Summary | |
---|---|
Symbol | ADAM10 |
Name | ADAM metallopeptidase domain 10 |
Aliases | kuz; HsT18717; CD156c; a disintegrin and metalloproteinase domain 10; AD10; AD18; CDw156; a disintegrin and ...... |
Chromosomal Location | 15q2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Golgi apparatus membrane Single-pass type I membrane protein Note=Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi. |
Domain |
PF00200 Disintegrin PF01562 Reprolysin family propeptide |
Function |
Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (PubMed:20592283). Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) (PubMed:26686862, PubMed:11786905). Contributes to the normal cleavage of the cellular prion protein (PubMed:11477090). Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity (PubMed:12475894). Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form (PubMed:17557115). Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B (PubMed:19114711, PubMed:21288900). May regulate the EFNA5-EPHA3 signaling (PubMed:16239146). |
Biological Process |
GO:0001558 regulation of cell growth GO:0001701 in utero embryonic development GO:0002274 myeloid leukocyte activation GO:0002685 regulation of leukocyte migration GO:0002687 positive regulation of leukocyte migration GO:0002688 regulation of leukocyte chemotaxis GO:0002690 positive regulation of leukocyte chemotaxis GO:0006509 membrane protein ectodomain proteolysis GO:0007162 negative regulation of cell adhesion GO:0007219 Notch signaling pathway GO:0007220 Notch receptor processing GO:0007229 integrin-mediated signaling pathway GO:0010818 T cell chemotaxis GO:0010819 regulation of T cell chemotaxis GO:0010820 positive regulation of T cell chemotaxis GO:0016049 cell growth GO:0016485 protein processing GO:0022617 extracellular matrix disassembly GO:0030198 extracellular matrix organization GO:0030307 positive regulation of cell growth GO:0030335 positive regulation of cell migration GO:0030595 leukocyte chemotaxis GO:0032103 positive regulation of response to external stimulus GO:0033619 membrane protein proteolysis GO:0034612 response to tumor necrosis factor GO:0040017 positive regulation of locomotion GO:0042117 monocyte activation GO:0043062 extracellular structure organization GO:0045927 positive regulation of growth GO:0048013 ephrin receptor signaling pathway GO:0048247 lymphocyte chemotaxis GO:0050900 leukocyte migration GO:0050920 regulation of chemotaxis GO:0050921 positive regulation of chemotaxis GO:0051088 PMA-inducible membrane protein ectodomain proteolysis GO:0051089 constitutive protein ectodomain proteolysis GO:0051272 positive regulation of cellular component movement GO:0051604 protein maturation GO:0060326 cell chemotaxis GO:0072676 lymphocyte migration GO:0072678 T cell migration GO:1901623 regulation of lymphocyte chemotaxis GO:2000147 positive regulation of cell motility GO:2000401 regulation of lymphocyte migration GO:2000403 positive regulation of lymphocyte migration GO:2000404 regulation of T cell migration GO:2000406 positive regulation of T cell migration |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004222 metalloendopeptidase activity GO:0005178 integrin binding GO:0008237 metallopeptidase activity GO:0017124 SH3 domain binding GO:0050839 cell adhesion molecule binding |
Cellular Component |
GO:0005798 Golgi-associated vesicle GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0014069 postsynaptic density GO:0030055 cell-substrate junction GO:0060076 excitatory synapse GO:0097038 perinuclear endoplasmic reticulum GO:0097197 tetraspanin-enriched microdomain GO:0098794 postsynapse GO:0099572 postsynaptic specialization |
KEGG | - |
Reactome |
