Summary | |
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Symbol | ACAT1 |
Name | acetyl-CoA acetyltransferase 1 |
Aliases | THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion. |
Domain |
PF02803 Thiolase PF00108 Thiolase |
Function |
Plays a major role in ketone body metabolism. |
Biological Process |
GO:0001655 urogenital system development GO:0001656 metanephros development GO:0001822 kidney development GO:0001889 liver development GO:0006084 acetyl-CoA metabolic process GO:0006085 acetyl-CoA biosynthetic process GO:0006164 purine nucleotide biosynthetic process GO:0006549 isoleucine metabolic process GO:0006550 isoleucine catabolic process GO:0006631 fatty acid metabolic process GO:0006635 fatty acid beta-oxidation GO:0006637 acyl-CoA metabolic process GO:0006732 coenzyme metabolic process GO:0006790 sulfur compound metabolic process GO:0009062 fatty acid catabolic process GO:0009081 branched-chain amino acid metabolic process GO:0009083 branched-chain amino acid catabolic process GO:0009108 coenzyme biosynthetic process GO:0009109 coenzyme catabolic process GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009163 nucleoside biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0009991 response to extracellular stimulus GO:0015936 coenzyme A metabolic process GO:0015937 coenzyme A biosynthetic process GO:0016042 lipid catabolic process GO:0016054 organic acid catabolic process GO:0019395 fatty acid oxidation GO:0030258 lipid modification GO:0031667 response to nutrient levels GO:0033865 nucleoside bisphosphate metabolic process GO:0033866 nucleoside bisphosphate biosynthetic process GO:0033875 ribonucleoside bisphosphate metabolic process GO:0034030 ribonucleoside bisphosphate biosynthetic process GO:0034032 purine nucleoside bisphosphate metabolic process GO:0034033 purine nucleoside bisphosphate biosynthetic process GO:0034440 lipid oxidation GO:0035383 thioester metabolic process GO:0035384 thioester biosynthetic process GO:0042278 purine nucleoside metabolic process GO:0042451 purine nucleoside biosynthetic process GO:0042455 ribonucleoside biosynthetic process GO:0042594 response to starvation GO:0044242 cellular lipid catabolic process GO:0044272 sulfur compound biosynthetic process GO:0044273 sulfur compound catabolic process GO:0044282 small molecule catabolic process GO:0044283 small molecule biosynthetic process GO:0046128 purine ribonucleoside metabolic process GO:0046129 purine ribonucleoside biosynthetic process GO:0046356 acetyl-CoA catabolic process GO:0046390 ribose phosphate biosynthetic process GO:0046395 carboxylic acid catabolic process GO:0046950 cellular ketone body metabolic process GO:0046951 ketone body biosynthetic process GO:0046952 ketone body catabolic process GO:0048732 gland development GO:0051186 cofactor metabolic process GO:0051187 cofactor catabolic process GO:0051188 cofactor biosynthetic process GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0060612 adipose tissue development GO:0061008 hepaticobiliary system development GO:0061326 renal tubule development GO:0061448 connective tissue development GO:0071616 acyl-CoA biosynthetic process GO:0072001 renal system development GO:0072006 nephron development GO:0072009 nephron epithelium development GO:0072014 proximal tubule development GO:0072019 proximal convoluted tubule development GO:0072073 kidney epithelium development GO:0072080 nephron tubule development GO:0072170 metanephric tubule development GO:0072207 metanephric epithelium development GO:0072229 metanephric proximal convoluted tubule development GO:0072234 metanephric nephron tubule development GO:0072237 metanephric proximal tubule development GO:0072243 metanephric nephron epithelium development GO:0072329 monocarboxylic acid catabolic process GO:0072522 purine-containing compound biosynthetic process GO:1901293 nucleoside phosphate biosynthetic process GO:1901565 organonitrogen compound catabolic process GO:1901605 alpha-amino acid metabolic process GO:1901606 alpha-amino acid catabolic process GO:1901657 glycosyl compound metabolic process GO:1901659 glycosyl compound biosynthetic process GO:1902224 ketone body metabolic process GO:1902858 propionyl-CoA metabolic process GO:1902860 propionyl-CoA biosynthetic process |
Molecular Function |
GO:0003985 acetyl-CoA C-acetyltransferase activity GO:0003988 acetyl-CoA C-acyltransferase activity GO:0016407 acetyltransferase activity GO:0016408 C-acyltransferase activity GO:0016453 C-acetyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0016829 lyase activity GO:0016830 carbon-carbon lyase activity GO:0016874 ligase activity GO:0016885 ligase activity, forming carbon-carbon bonds GO:0048037 cofactor binding GO:0050662 coenzyme binding |
Cellular Component |
GO:0005743 mitochondrial inner membrane GO:0005759 mitochondrial matrix |
KEGG |
hsa00071 Fatty acid degradation hsa00072 Synthesis and degradation of ketone bodies hsa00280 Valine, leucine and isoleucine degradation hsa00310 Lysine degradation hsa00380 Tryptophan metabolism hsa00620 Pyruvate metabolism hsa00630 Glyoxylate and dicarboxylate metabolism hsa00640 Propanoate metabolism hsa00650 Butanoate metabolism hsa00900 Terpenoid backbone biosynthesis hsa01100 Metabolic pathways hsa01200 Carbon metabolism hsa01212 Fatty acid metabolism |
Reactome |
R-HSA-70895: Branched-chain amino acid catabolism R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-74182: Ketone body metabolism R-HSA-1430728: Metabolism R-HSA-71291: Metabolism of amino acids and derivatives R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-77111: Synthesis of Ketone Bodies R-HSA-77108: Utilization of Ketone Bodies |
Summary | |
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Symbol | ACAT1 |
Name | acetyl-CoA acetyltransferase 1 |
Aliases | THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ACAT1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ACAT1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ACAT1 |
Name | acetyl-CoA acetyltransferase 1 |
Aliases | THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ACAT1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ACAT1 |
Name | acetyl-CoA acetyltransferase 1 |
Aliases | THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ACAT1 in various data sets.
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There is no record. |
Summary | |
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Symbol | ACAT1 |
Name | acetyl-CoA acetyltransferase 1 |
Aliases | THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ACAT1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ACAT1 |
Name | acetyl-CoA acetyltransferase 1 |
Aliases | THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ACAT1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ACAT1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ACAT1 |
Name | acetyl-CoA acetyltransferase 1 |
Aliases | THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ACAT1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ACAT1 |
Name | acetyl-CoA acetyltransferase 1 |
Aliases | THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ACAT1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ACAT1 |
Name | acetyl-CoA acetyltransferase 1 |
Aliases | THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ACAT1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ACAT1 |
Name | acetyl-CoA acetyltransferase 1 |
Aliases | THIL; acetyl-Coenzyme A acetyltransferase 1; acetoacetyl-CoA thiolase; mitochondrial acetoacetyl-CoA thiolas ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ACAT1 collected from DrugBank database. |
Details on drugs targeting ACAT1.
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