TISIDB

Summary
Symbol	ADH1A
Name	alcohol dehydrogenase 1A (class I), alpha polypeptide
Aliases	ADH1; ADH, alpha subunit; alcohol dehydrogenase 1 (class I), alpha polypeptide; alcohol dehydrogenase subuni ......
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway

> Subcellular Location, Domain and Function [ TOP ]
Subcellular Location	Cytoplasm.
Domain	PF08240 Alcohol dehydrogenase GroES-like domain PF00107 Zinc-binding dehydrogenase
Function	-

> Gene Ontology [ TOP ]
Biological Process	GO:0006066 alcohol metabolic process GO:0006067 ethanol metabolic process GO:0006069 ethanol oxidation GO:0017144 drug metabolic process GO:0034308 primary alcohol metabolic process GO:1901615 organic hydroxy compound metabolic process
Molecular Function	GO:0004022 alcohol dehydrogenase (NAD) activity GO:0004024 alcohol dehydrogenase activity, zinc-dependent GO:0004745 retinol dehydrogenase activity GO:0016614 oxidoreductase activity, acting on CH-OH group of donors GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Cellular Component	-

> KEGG and Reactome Pathway [ TOP ]
KEGG	hsa00010 Glycolysis / Gluconeogenesis hsa00071 Fatty acid degradation hsa00350 Tyrosine metabolism hsa00830 Retinol metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450 hsa00982 Drug metabolism - cytochrome P450 hsa01100 Metabolic pathways
Reactome	R-HSA-2161541: Abacavir metabolism R-HSA-2161522: Abacavir transport and metabolism R-HSA-211859: Biological oxidations R-HSA-71384: Ethanol oxidation R-HSA-1430728: Metabolism R-HSA-211945: Phase 1 - Functionalization of compounds R-HSA-5365859: RA biosynthesis pathway R-HSA-162582: Signal Transduction R-HSA-5362517: Signaling by Retinoic Acid

Summary
Symbol	ADH1A
Name	alcohol dehydrogenase 1A (class I), alpha polypeptide
Aliases	ADH1; ADH, alpha subunit; alcohol dehydrogenase 1 (class I), alpha polypeptide; alcohol dehydrogenase subuni ......
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Literatures that report relations between ADH1A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.

> Text Mining [ TOP ]
There is no record.

Summary
Symbol	ADH1A
Name	alcohol dehydrogenase 1A (class I), alpha polypeptide
Aliases	ADH1; ADH, alpha subunit; alcohol dehydrogenase 1 (class I), alpha polypeptide; alcohol dehydrogenase subuni ......
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.

> High-throughput Screening

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Statistical results of ADH1A in screening data sets for detecting immune reponses.

PMID	Screening System	Cancer Type	Cell Line	Data Set	Statistical Results	Relation to immunity
29301958	CRISPR-Cas9	melanoma	B16F10	Pmel-1 T cell	NA/NS	NA/NS
29301958	CRISPR-Cas9	melanoma	B16F10	OT-1 T cell	NA/NS	NA/NS
28783722	CRISPR-Cas9	melanoma	Mel624	2CT-CRISPR	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX+Anti-PD1	NA/NS	NA/NS
28723893	CRISPR-Cas9	melanoma	B16	GVAX	NA/NS	NA/NS
25691366	RNAi	Breast cancer	MCF7	Luc-CTL assay	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Primary screen	NA/NS	NA/NS
24476824	shRNA	melanoma	B16	Secondary screen	NA/NS	NA/NS

Summary
Symbol	ADH1A
Name	alcohol dehydrogenase 1A (class I), alpha polypeptide
Aliases	ADH1; ADH, alpha subunit; alcohol dehydrogenase 1 (class I), alpha polypeptide; alcohol dehydrogenase subuni ......
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders

> Expression difference between responders and non-responders

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Points in the above scatter plot represent the expression difference of ADH1A in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	Log2 (Fold Change)	P value
1	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	14	12	0.905	0.205
2	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	6	5	-0.033	0.977
3	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	7	1.608	0.106
4	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	-0.892	0.365
5	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	-2.222	0.213
6	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0.773	0.687
7	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	26	23	-0.025	0.981
8	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	15	11	1.241	0.439
9	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	11	12	-1.722	0.273
10	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	4	8	0.26	0.884
11	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	2	0	0	1
12	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	2	8	1.518	0.505
13	29443960	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	68	230	-0.784	0.0215

> Mutation difference between responders and non-responders

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Points in the above scatter plot represent the mutation difference of ADH1A in various data sets.

