Summary | |
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Symbol | ACAP2 |
Name | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 |
Aliases | KIAA0041; CNT-B2; CENTB2; centaurin, beta 2; Arf GAP with coiled coil, ANK repeat and PH domains 2; centauri ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Endosome membrane Peripheral membrane protein |
Domain |
PF12796 Ankyrin repeats (3 copies) PF01412 Putative GTPase activating protein for Arf PF00169 PH domain |
Function |
GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6). |
Biological Process |
GO:0036010 protein localization to endosome GO:0072665 protein localization to vacuole GO:1990089 response to nerve growth factor GO:1990090 cellular response to nerve growth factor stimulus |
Molecular Function |
GO:0005096 GTPase activator activity GO:0008047 enzyme activator activity GO:0017016 Ras GTPase binding GO:0017137 Rab GTPase binding GO:0030695 GTPase regulator activity GO:0031267 small GTPase binding GO:0051020 GTPase binding GO:0060589 nucleoside-triphosphatase regulator activity |
Cellular Component |
GO:0010008 endosome membrane GO:0044440 endosomal part |
KEGG |
hsa04144 Endocytosis |
Reactome | - |
Summary | |
---|---|
Symbol | ACAP2 |
Name | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 |
Aliases | KIAA0041; CNT-B2; CENTB2; centaurin, beta 2; Arf GAP with coiled coil, ANK repeat and PH domains 2; centauri ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ACAP2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ACAP2 |
Name | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 |
Aliases | KIAA0041; CNT-B2; CENTB2; centaurin, beta 2; Arf GAP with coiled coil, ANK repeat and PH domains 2; centauri ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ACAP2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ACAP2 |
Name | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 |
Aliases | KIAA0041; CNT-B2; CENTB2; centaurin, beta 2; Arf GAP with coiled coil, ANK repeat and PH domains 2; centauri ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ACAP2 in various data sets.
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Points in the above scatter plot represent the mutation difference of ACAP2 in various data sets.
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Summary | |
---|---|
Symbol | ACAP2 |
Name | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 |
Aliases | KIAA0041; CNT-B2; CENTB2; centaurin, beta 2; Arf GAP with coiled coil, ANK repeat and PH domains 2; centauri ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ACAP2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ACAP2 |
Name | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 |
Aliases | KIAA0041; CNT-B2; CENTB2; centaurin, beta 2; Arf GAP with coiled coil, ANK repeat and PH domains 2; centauri ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ACAP2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ACAP2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ACAP2 |
Name | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 |
Aliases | KIAA0041; CNT-B2; CENTB2; centaurin, beta 2; Arf GAP with coiled coil, ANK repeat and PH domains 2; centauri ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ACAP2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ACAP2 |
Name | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 |
Aliases | KIAA0041; CNT-B2; CENTB2; centaurin, beta 2; Arf GAP with coiled coil, ANK repeat and PH domains 2; centauri ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ACAP2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ACAP2 |
Name | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 |
Aliases | KIAA0041; CNT-B2; CENTB2; centaurin, beta 2; Arf GAP with coiled coil, ANK repeat and PH domains 2; centauri ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ACAP2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ACAP2 |
Name | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 |
Aliases | KIAA0041; CNT-B2; CENTB2; centaurin, beta 2; Arf GAP with coiled coil, ANK repeat and PH domains 2; centauri ...... |
Chromosomal Location | 3q29 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ACAP2 collected from DrugBank database. |
There is no record. |