Summary | |
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Symbol | ADAM12 |
Name | ADAM metallopeptidase domain 12 |
Aliases | MCMPMltna; MLTN; meltrin alpha; a disintegrin and metalloproteinase domain 12 (meltrin alpha); ADAM12-OT1; C ...... |
Chromosomal Location | 10q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein.; SUBCELLULAR LOCATION: Isoform 2: Secreted.; SUBCELLULAR LOCATION: Isoform 3: Secreted ; SUBCELLULAR LOCATION: Isoform 4: Secreted |
Domain |
PF08516 ADAM cysteine-rich PF00200 Disintegrin PF01562 Reprolysin family propeptide PF01421 Reprolysin (M12B) family zinc metalloprotease |
Function |
Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity). |
Biological Process |
GO:0000768 syncytium formation by plasma membrane fusion GO:0006949 syncytium formation GO:0007520 myoblast fusion GO:0014902 myotube differentiation GO:0042692 muscle cell differentiation GO:0051146 striated muscle cell differentiation |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004222 metalloendopeptidase activity GO:0008237 metallopeptidase activity GO:0017124 SH3 domain binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR |
Summary | |
---|---|
Symbol | ADAM12 |
Name | ADAM metallopeptidase domain 12 |
Aliases | MCMPMltna; MLTN; meltrin alpha; a disintegrin and metalloproteinase domain 12 (meltrin alpha); ADAM12-OT1; C ...... |
Chromosomal Location | 10q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ADAM12 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ADAM12 |
Name | ADAM metallopeptidase domain 12 |
Aliases | MCMPMltna; MLTN; meltrin alpha; a disintegrin and metalloproteinase domain 12 (meltrin alpha); ADAM12-OT1; C ...... |
Chromosomal Location | 10q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ADAM12 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ADAM12 |
Name | ADAM metallopeptidase domain 12 |
Aliases | MCMPMltna; MLTN; meltrin alpha; a disintegrin and metalloproteinase domain 12 (meltrin alpha); ADAM12-OT1; C ...... |
Chromosomal Location | 10q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ADAM12 in various data sets.
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Points in the above scatter plot represent the mutation difference of ADAM12 in various data sets.
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Summary | |
---|---|
Symbol | ADAM12 |
Name | ADAM metallopeptidase domain 12 |
Aliases | MCMPMltna; MLTN; meltrin alpha; a disintegrin and metalloproteinase domain 12 (meltrin alpha); ADAM12-OT1; C ...... |
Chromosomal Location | 10q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ADAM12. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ADAM12 |
Name | ADAM metallopeptidase domain 12 |
Aliases | MCMPMltna; MLTN; meltrin alpha; a disintegrin and metalloproteinase domain 12 (meltrin alpha); ADAM12-OT1; C ...... |
Chromosomal Location | 10q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ADAM12. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ADAM12. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ADAM12 |
Name | ADAM metallopeptidase domain 12 |
Aliases | MCMPMltna; MLTN; meltrin alpha; a disintegrin and metalloproteinase domain 12 (meltrin alpha); ADAM12-OT1; C ...... |
Chromosomal Location | 10q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ADAM12. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ADAM12 |
Name | ADAM metallopeptidase domain 12 |
Aliases | MCMPMltna; MLTN; meltrin alpha; a disintegrin and metalloproteinase domain 12 (meltrin alpha); ADAM12-OT1; C ...... |
Chromosomal Location | 10q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ADAM12 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ADAM12 |
Name | ADAM metallopeptidase domain 12 |
Aliases | MCMPMltna; MLTN; meltrin alpha; a disintegrin and metalloproteinase domain 12 (meltrin alpha); ADAM12-OT1; C ...... |
Chromosomal Location | 10q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ADAM12 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ADAM12 |
Name | ADAM metallopeptidase domain 12 |
Aliases | MCMPMltna; MLTN; meltrin alpha; a disintegrin and metalloproteinase domain 12 (meltrin alpha); ADAM12-OT1; C ...... |
Chromosomal Location | 10q26 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ADAM12 collected from DrugBank database. |
There is no record. |