Summary | |
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Symbol | ADCY5 |
Name | adenylate cyclase 5 |
Aliases | AC5; FDFM; ATP pyrophosphate-lyase 5; adenylate cyclase type V; adenylyl cyclase 5; Adenylate cyclase type 5 |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein. Cell projection, cilium |
Domain |
PF16214 Adenylyl cyclase N-terminal extracellular and transmembrane region PF06327 Domain of Unknown Function (DUF1053) PF00211 Adenylate and Guanylate cyclase catalytic domain |
Function |
Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling (PubMed:15385642, PubMed:26206488, PubMed:24700542). Mediates signaling downstream of ADRB1 (PubMed:24700542). Regulates the increase of free cytosolic Ca(2+) in response to increased blood glucose levels and contributes to the regulation of Ca(2+)-dependent insulin secretion (PubMed:24740569). |
Biological Process |
GO:0001678 cellular glucose homeostasis GO:0001973 adenosine receptor signaling pathway GO:0002790 peptide secretion GO:0002791 regulation of peptide secretion GO:0003014 renal system process GO:0003091 renal water homeostasis GO:0006140 regulation of nucleotide metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006171 cAMP biosynthetic process GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007190 activation of adenylate cyclase activity GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway GO:0007195 adenylate cyclase-inhibiting dopamine receptor signaling pathway GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007212 dopamine receptor signaling pathway GO:0007626 locomotory behavior GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009187 cyclic nucleotide metabolic process GO:0009190 cyclic nucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0009306 protein secretion GO:0009743 response to carbohydrate GO:0009746 response to hexose GO:0009749 response to glucose GO:0009914 hormone transport GO:0010817 regulation of hormone levels GO:0015833 peptide transport GO:0019932 second-messenger-mediated signaling GO:0019933 cAMP-mediated signaling GO:0019935 cyclic-nucleotide-mediated signaling GO:0023061 signal release GO:0030072 peptide hormone secretion GO:0030073 insulin secretion GO:0030104 water homeostasis GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030801 positive regulation of cyclic nucleotide metabolic process GO:0030802 regulation of cyclic nucleotide biosynthetic process GO:0030804 positive regulation of cyclic nucleotide biosynthetic process GO:0030808 regulation of nucleotide biosynthetic process GO:0030810 positive regulation of nucleotide biosynthetic process GO:0030814 regulation of cAMP metabolic process GO:0030816 positive regulation of cAMP metabolic process GO:0030817 regulation of cAMP biosynthetic process GO:0030819 positive regulation of cAMP biosynthetic process GO:0031279 regulation of cyclase activity GO:0031281 positive regulation of cyclase activity GO:0032147 activation of protein kinase activity GO:0032844 regulation of homeostatic process GO:0033500 carbohydrate homeostasis GO:0033674 positive regulation of kinase activity GO:0033762 response to glucagon GO:0034199 activation of protein kinase A activity GO:0034284 response to monosaccharide GO:0035587 purinergic receptor signaling pathway GO:0035588 G-protein coupled purinergic receptor signaling pathway GO:0035773 insulin secretion involved in cellular response to glucose stimulus GO:0042593 glucose homeostasis GO:0042886 amide transport GO:0043434 response to peptide hormone GO:0045761 regulation of adenylate cyclase activity GO:0045762 positive regulation of adenylate cyclase activity GO:0045860 positive regulation of protein kinase activity GO:0045981 positive regulation of nucleotide metabolic process GO:0046058 cAMP metabolic process GO:0046390 ribose phosphate biosynthetic process GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0048871 multicellular organismal homeostasis GO:0050708 regulation of protein secretion GO:0050796 regulation of insulin secretion GO:0050878 regulation of body fluid levels GO:0050885 neuromuscular process controlling balance GO:0050891 multicellular organismal water homeostasis GO:0050905 neuromuscular process GO:0051339 regulation of lyase activity GO:0051349 positive regulation of lyase activity GO:0051480 regulation of cytosolic calcium ion concentration GO:0052652 cyclic purine nucleotide metabolic process GO:0055074 calcium ion homeostasis GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus GO:0071322 cellular response to carbohydrate stimulus GO:0071326 cellular response to monosaccharide stimulus GO:0071331 cellular response to hexose stimulus GO:0071333 cellular response to glucose stimulus GO:0071375 cellular response to peptide hormone stimulus GO:0071377 cellular response to glucagon stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072522 purine-containing compound biosynthetic process GO:0090087 regulation of peptide transport GO:0090276 regulation of peptide hormone secretion GO:1900371 regulation of purine nucleotide biosynthetic process GO:1900373 positive regulation of purine nucleotide biosynthetic process GO:1900542 regulation of purine nucleotide metabolic process GO:1900544 positive regulation of purine nucleotide metabolic process GO:1901293 nucleoside phosphate biosynthetic process GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1901654 response to ketone GO:1901655 cellular response to ketone GO:1904321 response to forskolin GO:1904322 cellular response to forskolin |
Molecular Function |
GO:0004016 adenylate cyclase activity GO:0008179 adenylate cyclase binding GO:0009975 cyclase activity GO:0016829 lyase activity GO:0016849 phosphorus-oxygen lyase activity GO:0046982 protein heterodimerization activity GO:0097110 scaffold protein binding |
Cellular Component |
GO:0005929 cilium GO:0072372 primary cilium |
KEGG |
