Summary | |
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Symbol | ADGRV1 |
Name | adhesion G protein-coupled receptor V1 |
Aliases | DKFZp761P0710; KIAA0686; VLGR1; USH2C; MASS1; GPR98; monogenic, audiogenic seizure susceptibility 1 homolog ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00002 7 transmembrane receptor (Secretin family) PF03160 Calx-beta domain PF03736 EPTP domain |
Function |
Receptor that may have an important role in the development of the central nervous system. |
Biological Process |
GO:0001894 tissue homeostasis GO:0001895 retina homeostasis GO:0007601 visual perception GO:0007605 sensory perception of sound GO:0045494 photoreceptor cell maintenance GO:0048496 maintenance of animal organ identity GO:0048871 multicellular organismal homeostasis GO:0050953 sensory perception of light stimulus GO:0050954 sensory perception of mechanical stimulus GO:0060249 anatomical structure homeostasis |
Molecular Function | - |
Cellular Component |
GO:0032420 stereocilium GO:0032421 stereocilium bundle GO:0043235 receptor complex GO:0098858 actin-based cell projection GO:0098862 cluster of actin-based cell projections |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | ADGRV1 |
Name | adhesion G protein-coupled receptor V1 |
Aliases | DKFZp761P0710; KIAA0686; VLGR1; USH2C; MASS1; GPR98; monogenic, audiogenic seizure susceptibility 1 homolog ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ADGRV1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ADGRV1 |
Name | adhesion G protein-coupled receptor V1 |
Aliases | DKFZp761P0710; KIAA0686; VLGR1; USH2C; MASS1; GPR98; monogenic, audiogenic seizure susceptibility 1 homolog ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ADGRV1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ADGRV1 |
Name | adhesion G protein-coupled receptor V1 |
Aliases | DKFZp761P0710; KIAA0686; VLGR1; USH2C; MASS1; GPR98; monogenic, audiogenic seizure susceptibility 1 homolog ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ADGRV1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ADGRV1 in various data sets.
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Summary | |
---|---|
Symbol | ADGRV1 |
Name | adhesion G protein-coupled receptor V1 |
Aliases | DKFZp761P0710; KIAA0686; VLGR1; USH2C; MASS1; GPR98; monogenic, audiogenic seizure susceptibility 1 homolog ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ADGRV1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ADGRV1 |
Name | adhesion G protein-coupled receptor V1 |
Aliases | DKFZp761P0710; KIAA0686; VLGR1; USH2C; MASS1; GPR98; monogenic, audiogenic seizure susceptibility 1 homolog ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ADGRV1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ADGRV1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ADGRV1 |
Name | adhesion G protein-coupled receptor V1 |
Aliases | DKFZp761P0710; KIAA0686; VLGR1; USH2C; MASS1; GPR98; monogenic, audiogenic seizure susceptibility 1 homolog ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ADGRV1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ADGRV1 |
Name | adhesion G protein-coupled receptor V1 |
Aliases | DKFZp761P0710; KIAA0686; VLGR1; USH2C; MASS1; GPR98; monogenic, audiogenic seizure susceptibility 1 homolog ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ADGRV1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ADGRV1 |
Name | adhesion G protein-coupled receptor V1 |
Aliases | DKFZp761P0710; KIAA0686; VLGR1; USH2C; MASS1; GPR98; monogenic, audiogenic seizure susceptibility 1 homolog ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ADGRV1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ADGRV1 |
Name | adhesion G protein-coupled receptor V1 |
Aliases | DKFZp761P0710; KIAA0686; VLGR1; USH2C; MASS1; GPR98; monogenic, audiogenic seizure susceptibility 1 homolog ...... |
Chromosomal Location | 5q13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ADGRV1 collected from DrugBank database. |
There is no record. |