Summary | |
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Symbol | ACSM2A |
Name | acyl-CoA synthetase medium-chain family member 2A |
Aliases | A-923A4.1; MGC150530; Homolog of rat kidney-specific (KS); butyrate--CoA ligase 2A; butyryl-coenzyme A synth ...... |
Chromosomal Location | 16p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion matrix |
Domain |
PF00501 AMP-binding enzyme PF13193 AMP-binding enzyme C-terminal domain |
Function |
Has medium-chain fatty acid:CoA ligase activity with broad substrate specificity (in vitro). Acts on acids from C(4) to C(11) and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids (in vitro) (By similarity). |
Biological Process |
GO:0006631 fatty acid metabolic process GO:0006637 acyl-CoA metabolic process GO:0006732 coenzyme metabolic process GO:0006790 sulfur compound metabolic process GO:0033500 carbohydrate homeostasis GO:0035337 fatty-acyl-CoA metabolic process GO:0035383 thioester metabolic process GO:0036112 medium-chain fatty-acyl-CoA metabolic process GO:0042593 glucose homeostasis GO:0051186 cofactor metabolic process GO:0055088 lipid homeostasis GO:0055090 acylglycerol homeostasis GO:0070328 triglyceride homeostasis |
Molecular Function |
GO:0016874 ligase activity GO:0016877 ligase activity, forming carbon-sulfur bonds GO:0016878 acid-thiol ligase activity GO:0047760 butyrate-CoA ligase activity |
Cellular Component |
GO:0005759 mitochondrial matrix |
KEGG |
hsa00650 Butanoate metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-156587: Amino Acid conjugation R-HSA-211859: Biological oxidations R-HSA-159424: Conjugation of carboxylic acids R-HSA-177128: Conjugation of salicylate with glycine R-HSA-1430728: Metabolism R-HSA-156580: Phase II conjugation |
Summary | |
---|---|
Symbol | ACSM2A |
Name | acyl-CoA synthetase medium-chain family member 2A |
Aliases | A-923A4.1; MGC150530; Homolog of rat kidney-specific (KS); butyrate--CoA ligase 2A; butyryl-coenzyme A synth ...... |
Chromosomal Location | 16p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ACSM2A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ACSM2A |
Name | acyl-CoA synthetase medium-chain family member 2A |
Aliases | A-923A4.1; MGC150530; Homolog of rat kidney-specific (KS); butyrate--CoA ligase 2A; butyryl-coenzyme A synth ...... |
Chromosomal Location | 16p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ACSM2A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ACSM2A |
Name | acyl-CoA synthetase medium-chain family member 2A |
Aliases | A-923A4.1; MGC150530; Homolog of rat kidney-specific (KS); butyrate--CoA ligase 2A; butyryl-coenzyme A synth ...... |
Chromosomal Location | 16p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ACSM2A in various data sets.
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Points in the above scatter plot represent the mutation difference of ACSM2A in various data sets.
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Summary | |
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Symbol | ACSM2A |
Name | acyl-CoA synthetase medium-chain family member 2A |
Aliases | A-923A4.1; MGC150530; Homolog of rat kidney-specific (KS); butyrate--CoA ligase 2A; butyryl-coenzyme A synth ...... |
Chromosomal Location | 16p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ACSM2A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ACSM2A |
Name | acyl-CoA synthetase medium-chain family member 2A |
Aliases | A-923A4.1; MGC150530; Homolog of rat kidney-specific (KS); butyrate--CoA ligase 2A; butyryl-coenzyme A synth ...... |
Chromosomal Location | 16p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ACSM2A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ACSM2A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ACSM2A |
Name | acyl-CoA synthetase medium-chain family member 2A |
Aliases | A-923A4.1; MGC150530; Homolog of rat kidney-specific (KS); butyrate--CoA ligase 2A; butyryl-coenzyme A synth ...... |
Chromosomal Location | 16p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ACSM2A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ACSM2A |
Name | acyl-CoA synthetase medium-chain family member 2A |
Aliases | A-923A4.1; MGC150530; Homolog of rat kidney-specific (KS); butyrate--CoA ligase 2A; butyryl-coenzyme A synth ...... |
Chromosomal Location | 16p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ACSM2A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ACSM2A |
Name | acyl-CoA synthetase medium-chain family member 2A |
Aliases | A-923A4.1; MGC150530; Homolog of rat kidney-specific (KS); butyrate--CoA ligase 2A; butyryl-coenzyme A synth ...... |
Chromosomal Location | 16p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ACSM2A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ACSM2A |
Name | acyl-CoA synthetase medium-chain family member 2A |
Aliases | A-923A4.1; MGC150530; Homolog of rat kidney-specific (KS); butyrate--CoA ligase 2A; butyryl-coenzyme A synth ...... |
Chromosomal Location | 16p12.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ACSM2A collected from DrugBank database. |
There is no record. |