Summary | |
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Symbol | ADCYAP1R1 |
Name | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I |
Aliases | PACAPR; PAC1R; PACAP receptor 1; PACAPRI; PACAP type I receptor; PACAP-R1; pituitary adenylate cyclase activ ...... |
Chromosomal Location | 7p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00002 7 transmembrane receptor (Secretin family) PF02793 Hormone receptor domain |
Function |
This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. |
Biological Process |
GO:0006066 alcohol metabolic process GO:0006109 regulation of carbohydrate metabolic process GO:0006140 regulation of nucleotide metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006171 cAMP biosynthetic process GO:0006816 calcium ion transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007202 activation of phospholipase C activity GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007283 spermatogenesis GO:0007548 sex differentiation GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009187 cyclic nucleotide metabolic process GO:0009190 cyclic nucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0010517 regulation of phospholipase activity GO:0010518 positive regulation of phospholipase activity GO:0010522 regulation of calcium ion transport into cytosol GO:0010524 positive regulation of calcium ion transport into cytosol GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010676 positive regulation of cellular carbohydrate metabolic process GO:0010863 positive regulation of phospholipase C activity GO:0010919 regulation of inositol phosphate biosynthetic process GO:0010959 regulation of metal ion transport GO:0016051 carbohydrate biosynthetic process GO:0019751 polyol metabolic process GO:0019932 second-messenger-mediated signaling GO:0019933 cAMP-mediated signaling GO:0019935 cyclic-nucleotide-mediated signaling GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030801 positive regulation of cyclic nucleotide metabolic process GO:0030802 regulation of cyclic nucleotide biosynthetic process GO:0030804 positive regulation of cyclic nucleotide biosynthetic process GO:0030808 regulation of nucleotide biosynthetic process GO:0030810 positive regulation of nucleotide biosynthetic process GO:0030814 regulation of cAMP metabolic process GO:0030816 positive regulation of cAMP metabolic process GO:0030817 regulation of cAMP biosynthetic process GO:0030819 positive regulation of cAMP biosynthetic process GO:0032355 response to estradiol GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0032958 inositol phosphate biosynthetic process GO:0033555 multicellular organismal response to stress GO:0042493 response to drug GO:0043255 regulation of carbohydrate biosynthetic process GO:0043270 positive regulation of ion transport GO:0043647 inositol phosphate metabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044283 small molecule biosynthetic process GO:0044723 single-organism carbohydrate metabolic process GO:0045137 development of primary sexual characteristics GO:0045471 response to ethanol GO:0045913 positive regulation of carbohydrate metabolic process GO:0045981 positive regulation of nucleotide metabolic process GO:0046058 cAMP metabolic process GO:0046165 alcohol biosynthetic process GO:0046173 polyol biosynthetic process GO:0046390 ribose phosphate biosynthetic process GO:0046545 development of primary female sexual characteristics GO:0046660 female sex differentiation GO:0048232 male gamete generation GO:0051480 regulation of cytosolic calcium ion concentration GO:0051924 regulation of calcium ion transport GO:0051928 positive regulation of calcium ion transport GO:0052652 cyclic purine nucleotide metabolic process GO:0055074 calcium ion homeostasis GO:0060191 regulation of lipase activity GO:0060193 positive regulation of lipase activity GO:0060401 cytosolic calcium ion transport GO:0060402 calcium ion transport into cytosol GO:0060732 positive regulation of inositol phosphate biosynthetic process GO:0070838 divalent metal ion transport GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0072522 purine-containing compound biosynthetic process GO:0097305 response to alcohol GO:1900274 regulation of phospholipase C activity GO:1900371 regulation of purine nucleotide biosynthetic process GO:1900373 positive regulation of purine nucleotide biosynthetic process GO:1900542 regulation of purine nucleotide metabolic process GO:1900544 positive regulation of purine nucleotide metabolic process GO:1901293 nucleoside phosphate biosynthetic process GO:1901615 organic hydroxy compound metabolic process GO:1901617 organic hydroxy compound biosynthetic process GO:1902930 regulation of alcohol biosynthetic process GO:1902932 positive regulation of alcohol biosynthetic process GO:2000021 regulation of ion homeostasis |
