Summary | |
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Symbol | ACSBG1 |
Name | acyl-CoA synthetase bubblegum family member 1 |
Aliases | BGM; FLJ30320; MGC14352; BG1; KIAA0631; hsBG; bubblegum; lipidosin; GR-LACS; hsBGM; Long-chain-fatty-acid--C ...... |
Chromosomal Location | 15q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Cytoplasmic vesicle Microsome Endoplasmic reticulum |
Domain |
PF00501 AMP-binding enzyme |
Function |
Mediates activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Able to activate long-chain fatty acids. Also able to activate very long-chain fatty acids; however, the relevance of such activity is unclear in vivo. Can activate diverse saturated, monosaturated and polyunsaturated fatty acids. |
Biological Process |
GO:0000038 very long-chain fatty acid metabolic process GO:0001676 long-chain fatty acid metabolic process GO:0006631 fatty acid metabolic process GO:0006637 acyl-CoA metabolic process GO:0006732 coenzyme metabolic process GO:0006790 sulfur compound metabolic process GO:0007272 ensheathment of neurons GO:0008366 axon ensheathment GO:0009108 coenzyme biosynthetic process GO:0031960 response to corticosteroid GO:0035336 long-chain fatty-acyl-CoA metabolic process GO:0035337 fatty-acyl-CoA metabolic process GO:0035338 long-chain fatty-acyl-CoA biosynthetic process GO:0035383 thioester metabolic process GO:0035384 thioester biosynthetic process GO:0042552 myelination GO:0044272 sulfur compound biosynthetic process GO:0046949 fatty-acyl-CoA biosynthetic process GO:0048545 response to steroid hormone GO:0051186 cofactor metabolic process GO:0051188 cofactor biosynthetic process GO:0051384 response to glucocorticoid GO:0071616 acyl-CoA biosynthetic process |
Molecular Function |
GO:0004467 long-chain fatty acid-CoA ligase activity GO:0015645 fatty acid ligase activity GO:0016874 ligase activity GO:0016877 ligase activity, forming carbon-sulfur bonds GO:0016878 acid-thiol ligase activity GO:0031957 very long-chain fatty acid-CoA ligase activity GO:0102391 decanoate--CoA ligase activity |
Cellular Component | - |
KEGG |
hsa03320 PPAR signaling pathway hsa04920 Adipocytokine signaling pathway hsa00061 Fatty acid biosynthesis hsa00071 Fatty acid degradation hsa01100 Metabolic pathways hsa01212 Fatty acid metabolism |
Reactome |
R-HSA-75105: Fatty Acyl-CoA Biosynthesis R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-75876: Synthesis of very long-chain fatty acyl-CoAs R-HSA-75109: Triglyceride Biosynthesis |
Summary | |
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Symbol | ACSBG1 |
Name | acyl-CoA synthetase bubblegum family member 1 |
Aliases | BGM; FLJ30320; MGC14352; BG1; KIAA0631; hsBG; bubblegum; lipidosin; GR-LACS; hsBGM; Long-chain-fatty-acid--C ...... |
Chromosomal Location | 15q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ACSBG1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ACSBG1 |
Name | acyl-CoA synthetase bubblegum family member 1 |
Aliases | BGM; FLJ30320; MGC14352; BG1; KIAA0631; hsBG; bubblegum; lipidosin; GR-LACS; hsBGM; Long-chain-fatty-acid--C ...... |
Chromosomal Location | 15q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ACSBG1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ACSBG1 |
Name | acyl-CoA synthetase bubblegum family member 1 |
Aliases | BGM; FLJ30320; MGC14352; BG1; KIAA0631; hsBG; bubblegum; lipidosin; GR-LACS; hsBGM; Long-chain-fatty-acid--C ...... |
Chromosomal Location | 15q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ACSBG1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ACSBG1 in various data sets.
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Summary | |
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Symbol | ACSBG1 |
Name | acyl-CoA synthetase bubblegum family member 1 |
Aliases | BGM; FLJ30320; MGC14352; BG1; KIAA0631; hsBG; bubblegum; lipidosin; GR-LACS; hsBGM; Long-chain-fatty-acid--C ...... |
Chromosomal Location | 15q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ACSBG1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ACSBG1 |
Name | acyl-CoA synthetase bubblegum family member 1 |
Aliases | BGM; FLJ30320; MGC14352; BG1; KIAA0631; hsBG; bubblegum; lipidosin; GR-LACS; hsBGM; Long-chain-fatty-acid--C ...... |
Chromosomal Location | 15q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ACSBG1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ACSBG1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ACSBG1 |
Name | acyl-CoA synthetase bubblegum family member 1 |
Aliases | BGM; FLJ30320; MGC14352; BG1; KIAA0631; hsBG; bubblegum; lipidosin; GR-LACS; hsBGM; Long-chain-fatty-acid--C ...... |
Chromosomal Location | 15q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ACSBG1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ACSBG1 |
Name | acyl-CoA synthetase bubblegum family member 1 |
Aliases | BGM; FLJ30320; MGC14352; BG1; KIAA0631; hsBG; bubblegum; lipidosin; GR-LACS; hsBGM; Long-chain-fatty-acid--C ...... |
Chromosomal Location | 15q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ACSBG1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ACSBG1 |
Name | acyl-CoA synthetase bubblegum family member 1 |
Aliases | BGM; FLJ30320; MGC14352; BG1; KIAA0631; hsBG; bubblegum; lipidosin; GR-LACS; hsBGM; Long-chain-fatty-acid--C ...... |
Chromosomal Location | 15q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ACSBG1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ACSBG1 |
Name | acyl-CoA synthetase bubblegum family member 1 |
Aliases | BGM; FLJ30320; MGC14352; BG1; KIAA0631; hsBG; bubblegum; lipidosin; GR-LACS; hsBGM; Long-chain-fatty-acid--C ...... |
Chromosomal Location | 15q23-q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ACSBG1 collected from DrugBank database. |
Details on drugs targeting ACSBG1.
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