Summary | |
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Symbol | ACTA2 |
Name | actin, alpha 2, smooth muscle, aorta |
Aliases | ACTSA; AAT6; MYMY5; cell growth-inhibiting gene 46 protein; Alpha-actin-2; Actin, aortic smooth muscle |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm, cytoskeleton. |
Domain |
PF00022 Actin |
Function |
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
Biological Process |
GO:0001655 urogenital system development GO:0001822 kidney development GO:0002064 epithelial cell development GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0006936 muscle contraction GO:0006939 smooth muscle contraction GO:0008015 blood circulation GO:0008217 regulation of blood pressure GO:0009615 response to virus GO:0014829 vascular smooth muscle contraction GO:0032835 glomerulus development GO:0035150 regulation of tube size GO:0035850 epithelial cell differentiation involved in kidney development GO:0042310 vasoconstriction GO:0050880 regulation of blood vessel size GO:0060485 mesenchyme development GO:0061005 cell differentiation involved in kidney development GO:0061437 renal system vasculature development GO:0061440 kidney vasculature development GO:0061448 connective tissue development GO:0072001 renal system development GO:0072006 nephron development GO:0072007 mesangial cell differentiation GO:0072008 glomerular mesangial cell differentiation GO:0072012 glomerulus vasculature development GO:0072109 glomerular mesangium development GO:0072132 mesenchyme morphogenesis GO:0072143 mesangial cell development GO:0072144 glomerular mesangial cell development GO:0090066 regulation of anatomical structure size GO:0090130 tissue migration GO:0090131 mesenchyme migration GO:1904238 pericyte cell differentiation |
Molecular Function | - |
Cellular Component |
GO:0015629 actin cytoskeleton GO:0030027 lamellipodium GO:0030175 filopodium GO:0030485 smooth muscle contractile fiber GO:0031252 cell leading edge GO:0043292 contractile fiber GO:0044297 cell body GO:0044449 contractile fiber part GO:0098858 actin-based cell projection |
KEGG |
hsa04270 Vascular smooth muscle contraction |
Reactome |
R-HSA-397014: Muscle contraction R-HSA-445355: Smooth Muscle Contraction |
Summary | |
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Symbol | ACTA2 |
Name | actin, alpha 2, smooth muscle, aorta |
Aliases | ACTSA; AAT6; MYMY5; cell growth-inhibiting gene 46 protein; Alpha-actin-2; Actin, aortic smooth muscle |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ACTA2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | ACTA2 |
Name | actin, alpha 2, smooth muscle, aorta |
Aliases | ACTSA; AAT6; MYMY5; cell growth-inhibiting gene 46 protein; Alpha-actin-2; Actin, aortic smooth muscle |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ACTA2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ACTA2 |
Name | actin, alpha 2, smooth muscle, aorta |
Aliases | ACTSA; AAT6; MYMY5; cell growth-inhibiting gene 46 protein; Alpha-actin-2; Actin, aortic smooth muscle |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ACTA2 in various data sets.
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Points in the above scatter plot represent the mutation difference of ACTA2 in various data sets.
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Summary | |
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Symbol | ACTA2 |
Name | actin, alpha 2, smooth muscle, aorta |
Aliases | ACTSA; AAT6; MYMY5; cell growth-inhibiting gene 46 protein; Alpha-actin-2; Actin, aortic smooth muscle |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ACTA2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ACTA2 |
Name | actin, alpha 2, smooth muscle, aorta |
Aliases | ACTSA; AAT6; MYMY5; cell growth-inhibiting gene 46 protein; Alpha-actin-2; Actin, aortic smooth muscle |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ACTA2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ACTA2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ACTA2 |
Name | actin, alpha 2, smooth muscle, aorta |
Aliases | ACTSA; AAT6; MYMY5; cell growth-inhibiting gene 46 protein; Alpha-actin-2; Actin, aortic smooth muscle |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ACTA2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ACTA2 |
Name | actin, alpha 2, smooth muscle, aorta |
Aliases | ACTSA; AAT6; MYMY5; cell growth-inhibiting gene 46 protein; Alpha-actin-2; Actin, aortic smooth muscle |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ACTA2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ACTA2 |
Name | actin, alpha 2, smooth muscle, aorta |
Aliases | ACTSA; AAT6; MYMY5; cell growth-inhibiting gene 46 protein; Alpha-actin-2; Actin, aortic smooth muscle |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ACTA2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ACTA2 |
Name | actin, alpha 2, smooth muscle, aorta |
Aliases | ACTSA; AAT6; MYMY5; cell growth-inhibiting gene 46 protein; Alpha-actin-2; Actin, aortic smooth muscle |
Chromosomal Location | 10q23.31 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ACTA2 collected from DrugBank database. |
Details on drugs targeting ACTA2.
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