Summary | |
---|---|
Symbol | ACPP |
Name | acid phosphatase, prostate |
Aliases | ACP3; ACP-3; prostatic acid phosphatase; TMPase; prostatic acid phosphotase; thiamine monophosphatase |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Secreted ; SUBCELLULAR LOCATION: Isoform 2: Cell membrane Single-pass type I membrane protein Lysosome membrane Single-pass type I membrane protein Note=Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles (PubMed:17638863). Colocalizes with LAMP2 on the lysosome membrane (PubMed:17897319). |
Domain |
PF00328 Histidine phosphatase superfamily (branch 2) |
Function |
A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins. Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma.; FUNCTION: Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor. Acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling. |
Biological Process |
GO:0001973 adenosine receptor signaling pathway GO:0006144 purine nucleobase metabolic process GO:0006766 vitamin metabolic process GO:0006767 water-soluble vitamin metabolic process GO:0006772 thiamine metabolic process GO:0006790 sulfur compound metabolic process GO:0008277 regulation of G-protein coupled receptor protein signaling pathway GO:0009112 nucleobase metabolic process GO:0009116 nucleoside metabolic process GO:0009119 ribonucleoside metabolic process GO:0016311 dephosphorylation GO:0019233 sensory perception of pain GO:0031644 regulation of neurological system process GO:0035587 purinergic receptor signaling pathway GO:0035588 G-protein coupled purinergic receptor signaling pathway GO:0042278 purine nucleoside metabolic process GO:0042723 thiamine-containing compound metabolic process GO:0044057 regulation of system process GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway GO:0046085 adenosine metabolic process GO:0046128 purine ribonucleoside metabolic process GO:0051930 regulation of sensory perception of pain GO:0051931 regulation of sensory perception GO:0060167 regulation of adenosine receptor signaling pathway GO:0060168 positive regulation of adenosine receptor signaling pathway GO:0072527 pyrimidine-containing compound metabolic process GO:1901657 glycosyl compound metabolic process |
Molecular Function |
GO:0003993 acid phosphatase activity GO:0008252 nucleotidase activity GO:0008253 5'-nucleotidase activity GO:0016791 phosphatase activity GO:0042131 thiamine phosphate phosphatase activity GO:0042578 phosphoric ester hydrolase activity GO:0052642 lysophosphatidic acid phosphatase activity |
Cellular Component |
GO:0005765 lysosomal membrane GO:0030175 filopodium GO:0098852 lytic vacuole membrane GO:0098858 actin-based cell projection |
KEGG | - |
Reactome |
R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-6798695: Neutrophil degranulation |
Summary | |
---|---|
Symbol | ACPP |
Name | acid phosphatase, prostate |
Aliases | ACP3; ACP-3; prostatic acid phosphatase; TMPase; prostatic acid phosphotase; thiamine monophosphatase |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ACPP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ACPP and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | ACPP |
Name | acid phosphatase, prostate |
Aliases | ACP3; ACP-3; prostatic acid phosphatase; TMPase; prostatic acid phosphotase; thiamine monophosphatase |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of ACPP in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | ACPP |
Name | acid phosphatase, prostate |
Aliases | ACP3; ACP-3; prostatic acid phosphatase; TMPase; prostatic acid phosphotase; thiamine monophosphatase |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ACPP in various data sets.
|
Points in the above scatter plot represent the mutation difference of ACPP in various data sets.
|
Summary | |
---|---|
Symbol | ACPP |
Name | acid phosphatase, prostate |
Aliases | ACP3; ACP-3; prostatic acid phosphatase; TMPase; prostatic acid phosphotase; thiamine monophosphatase |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ACPP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ACPP |
Name | acid phosphatase, prostate |
Aliases | ACP3; ACP-3; prostatic acid phosphatase; TMPase; prostatic acid phosphotase; thiamine monophosphatase |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ACPP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ACPP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ACPP |
Name | acid phosphatase, prostate |
Aliases | ACP3; ACP-3; prostatic acid phosphatase; TMPase; prostatic acid phosphotase; thiamine monophosphatase |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ACPP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ACPP |
Name | acid phosphatase, prostate |
Aliases | ACP3; ACP-3; prostatic acid phosphatase; TMPase; prostatic acid phosphotase; thiamine monophosphatase |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ACPP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ACPP |
Name | acid phosphatase, prostate |
Aliases | ACP3; ACP-3; prostatic acid phosphatase; TMPase; prostatic acid phosphotase; thiamine monophosphatase |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ACPP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ACPP |
Name | acid phosphatase, prostate |
Aliases | ACP3; ACP-3; prostatic acid phosphatase; TMPase; prostatic acid phosphotase; thiamine monophosphatase |
Chromosomal Location | 3q22.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ACPP collected from DrugBank database. |
Details on drugs targeting ACPP.
|