Molecular Function |
GO:0004999 vasoactive intestinal polypeptide receptor activity GO:0008179 adenylate cyclase binding GO:0030306 ADP-ribosylation factor binding GO:0031267 small GTPase binding GO:0033218 amide binding GO:0042277 peptide binding GO:0042923 neuropeptide binding GO:0051020 GTPase binding |
Cellular Component |
GO:0005791 rough endoplasmic reticulum GO:0005901 caveola GO:0005923 bicellular tight junction GO:0043235 receptor complex GO:0043296 apical junction complex GO:0044853 plasma membrane raft GO:0045121 membrane raft GO:0070160 occluding junction GO:0098589 membrane region GO:0098857 membrane microdomain |
KEGG |
hsa04024 cAMP signaling pathway hsa04080 Neuroactive ligand-receptor interaction hsa04713 Circadian entrainment hsa04911 Insulin secretion |
Reactome |
R-HSA-187015: Activation of TRKA receptors R-HSA-373080: Class B/2 (Secretin family receptors) R-HSA-418555: G alpha (s) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-420092: Glucagon-type ligand receptors R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-187024: NGF-independant TRKA activation R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-166520: Signalling by NGF |
Summary | |
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Symbol | ADCYAP1R1 |
Name | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I |
Aliases | PACAPR; PAC1R; PACAP receptor 1; PACAPRI; PACAP type I receptor; PACAP-R1; pituitary adenylate cyclase activ ...... |
Chromosomal Location | 7p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ADCYAP1R1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ADCYAP1R1 |
Name | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I |
Aliases | PACAPR; PAC1R; PACAP receptor 1; PACAPRI; PACAP type I receptor; PACAP-R1; pituitary adenylate cyclase activ ...... |
Chromosomal Location | 7p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ADCYAP1R1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ADCYAP1R1 |
Name | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I |
Aliases | PACAPR; PAC1R; PACAP receptor 1; PACAPRI; PACAP type I receptor; PACAP-R1; pituitary adenylate cyclase activ ...... |
Chromosomal Location | 7p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ADCYAP1R1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ADCYAP1R1 in various data sets.
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Summary | |
---|---|
Symbol | ADCYAP1R1 |
Name | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I |
Aliases | PACAPR; PAC1R; PACAP receptor 1; PACAPRI; PACAP type I receptor; PACAP-R1; pituitary adenylate cyclase activ ...... |
Chromosomal Location | 7p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ADCYAP1R1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ADCYAP1R1 |
Name | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I |
Aliases | PACAPR; PAC1R; PACAP receptor 1; PACAPRI; PACAP type I receptor; PACAP-R1; pituitary adenylate cyclase activ ...... |
Chromosomal Location | 7p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ADCYAP1R1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ADCYAP1R1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ADCYAP1R1 |
Name | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I |
Aliases | PACAPR; PAC1R; PACAP receptor 1; PACAPRI; PACAP type I receptor; PACAP-R1; pituitary adenylate cyclase activ ...... |
Chromosomal Location | 7p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ADCYAP1R1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ADCYAP1R1 |
Name | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I |
Aliases | PACAPR; PAC1R; PACAP receptor 1; PACAPRI; PACAP type I receptor; PACAP-R1; pituitary adenylate cyclase activ ...... |
Chromosomal Location | 7p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ADCYAP1R1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ADCYAP1R1 |
Name | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I |
Aliases | PACAPR; PAC1R; PACAP receptor 1; PACAPRI; PACAP type I receptor; PACAP-R1; pituitary adenylate cyclase activ ...... |
Chromosomal Location | 7p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ADCYAP1R1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ADCYAP1R1 |
Name | adenylate cyclase activating polypeptide 1 (pituitary) receptor type I |
Aliases | PACAPR; PAC1R; PACAP receptor 1; PACAPRI; PACAP type I receptor; PACAP-R1; pituitary adenylate cyclase activ ...... |
Chromosomal Location | 7p14.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ADCYAP1R1 collected from DrugBank database. |
There is no record. |