Summary | |
---|---|
Symbol | ADAM2 |
Name | ADAM metallopeptidase domain 2 |
Aliases | PH-30b; PH30; CT15; cancer/testis antigen 15; FTNB; fertilin beta; CRYN1; CRYN2; PH30-beta; fertilin subunit ...... |
Chromosomal Location | 8p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Domain |
PF08516 ADAM cysteine-rich PF00200 Disintegrin PF01562 Reprolysin family propeptide PF01421 Reprolysin (M12B) family zinc metalloprotease |
Function |
Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein. |
Biological Process |
GO:0007338 single fertilization GO:0007339 binding of sperm to zona pellucida GO:0007342 fusion of sperm to egg plasma membrane GO:0007611 learning or memory GO:0007612 learning GO:0007632 visual behavior GO:0008037 cell recognition GO:0008306 associative learning GO:0008542 visual learning GO:0009314 response to radiation GO:0009416 response to light stimulus GO:0009566 fertilization GO:0009988 cell-cell recognition GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030534 adult behavior GO:0035036 sperm-egg recognition GO:0044708 single-organism behavior GO:0044801 single-organism membrane fusion GO:0045026 plasma membrane fusion GO:0050890 cognition GO:0061025 membrane fusion |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004222 metalloendopeptidase activity GO:0005178 integrin binding GO:0008237 metallopeptidase activity GO:0050839 cell adhesion molecule binding |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-1187000: Fertilization R-HSA-1300644: Interaction With The Zona Pellucida R-HSA-1474165: Reproduction |
Summary | |
---|---|
Symbol | ADAM2 |
Name | ADAM metallopeptidase domain 2 |
Aliases | PH-30b; PH30; CT15; cancer/testis antigen 15; FTNB; fertilin beta; CRYN1; CRYN2; PH30-beta; fertilin subunit ...... |
Chromosomal Location | 8p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ADAM2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ADAM2 |
Name | ADAM metallopeptidase domain 2 |
Aliases | PH-30b; PH30; CT15; cancer/testis antigen 15; FTNB; fertilin beta; CRYN1; CRYN2; PH30-beta; fertilin subunit ...... |
Chromosomal Location | 8p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of ADAM2 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | ADAM2 |
Name | ADAM metallopeptidase domain 2 |
Aliases | PH-30b; PH30; CT15; cancer/testis antigen 15; FTNB; fertilin beta; CRYN1; CRYN2; PH30-beta; fertilin subunit ...... |
Chromosomal Location | 8p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ADAM2 in various data sets.
|
Points in the above scatter plot represent the mutation difference of ADAM2 in various data sets.
|
Summary | |
---|---|
Symbol | ADAM2 |
Name | ADAM metallopeptidase domain 2 |
Aliases | PH-30b; PH30; CT15; cancer/testis antigen 15; FTNB; fertilin beta; CRYN1; CRYN2; PH30-beta; fertilin subunit ...... |
Chromosomal Location | 8p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ADAM2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ADAM2 |
Name | ADAM metallopeptidase domain 2 |
Aliases | PH-30b; PH30; CT15; cancer/testis antigen 15; FTNB; fertilin beta; CRYN1; CRYN2; PH30-beta; fertilin subunit ...... |
Chromosomal Location | 8p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ADAM2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ADAM2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ADAM2 |
Name | ADAM metallopeptidase domain 2 |
Aliases | PH-30b; PH30; CT15; cancer/testis antigen 15; FTNB; fertilin beta; CRYN1; CRYN2; PH30-beta; fertilin subunit ...... |
Chromosomal Location | 8p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ADAM2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ADAM2 |
Name | ADAM metallopeptidase domain 2 |
Aliases | PH-30b; PH30; CT15; cancer/testis antigen 15; FTNB; fertilin beta; CRYN1; CRYN2; PH30-beta; fertilin subunit ...... |
Chromosomal Location | 8p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ADAM2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ADAM2 |
Name | ADAM metallopeptidase domain 2 |
Aliases | PH-30b; PH30; CT15; cancer/testis antigen 15; FTNB; fertilin beta; CRYN1; CRYN2; PH30-beta; fertilin subunit ...... |
Chromosomal Location | 8p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ADAM2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ADAM2 |
Name | ADAM metallopeptidase domain 2 |
Aliases | PH-30b; PH30; CT15; cancer/testis antigen 15; FTNB; fertilin beta; CRYN1; CRYN2; PH30-beta; fertilin subunit ...... |
Chromosomal Location | 8p11.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ADAM2 collected from DrugBank database. |
There is no record. |