No	PMID	Cancer type	Group	Drug	# Res	# NRes	% Mut/Res	% Mut/NRes	% Diff (R vs NR)	Pval
1	25765070	Non-small cell lung cancer (NSCLC)	all	Anti-PD-1 (pembrolizumab)	14	17	0	0	0	1
2	25765070	Non-small cell lung cancer (NSCLC)	smoking	Anti-PD-1 (pembrolizumab)	10	3	0	0	0	1
3	25765070	Non-small cell lung cancer (NSCLC)	non-smoking	Anti-PD-1 (pembrolizumab)	4	14	0	0	0	1
4	26359337	Melanoma	all	Anti-CTLA-4 (ipilimumab)	27	73	3.7	4.1	-0.4	1
5	26359337	Melanoma	BRAFi	Anti-CTLA-4 (ipilimumab)	0	14	0	0	0	1
6	26359337	Melanoma	non-BRAFi	Anti-CTLA-4 (ipilimumab)	27	59	3.7	5.1	-1.4	1
7	26997480	Melanoma	all	Anti-PD-1 (pembrolizumab and nivolumab)	21	17	19	5.9	13.1	0.355
8	26997480	Melanoma	MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	8	6	37.5	0	37.5	0.209
9	26997480	Melanoma	non-MAPKi	Anti-PD-1 (pembrolizumab and nivolumab)	13	11	7.7	9.1	-1.4	1
10	28552987	Urothelial cancer	all	Anti-PD-L1 (atezolizumab)	9	16	0	0	0	1
11	28552987	Urothelial cancer	smoking	Anti-PD-L1 (atezolizumab)	5	9	0	0	0	1
12	28552987	Urothelial cancer	non-smoking	Anti-PD-L1 (atezolizumab)	4	7	0	0	0	1
13	29033130	Melanoma	all	Anti-PD-1 (nivolumab)	38	27	7.9	7.4	0.5	1
14	29033130	Melanoma	NIV3-PROG	Anti-PD-1 (nivolumab)	22	13	4.5	7.7	-3.2	1
15	29033130	Melanoma	NIV3-NAIVE	Anti-PD-1 (nivolumab)	16	14	12.5	7.1	5.4	1
16	29301960	Clear cell renal cell carcinoma (ccRCC)	all	Anti-PD-1 (nivolumab)	11	13	0	0	0	1
17	29301960	Clear cell renal cell carcinoma (ccRCC)	VEGFRi	Anti-PD-1 (nivolumab)	6	1	0	0	0	1
18	29301960	Clear cell renal cell carcinoma (ccRCC)	non-VEGFRi	Anti-PD-1 (nivolumab)	5	12	0	0	0	1

Summary
Symbol	ADH1A
Name	alcohol dehydrogenase 1A (class I), alpha polypeptide
Aliases	ADH1; ADH, alpha subunit; alcohol dehydrogenase 1 (class I), alpha polypeptide; alcohol dehydrogenase subuni ......
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ADH1A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.

> Lymphocyte [ TOP ]

Summary
Symbol	ADH1A
Name	alcohol dehydrogenase 1A (class I), alpha polypeptide
Aliases	ADH1; ADH, alpha subunit; alcohol dehydrogenase 1 (class I), alpha polypeptide; alcohol dehydrogenase subuni ......
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ADH1A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ADH1A. > Immunoinhibitor > Immunostimulator > MHC molecule

> Immunoinhibitor [ TOP ]

> Immunostimulator [ TOP ]

> MHC molecule [ TOP ]

Summary
Symbol	ADH1A
Name	alcohol dehydrogenase 1A (class I), alpha polypeptide
Aliases	ADH1; ADH, alpha subunit; alcohol dehydrogenase 1 (class I), alpha polypeptide; alcohol dehydrogenase subuni ......
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ADH1A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor

> Chemokine [ TOP ]

> Receptor [ TOP ]

Summary
Symbol	ADH1A
Name	alcohol dehydrogenase 1A (class I), alpha polypeptide
Aliases	ADH1; ADH, alpha subunit; alcohol dehydrogenase 1 (class I), alpha polypeptide; alcohol dehydrogenase subuni ......
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Distribution of ADH1A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype

> Immune subtype [ TOP ]

> Molecular subtype [ TOP ]

Summary
Symbol	ADH1A
Name	alcohol dehydrogenase 1A (class I), alpha polypeptide
Aliases	ADH1; ADH, alpha subunit; alcohol dehydrogenase 1 (class I), alpha polypeptide; alcohol dehydrogenase subuni ......
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Associations between ADH1A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade

> Overall survival [ TOP ]

> Stage [ TOP ]

> Grade [ TOP ]

Summary
Symbol	ADH1A
Name	alcohol dehydrogenase 1A (class I), alpha polypeptide
Aliases	ADH1; ADH, alpha subunit; alcohol dehydrogenase 1 (class I), alpha polypeptide; alcohol dehydrogenase subuni ......
Chromosomal Location	4q23
External Links	HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content	Drugs targeting ADH1A collected from DrugBank database.

> Drugs from DrugBank database

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Details on drugs targeting ADH1A.

ID	Name	Drug Type	Targets	#Targets
DB00157	NADH	Small Molecule	AASS, ACADS, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH7, AKR1B1, AKR1C1 ......	144
DB01213	Fomepizole	Small Molecule	ADH1A, ADH1B, ADH1C, CAT	4
DB02721	4-Iodopyrazole	Small Molecule	ADH1A, ADH1B, ADH1C	3
DB04065	N-Cyclopentyl-N-Cyclobutylformamide	Small Molecule	ADH1A	1

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