process GO:0035337 fatty-acyl-CoA metabolic process GO:0035338 long-chain fatty-acyl-CoA biosynthetic process GO:0035383 thioester metabolic process GO:0035384 thioester biosynthetic process GO:0044236 multicellular organism metabolic process GO:0044259 multicellular organismal macromolecule metabolic process GO:0044268 multicellular organismal protein metabolic process GO:0044272 sulfur compound biosynthetic process GO:0044283 small molecule biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0046942 carboxylic acid transport GO:0046949 fatty-acyl-CoA biosynthetic process GO:0048871 multicellular organismal homeostasis GO:0051186 cofactor metabolic process GO:0051188 cofactor biosynthetic process GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051262 protein tetramerization GO:0051289 protein homotetramerization GO:0055088 lipid homeostasis GO:0060249 anatomical structure homeostasis GO:0071379 cellular response to prostaglandin stimulus GO:0071380 cellular response to prostaglandin E stimulus GO:0071616 acyl-CoA biosynthetic process GO:0072330 monocarboxylic acid biosynthetic process GO:0098656 anion transmembrane transport GO:1901654 response to ketone GO:1901655 cellular response to ketone GO:1990542 mitochondrial transmembrane transport GO:2001293 malonyl-CoA metabolic process GO:2001295 malonyl-CoA biosynthetic process |
Molecular Function |
GO:0003989 acetyl-CoA carboxylase activity GO:0004075 biotin carboxylase activity GO:0016421 CoA carboxylase activity GO:0016874 ligase activity GO:0016879 ligase activity, forming carbon-nitrogen bonds GO:0016885 ligase activity, forming carbon-carbon bonds |
Cellular Component |
GO:0015629 actin cytoskeleton |
KEGG |
hsa04152 AMPK signaling pathway hsa04910 Insulin signaling pathway hsa04922 Glucagon signaling pathway hsa00061 Fatty acid biosynthesis hsa00620 Pyruvate metabolism hsa00640 Propanoate metabolism hsa01100 Metabolic pathways hsa01212 Fatty acid metabolism |
Reactome |
R-HSA-2426168: Activation of gene expression by SREBF (SREBP) R-HSA-196780: Biotin transport and metabolism R-HSA-163765: ChREBP activates metabolic gene expression R-HSA-3371599: Defective HLCS causes multiple carboxylase deficiency R-HSA-3323169: Defects in biotin (Btn) metabolism R-HSA-3296482: Defects in vitamin and cofactor metabolism R-HSA-1643685: Disease R-HSA-5668914: Diseases of metabolism R-HSA-75105: Fatty Acyl-CoA Biosynthesis R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-163685: Integration of energy metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-196854: Metabolism of vitamins and cofactors R-HSA-196849: Metabolism of water-soluble vitamins and cofactors R-HSA-1655829: Regulation of cholesterol biosynthesis by SREBP (SREBF) R-HSA-75109: Triglyceride Biosynthesis |
Summary | |
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Symbol | ACACA |
Name | acetyl-CoA carboxylase alpha |
Aliases | acetyl-CoA carboxylase 1; ACAC; ACC; acetyl-Coenzyme A carboxylase alpha; ACACD; ACC-alpha |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ACACA and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ACACA |
Name | acetyl-CoA carboxylase alpha |
Aliases | acetyl-CoA carboxylase 1; ACAC; ACC; acetyl-Coenzyme A carboxylase alpha; ACACD; ACC-alpha |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ACACA in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ACACA |
Name | acetyl-CoA carboxylase alpha |
Aliases | acetyl-CoA carboxylase 1; ACAC; ACC; acetyl-Coenzyme A carboxylase alpha; ACACD; ACC-alpha |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ACACA in various data sets.
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Points in the above scatter plot represent the mutation difference of ACACA in various data sets.
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Summary | |
---|---|
Symbol | ACACA |
Name | acetyl-CoA carboxylase alpha |
Aliases | acetyl-CoA carboxylase 1; ACAC; ACC; acetyl-Coenzyme A carboxylase alpha; ACACD; ACC-alpha |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ACACA. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ACACA |
Name | acetyl-CoA carboxylase alpha |
Aliases | acetyl-CoA carboxylase 1; ACAC; ACC; acetyl-Coenzyme A carboxylase alpha; ACACD; ACC-alpha |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ACACA. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ACACA. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ACACA |
Name | acetyl-CoA carboxylase alpha |
Aliases | acetyl-CoA carboxylase 1; ACAC; ACC; acetyl-Coenzyme A carboxylase alpha; ACACD; ACC-alpha |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ACACA. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ACACA |
Name | acetyl-CoA carboxylase alpha |
Aliases | acetyl-CoA carboxylase 1; ACAC; ACC; acetyl-Coenzyme A carboxylase alpha; ACACD; ACC-alpha |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ACACA expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ACACA |
Name | acetyl-CoA carboxylase alpha |
Aliases | acetyl-CoA carboxylase 1; ACAC; ACC; acetyl-Coenzyme A carboxylase alpha; ACACD; ACC-alpha |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ACACA and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ACACA |
Name | acetyl-CoA carboxylase alpha |
Aliases | acetyl-CoA carboxylase 1; ACAC; ACC; acetyl-Coenzyme A carboxylase alpha; ACACD; ACC-alpha |
Chromosomal Location | 17q12 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ACACA collected from DrugBank database. |
Details on drugs targeting ACACA.
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