hsa04015 Rap1 signaling pathway hsa04022 cGMP-PKG signaling pathway hsa04024 cAMP signaling pathway hsa04062 Chemokine signaling pathway hsa04114 Oocyte meiosis hsa04261 Adrenergic signaling in cardiomyocytes hsa04270 Vascular smooth muscle contraction hsa04540 Gap junction hsa04611 Platelet activation hsa04713 Circadian entrainment hsa04723 Retrograde endocannabinoid signaling hsa04724 Glutamatergic synapse hsa04725 Cholinergic synapse hsa04726 Serotonergic synapse hsa04727 GABAergic synapse hsa04728 Dopaminergic synapse hsa04750 Inflammatory mediator regulation of TRP channels hsa04911 Insulin secretion hsa04912 GnRH signaling pathway hsa04913 Ovarian steroidogenesis hsa04914 Progesterone-mediated oocyte maturation hsa04915 Estrogen signaling pathway hsa04916 Melanogenesis hsa04918 Thyroid hormone synthesis hsa04921 Oxytocin signaling pathway hsa04970 Salivary secretion hsa04971 Gastric acid secretion hsa04972 Pancreatic secretion hsa04976 Bile secretion hsa00230 Purine metabolism |
Reactome |
R-HSA-991365: Activation of GABAB receptors R-HSA-170660: Adenylate cyclase activating pathway R-HSA-170670: Adenylate cyclase inhibitory pathway R-HSA-400042: Adrenaline,noradrenaline inhibits insulin secretion R-HSA-445717: Aquaporin-mediated transport R-HSA-111996: Ca-dependent events R-HSA-111997: CaM pathway R-HSA-111933: Calmodulin induced events R-HSA-1489509: DAG and IP3 signaling R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-186763: Downstream signal transduction R-HSA-212718: EGFR interacts with phospholipase C-gamma R-HSA-418594: G alpha (i) signalling events R-HSA-418555: G alpha (s) signalling events R-HSA-418597: G alpha (z) signalling events R-HSA-112040: G-protein mediated events R-HSA-977444: GABA B receptor activation R-HSA-977443: GABA receptor activation R-HSA-388396: GPCR downstream signaling R-HSA-163359: Glucagon signaling in metabolic regulation R-HSA-381676: Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-5610787: Hedgehog 'off' state R-HSA-168256: Immune System R-HSA-997269: Inhibition of adenylate cyclase pathway R-HSA-168249: Innate Immune System R-HSA-163685: Integration of energy metabolism R-HSA-1430728: Metabolism R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-112316: Neuronal System R-HSA-112314: Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell R-HSA-111885: Opioid Signalling R-HSA-163615: PKA activation R-HSA-164378: PKA activation in glucagon signalling R-HSA-111931: PKA-mediated phosphorylation of CREB R-HSA-112043: PLC beta mediated events R-HSA-167021: PLC-gamma1 signalling R-HSA-422356: Regulation of insulin secretion R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-372790: Signaling by GPCR R-HSA-5358351: Signaling by Hedgehog R-HSA-186797: Signaling by PDGF R-HSA-166520: Signalling by NGF R-HSA-382551: Transmembrane transport of small molecules R-HSA-112315: Transmission across Chemical Synapses R-HSA-432040: Vasopressin regulates renal water homeostasis via Aquaporins |
Summary | |
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Symbol | ADCY5 |
Name | adenylate cyclase 5 |
Aliases | AC5; FDFM; ATP pyrophosphate-lyase 5; adenylate cyclase type V; adenylyl cyclase 5; Adenylate cyclase type 5 |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ADCY5 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | ADCY5 |
Name | adenylate cyclase 5 |
Aliases | AC5; FDFM; ATP pyrophosphate-lyase 5; adenylate cyclase type V; adenylyl cyclase 5; Adenylate cyclase type 5 |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ADCY5 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ADCY5 |
Name | adenylate cyclase 5 |
Aliases | AC5; FDFM; ATP pyrophosphate-lyase 5; adenylate cyclase type V; adenylyl cyclase 5; Adenylate cyclase type 5 |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ADCY5 in various data sets.
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Points in the above scatter plot represent the mutation difference of ADCY5 in various data sets.
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Summary | |
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Symbol | ADCY5 |
Name | adenylate cyclase 5 |
Aliases | AC5; FDFM; ATP pyrophosphate-lyase 5; adenylate cyclase type V; adenylyl cyclase 5; Adenylate cyclase type 5 |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ADCY5. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ADCY5 |
Name | adenylate cyclase 5 |
Aliases | AC5; FDFM; ATP pyrophosphate-lyase 5; adenylate cyclase type V; adenylyl cyclase 5; Adenylate cyclase type 5 |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ADCY5. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ADCY5. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ADCY5 |
Name | adenylate cyclase 5 |
Aliases | AC5; FDFM; ATP pyrophosphate-lyase 5; adenylate cyclase type V; adenylyl cyclase 5; Adenylate cyclase type 5 |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ADCY5. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ADCY5 |
Name | adenylate cyclase 5 |
Aliases | AC5; FDFM; ATP pyrophosphate-lyase 5; adenylate cyclase type V; adenylyl cyclase 5; Adenylate cyclase type 5 |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ADCY5 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ADCY5 |
Name | adenylate cyclase 5 |
Aliases | AC5; FDFM; ATP pyrophosphate-lyase 5; adenylate cyclase type V; adenylyl cyclase 5; Adenylate cyclase type 5 |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ADCY5 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ADCY5 |
Name | adenylate cyclase 5 |
Aliases | AC5; FDFM; ATP pyrophosphate-lyase 5; adenylate cyclase type V; adenylyl cyclase 5; Adenylate cyclase type 5 |
Chromosomal Location | 3q21.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ADCY5 collected from DrugBank database. |
Details on drugs targeting ADCY5.
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