Summary | |
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Symbol | ACOX2 |
Name | acyl-CoA oxidase 2, branched chain |
Aliases | BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ...... |
Chromosomal Location | 3p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Peroxisome |
Domain |
PF01756 Acyl-CoA oxidase PF02770 Acyl-CoA dehydrogenase PF14749 Acyl-coenzyme A oxidase N-terminal |
Function |
Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids. |
Biological Process |
GO:0006631 fatty acid metabolic process GO:0006635 fatty acid beta-oxidation GO:0006694 steroid biosynthetic process GO:0006699 bile acid biosynthetic process GO:0008202 steroid metabolic process GO:0008206 bile acid metabolic process GO:0009062 fatty acid catabolic process GO:0016042 lipid catabolic process GO:0016053 organic acid biosynthetic process GO:0016054 organic acid catabolic process GO:0019395 fatty acid oxidation GO:0030258 lipid modification GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase GO:0034440 lipid oxidation GO:0044242 cellular lipid catabolic process GO:0044282 small molecule catabolic process GO:0044283 small molecule biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0046395 carboxylic acid catabolic process GO:0055088 lipid homeostasis GO:0072329 monocarboxylic acid catabolic process GO:0072330 monocarboxylic acid biosynthetic process |
Molecular Function |
GO:0000062 fatty-acyl-CoA binding GO:0003995 acyl-CoA dehydrogenase activity GO:0003997 acyl-CoA oxidase activity GO:0009055 electron carrier activity GO:0016402 pristanoyl-CoA oxidase activity GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor GO:0016725 oxidoreductase activity, acting on CH or CH2 groups GO:0033791 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity GO:0048037 cofactor binding GO:0050660 flavin adenine dinucleotide binding GO:0050662 coenzyme binding GO:0052890 oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor GO:1901681 sulfur compound binding |
Cellular Component |
GO:0005777 peroxisome GO:0005782 peroxisomal matrix GO:0031907 microbody lumen GO:0042579 microbody GO:0044438 microbody part GO:0044439 peroxisomal part |
KEGG |
hsa03320 PPAR signaling pathway hsa04146 Peroxisome hsa00120 Primary bile acid biosynthesis hsa01100 Metabolic pathways |
Reactome |
R-HSA-389887: Beta-oxidation of pristanoyl-CoA R-HSA-194068: Bile acid and bile salt metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-390918: Peroxisomal lipid metabolism R-HSA-192105: Synthesis of bile acids and bile salts R-HSA-193368: Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
Summary | |
---|---|
Symbol | ACOX2 |
Name | acyl-CoA oxidase 2, branched chain |
Aliases | BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ...... |
Chromosomal Location | 3p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ACOX2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ACOX2 |
Name | acyl-CoA oxidase 2, branched chain |
Aliases | BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ...... |
Chromosomal Location | 3p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ACOX2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ACOX2 |
Name | acyl-CoA oxidase 2, branched chain |
Aliases | BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ...... |
Chromosomal Location | 3p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ACOX2 in various data sets.
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Points in the above scatter plot represent the mutation difference of ACOX2 in various data sets.
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Summary | |
---|---|
Symbol | ACOX2 |
Name | acyl-CoA oxidase 2, branched chain |
Aliases | BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ...... |
Chromosomal Location | 3p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ACOX2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ACOX2 |
Name | acyl-CoA oxidase 2, branched chain |
Aliases | BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ...... |
Chromosomal Location | 3p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ACOX2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ACOX2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ACOX2 |
Name | acyl-CoA oxidase 2, branched chain |
Aliases | BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ...... |
Chromosomal Location | 3p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ACOX2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ACOX2 |
Name | acyl-CoA oxidase 2, branched chain |
Aliases | BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ...... |
Chromosomal Location | 3p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ACOX2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ACOX2 |
Name | acyl-CoA oxidase 2, branched chain |
Aliases | BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ...... |
Chromosomal Location | 3p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ACOX2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ACOX2 |
Name | acyl-CoA oxidase 2, branched chain |
Aliases | BRCOX; THCCox; trihydroxycoprostanoyl-CoA oxidase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-C ...... |
Chromosomal Location | 3p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ACOX2 collected from DrugBank database. |
There is no record. |