Summary | |
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Symbol | ACVR1C |
Name | activin A receptor, type IC |
Aliases | ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Single-pass type I membrane protein |
Domain |
PF07714 Protein tyrosine kinase PF08515 Transforming growth factor beta type I GS-motif |
Function |
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. |
Biological Process |
GO:0001667 ameboidal-type cell migration GO:0002021 response to dietary excess GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0002792 negative regulation of peptide secretion GO:0006921 cellular component disassembly involved in execution phase of apoptosis GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway GO:0007565 female pregnancy GO:0007566 embryo implantation GO:0009306 protein secretion GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009914 hormone transport GO:0009991 response to extracellular stimulus GO:0010817 regulation of hormone levels GO:0010876 lipid localization GO:0010950 positive regulation of endopeptidase activity GO:0010952 positive regulation of peptidase activity GO:0015833 peptide transport GO:0019915 lipid storage GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0030262 apoptotic nuclear changes GO:0030336 negative regulation of cell migration GO:0031667 response to nutrient levels GO:0032868 response to insulin GO:0032924 activin receptor signaling pathway GO:0034284 response to monosaccharide GO:0038092 nodal signaling pathway GO:0040013 negative regulation of locomotion GO:0042886 amide transport GO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043434 response to peptide hormone GO:0043900 regulation of multi-organism process GO:0043901 negative regulation of multi-organism process GO:0044706 multi-multicellular organism process GO:0045862 positive regulation of proteolysis GO:0046676 negative regulation of insulin secretion GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0046888 negative regulation of hormone secretion GO:0050708 regulation of protein secretion GO:0050709 negative regulation of protein secretion GO:0050796 regulation of insulin secretion GO:0051048 negative regulation of secretion GO:0051051 negative regulation of transport GO:0051224 negative regulation of protein transport GO:0051235 maintenance of location GO:0051271 negative regulation of cellular component movement GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0061450 trophoblast cell migration GO:0090087 regulation of peptide transport GO:0090276 regulation of peptide hormone secretion GO:0090278 negative regulation of peptide hormone secretion GO:0097194 execution phase of apoptosis GO:0097360 chorionic trophoblast cell proliferation GO:1901163 regulation of trophoblast cell migration GO:1901164 negative regulation of trophoblast cell migration GO:1901382 regulation of chorionic trophoblast cell proliferation GO:1901383 negative regulation of chorionic trophoblast cell proliferation GO:1901652 response to peptide GO:1903531 negative regulation of secretion by cell GO:1904950 negative regulation of establishment of protein localization GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000146 negative regulation of cell motility GO:2000241 regulation of reproductive process GO:2000242 negative regulation of reproductive process GO:2001056 positive regulation of cysteine-type endopeptidase activity |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004675 transmembrane receptor protein serine/threonine kinase activity GO:0004702 receptor signaling protein serine/threonine kinase activity GO:0005057 receptor signaling protein activity GO:0016361 activin receptor activity, type I GO:0017002 activin-activated receptor activity GO:0019199 transmembrane receptor protein kinase activity GO:0019838 growth factor binding GO:0038100 nodal binding |
Cellular Component |
GO:0043235 receptor complex GO:0048179 activin receptor complex GO:0061695 transferase complex, transferring phosphorus-containing groups GO:0098802 plasma membrane receptor complex GO:1902554 serine/threonine protein kinase complex GO:1902911 protein kinase complex |
KEGG |
hsa04350 TGF-beta signaling pathway hsa04550 Signaling pathways regulating pluripotency of stem cells |
Reactome |
R-HSA-1266738: Developmental Biology R-HSA-1433617: Regulation of signaling by NODAL R-HSA-162582: Signal Transduction R-HSA-1502540: Signaling by Activin R-HSA-1181150: Signaling by NODAL |
Summary | |
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Symbol | ACVR1C |
Name | activin A receptor, type IC |
Aliases | ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ACVR1C and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ACVR1C |
Name | activin A receptor, type IC |
Aliases | ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ACVR1C in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ACVR1C |
Name | activin A receptor, type IC |
Aliases | ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ACVR1C in various data sets.
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Points in the above scatter plot represent the mutation difference of ACVR1C in various data sets.
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Summary | |
---|---|
Symbol | ACVR1C |
Name | activin A receptor, type IC |
Aliases | ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ACVR1C. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ACVR1C |
Name | activin A receptor, type IC |
Aliases | ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ACVR1C. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ACVR1C. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ACVR1C |
Name | activin A receptor, type IC |
Aliases | ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ACVR1C. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ACVR1C |
Name | activin A receptor, type IC |
Aliases | ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ACVR1C expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ACVR1C |
Name | activin A receptor, type IC |
Aliases | ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ACVR1C and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ACVR1C |
Name | activin A receptor, type IC |
Aliases | ALK7; ACVRLK7; ACTR-IC; ALK-7; activin receptor type IC; activin receptor-like kinase 7; Activin receptor ty ...... |
Chromosomal Location | 2q24.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ACVR1C collected from DrugBank database. |
There is no record. |