Summary | |
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Symbol | ADIPOR1 |
Name | adiponectin receptor 1 |
Aliases | PAQR1; ACDCR1; CGI-45; CGI45; TESBP1A; progestin and adipoQ receptor family member I; Adiponectin receptor p ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Multi-pass membrane protein Note=Localized to the cell membrane and intracellular organelles. |
Domain |
PF03006 Haemolysin-III related |
Function |
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin (By similarity). |
Biological Process |
GO:0001558 regulation of cell growth GO:0001667 ameboidal-type cell migration GO:0001837 epithelial to mesenchymal transition GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006109 regulation of carbohydrate metabolic process GO:0006631 fatty acid metabolic process GO:0007259 JAK-STAT cascade GO:0008286 insulin receptor signaling pathway GO:0009755 hormone-mediated signaling pathway GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010633 negative regulation of epithelial cell migration GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010717 regulation of epithelial to mesenchymal transition GO:0010719 negative regulation of epithelial to mesenchymal transition GO:0010906 regulation of glucose metabolic process GO:0016049 cell growth GO:0019216 regulation of lipid metabolic process GO:0019318 hexose metabolic process GO:0019395 fatty acid oxidation GO:0030258 lipid modification GO:0030308 negative regulation of cell growth GO:0030336 negative regulation of cell migration GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0033210 leptin-mediated signaling pathway GO:0033211 adiponectin-activated signaling pathway GO:0033500 carbohydrate homeostasis GO:0034440 lipid oxidation GO:0038061 NIK/NF-kappaB signaling GO:0040013 negative regulation of locomotion GO:0042593 glucose homeostasis GO:0043434 response to peptide hormone GO:0044262 cellular carbohydrate metabolic process GO:0044320 cellular response to leptin stimulus GO:0044321 response to leptin GO:0044723 single-organism carbohydrate metabolic process GO:0045926 negative regulation of growth GO:0046425 regulation of JAK-STAT cascade GO:0046426 negative regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046626 regulation of insulin receptor signaling pathway GO:0046628 positive regulation of insulin receptor signaling pathway GO:0048762 mesenchymal cell differentiation GO:0051271 negative regulation of cellular component movement GO:0060485 mesenchyme development GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0090130 tissue migration GO:0090132 epithelium migration GO:0097696 STAT cascade GO:1900076 regulation of cellular response to insulin stimulus GO:1900078 positive regulation of cellular response to insulin stimulus GO:1901222 regulation of NIK/NF-kappaB signaling GO:1901223 negative regulation of NIK/NF-kappaB signaling GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1902532 negative regulation of intracellular signal transduction GO:1904892 regulation of STAT cascade GO:1904893 negative regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:2000146 negative regulation of cell motility |
Molecular Function |
GO:0016500 protein-hormone receptor activity GO:0042562 hormone binding GO:0046982 protein heterodimerization activity GO:0055100 adiponectin binding GO:0097003 adipokinetic hormone receptor activity |
Cellular Component | - |
KEGG |
hsa04152 AMPK signaling pathway hsa04920 Adipocytokine signaling pathway |
Reactome |
R-HSA-163680: AMPK inhibits chREBP transcriptional activation activity R-HSA-163685: Integration of energy metabolism R-HSA-1430728: Metabolism |
Summary | |
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Symbol | ADIPOR1 |
Name | adiponectin receptor 1 |
Aliases | PAQR1; ACDCR1; CGI-45; CGI45; TESBP1A; progestin and adipoQ receptor family member I; Adiponectin receptor p ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ADIPOR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ADIPOR1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ADIPOR1 |
Name | adiponectin receptor 1 |
Aliases | PAQR1; ACDCR1; CGI-45; CGI45; TESBP1A; progestin and adipoQ receptor family member I; Adiponectin receptor p ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ADIPOR1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ADIPOR1 |
Name | adiponectin receptor 1 |
Aliases | PAQR1; ACDCR1; CGI-45; CGI45; TESBP1A; progestin and adipoQ receptor family member I; Adiponectin receptor p ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ADIPOR1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ADIPOR1 in various data sets.
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Summary | |
---|---|
Symbol | ADIPOR1 |
Name | adiponectin receptor 1 |
Aliases | PAQR1; ACDCR1; CGI-45; CGI45; TESBP1A; progestin and adipoQ receptor family member I; Adiponectin receptor p ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ADIPOR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ADIPOR1 |
Name | adiponectin receptor 1 |
Aliases | PAQR1; ACDCR1; CGI-45; CGI45; TESBP1A; progestin and adipoQ receptor family member I; Adiponectin receptor p ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ADIPOR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ADIPOR1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ADIPOR1 |
Name | adiponectin receptor 1 |
Aliases | PAQR1; ACDCR1; CGI-45; CGI45; TESBP1A; progestin and adipoQ receptor family member I; Adiponectin receptor p ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ADIPOR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ADIPOR1 |
Name | adiponectin receptor 1 |
Aliases | PAQR1; ACDCR1; CGI-45; CGI45; TESBP1A; progestin and adipoQ receptor family member I; Adiponectin receptor p ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ADIPOR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ADIPOR1 |
Name | adiponectin receptor 1 |
Aliases | PAQR1; ACDCR1; CGI-45; CGI45; TESBP1A; progestin and adipoQ receptor family member I; Adiponectin receptor p ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ADIPOR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ADIPOR1 |
Name | adiponectin receptor 1 |
Aliases | PAQR1; ACDCR1; CGI-45; CGI45; TESBP1A; progestin and adipoQ receptor family member I; Adiponectin receptor p ...... |
Chromosomal Location | 1q32.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ADIPOR1 collected from DrugBank database. |
There is no record. |