Summary | |
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Symbol | ADAMTS12 |
Name | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
Aliases | a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; PRO4389; ADAM ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted, extracellular space, extracellular matrix |
Domain |
PF05986 ADAM-TS Spacer 1 PF01562 Reprolysin family propeptide PF01421 Reprolysin (M12B) family zinc metalloprotease PF00090 Thrombospondin type 1 domain |
Function |
Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. |
Biological Process |
GO:0001501 skeletal system development GO:0002062 chondrocyte differentiation GO:0003158 endothelium development GO:0003159 morphogenesis of an endothelium GO:0006029 proteoglycan metabolic process GO:0006516 glycoprotein catabolic process GO:0007160 cell-matrix adhesion GO:0009100 glycoprotein metabolic process GO:0030167 proteoglycan catabolic process GO:0031589 cell-substrate adhesion GO:0032330 regulation of chondrocyte differentiation GO:0032331 negative regulation of chondrocyte differentiation GO:0034612 response to tumor necrosis factor GO:0035239 tube morphogenesis GO:0035728 response to hepatocyte growth factor GO:0035729 cellular response to hepatocyte growth factor stimulus GO:0035924 cellular response to vascular endothelial growth factor stimulus GO:0048012 hepatocyte growth factor receptor signaling pathway GO:0050727 regulation of inflammatory response GO:0051216 cartilage development GO:0060562 epithelial tube morphogenesis GO:0061035 regulation of cartilage development GO:0061037 negative regulation of cartilage development GO:0061154 endothelial tube morphogenesis GO:0061448 connective tissue development GO:0070555 response to interleukin-1 GO:0071347 cellular response to interleukin-1 GO:0071356 cellular response to tumor necrosis factor GO:0071772 response to BMP GO:0071773 cellular response to BMP stimulus GO:0090287 regulation of cellular response to growth factor stimulus GO:0090288 negative regulation of cellular response to growth factor stimulus GO:1901136 carbohydrate derivative catabolic process GO:1901509 regulation of endothelial tube morphogenesis GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway GO:1902203 negative regulation of hepatocyte growth factor receptor signaling pathway GO:1902547 regulation of cellular response to vascular endothelial growth factor stimulus GO:1902548 negative regulation of cellular response to vascular endothelial growth factor stimulus GO:1905330 regulation of morphogenesis of an epithelium GO:2001112 regulation of cellular response to hepatocyte growth factor stimulus GO:2001113 negative regulation of cellular response to hepatocyte growth factor stimulus |
Molecular Function |
GO:0004175 endopeptidase activity GO:0004222 metalloendopeptidase activity GO:0008237 metallopeptidase activity |
Cellular Component |
GO:0005578 proteinaceous extracellular matrix |
KEGG | - |
Reactome |
R-HSA-5083635: Defective B3GALTL causes Peters-plus syndrome (PpS) R-HSA-1643685: Disease R-HSA-3906995: Diseases associated with O-glycosylation of proteins R-HSA-3781865: Diseases of glycosylation R-HSA-392499: Metabolism of proteins R-HSA-5173214: O-glycosylation of TSR domain-containing proteins R-HSA-5173105: O-linked glycosylation R-HSA-597592: Post-translational protein modification |
Summary | |
---|---|
Symbol | ADAMTS12 |
Name | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
Aliases | a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; PRO4389; ADAM ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ADAMTS12 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ADAMTS12 |
Name | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
Aliases | a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; PRO4389; ADAM ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ADAMTS12 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ADAMTS12 |
Name | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
Aliases | a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; PRO4389; ADAM ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ADAMTS12 in various data sets.
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Points in the above scatter plot represent the mutation difference of ADAMTS12 in various data sets.
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Summary | |
---|---|
Symbol | ADAMTS12 |
Name | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
Aliases | a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; PRO4389; ADAM ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ADAMTS12. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ADAMTS12 |
Name | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
Aliases | a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; PRO4389; ADAM ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ADAMTS12. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ADAMTS12. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ADAMTS12 |
Name | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
Aliases | a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; PRO4389; ADAM ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ADAMTS12. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ADAMTS12 |
Name | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
Aliases | a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; PRO4389; ADAM ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ADAMTS12 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ADAMTS12 |
Name | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
Aliases | a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; PRO4389; ADAM ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ADAMTS12 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ADAMTS12 |
Name | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
Aliases | a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 12; PRO4389; ADAM ...... |
Chromosomal Location | 5q35 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ADAMTS12 collected from DrugBank database. |
There is no record. |