R-HSA-2122948: Activated NOTCH1 Transmits Signal to the Nucleus R-HSA-422475: Axon guidance R-HSA-1442490: Collagen degradation R-HSA-2691232: Constitutive Signaling by NOTCH1 HD Domain Mutants R-HSA-2894862: Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants R-HSA-2644606: Constitutive Signaling by NOTCH1 PEST Domain Mutants R-HSA-2660826: Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1 R-HSA-1474228: Degradation of the extracellular matrix R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-2682334: EPH-Ephrin signaling R-HSA-3928665: EPH-ephrin mediated repulsion of cells R-HSA-1474244: Extracellular matrix organization R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-2979096: NOTCH2 Activation and Transmission of Signal to the Nucleus R-HSA-6798695: Neutrophil degranulation R-HSA-156988: Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-157118: Signaling by NOTCH R-HSA-1980143: Signaling by NOTCH1 R-HSA-2691230: Signaling by NOTCH1 HD Domain Mutants in Cancer R-HSA-2894858: Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer R-HSA-2644602: Signaling by NOTCH1 PEST Domain Mutants in Cancer R-HSA-2644603: Signaling by NOTCH1 in Cancer R-HSA-2660825: Signaling by NOTCH1 t(7;9)(NOTCH1 R-HSA-1980145: Signaling by NOTCH2 R-HSA-1980148: Signaling by NOTCH3 R-HSA-1980150: Signaling by NOTCH4 |
Summary | |
---|---|
Symbol | ADAM10 |
Name | ADAM metallopeptidase domain 10 |
Aliases | kuz; HsT18717; CD156c; a disintegrin and metalloproteinase domain 10; AD10; AD18; CDw156; a disintegrin and ...... |
Chromosomal Location | 15q2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ADAM10 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ADAM10 and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | ADAM10 |
Name | ADAM metallopeptidase domain 10 |
Aliases | kuz; HsT18717; CD156c; a disintegrin and metalloproteinase domain 10; AD10; AD18; CDw156; a disintegrin and ...... |
Chromosomal Location | 15q2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of ADAM10 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | ADAM10 |
Name | ADAM metallopeptidase domain 10 |
Aliases | kuz; HsT18717; CD156c; a disintegrin and metalloproteinase domain 10; AD10; AD18; CDw156; a disintegrin and ...... |
Chromosomal Location | 15q2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ADAM10 in various data sets.
|
Points in the above scatter plot represent the mutation difference of ADAM10 in various data sets.
|
Summary | |
---|---|
Symbol | ADAM10 |
Name | ADAM metallopeptidase domain 10 |
Aliases | kuz; HsT18717; CD156c; a disintegrin and metalloproteinase domain 10; AD10; AD18; CDw156; a disintegrin and ...... |
Chromosomal Location | 15q2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ADAM10. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ADAM10 |
Name | ADAM metallopeptidase domain 10 |
Aliases | kuz; HsT18717; CD156c; a disintegrin and metalloproteinase domain 10; AD10; AD18; CDw156; a disintegrin and ...... |
Chromosomal Location | 15q2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ADAM10. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ADAM10. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ADAM10 |
Name | ADAM metallopeptidase domain 10 |
Aliases | kuz; HsT18717; CD156c; a disintegrin and metalloproteinase domain 10; AD10; AD18; CDw156; a disintegrin and ...... |
Chromosomal Location | 15q2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ADAM10. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ADAM10 |
Name | ADAM metallopeptidase domain 10 |
Aliases | kuz; HsT18717; CD156c; a disintegrin and metalloproteinase domain 10; AD10; AD18; CDw156; a disintegrin and ...... |
Chromosomal Location | 15q2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ADAM10 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ADAM10 |
Name | ADAM metallopeptidase domain 10 |
Aliases | kuz; HsT18717; CD156c; a disintegrin and metalloproteinase domain 10; AD10; AD18; CDw156; a disintegrin and ...... |
Chromosomal Location | 15q2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ADAM10 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ADAM10 |
Name | ADAM metallopeptidase domain 10 |
Aliases | kuz; HsT18717; CD156c; a disintegrin and metalloproteinase domain 10; AD10; AD18; CDw156; a disintegrin and ...... |
Chromosomal Location | 15q2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ADAM10 collected from DrugBank database. |
Details on drugs targeting ADAM10.
|