Summary | |
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Symbol | ADNP |
Name | activity-dependent neuroprotector homeobox |
Aliases | KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ...... |
Chromosomal Location | 20q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF00046 Homeobox domain |
Function |
Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation. |
Biological Process |
GO:0001558 regulation of cell growth GO:0006140 regulation of nucleotide metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006182 cGMP biosynthetic process GO:0006471 protein ADP-ribosylation GO:0006486 protein glycosylation GO:0007409 axonogenesis GO:0007416 synapse assembly GO:0007611 learning or memory GO:0007613 memory GO:0007614 short-term memory GO:0008361 regulation of cell size GO:0009100 glycoprotein metabolic process GO:0009101 glycoprotein biosynthetic process GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009187 cyclic nucleotide metabolic process GO:0009190 cyclic nucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0009743 response to carbohydrate GO:0009991 response to extracellular stimulus GO:0010035 response to inorganic substance GO:0010559 regulation of glycoprotein biosynthetic process GO:0010720 positive regulation of cell development GO:0010769 regulation of cell morphogenesis involved in differentiation GO:0010770 positive regulation of cell morphogenesis involved in differentiation GO:0010835 regulation of protein ADP-ribosylation GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0016049 cell growth GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0022604 regulation of cell morphogenesis GO:0030307 positive regulation of cell growth GO:0030516 regulation of axon extension GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030801 positive regulation of cyclic nucleotide metabolic process GO:0030802 regulation of cyclic nucleotide biosynthetic process GO:0030804 positive regulation of cyclic nucleotide biosynthetic process GO:0030808 regulation of nucleotide biosynthetic process GO:0030810 positive regulation of nucleotide biosynthetic process GO:0030823 regulation of cGMP metabolic process GO:0030825 positive regulation of cGMP metabolic process GO:0030826 regulation of cGMP biosynthetic process GO:0030828 positive regulation of cGMP biosynthetic process GO:0031346 positive regulation of cell projection organization GO:0031668 cellular response to extracellular stimulus GO:0032091 negative regulation of protein binding GO:0032147 activation of protein kinase activity GO:0032535 regulation of cellular component size GO:0033483 gas homeostasis GO:0033484 nitric oxide homeostasis GO:0033674 positive regulation of kinase activity GO:0042698 ovulation cycle GO:0043393 regulation of protein binding GO:0043413 macromolecule glycosylation GO:0043523 regulation of neuron apoptotic process GO:0043524 negative regulation of neuron apoptotic process GO:0044089 positive regulation of cellular component biogenesis GO:0044708 single-organism behavior GO:0044849 estrous cycle GO:0045666 positive regulation of neuron differentiation GO:0045773 positive regulation of axon extension GO:0045860 positive regulation of protein kinase activity GO:0045927 positive regulation of growth GO:0045981 positive regulation of nucleotide metabolic process GO:0046068 cGMP metabolic process GO:0046390 ribose phosphate biosynthetic process GO:0048511 rhythmic process GO:0048588 developmental cell growth GO:0048638 regulation of developmental growth GO:0048639 positive regulation of developmental growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048675 axon extension GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050769 positive regulation of neurogenesis GO:0050770 regulation of axonogenesis GO:0050772 positive regulation of axonogenesis GO:0050803 regulation of synapse structure or activity GO:0050804 modulation of synaptic transmission GO:0050805 negative regulation of synaptic transmission GO:0050807 regulation of synapse organization GO:0050808 synapse organization GO:0050890 cognition GO:0051098 regulation of binding GO:0051100 negative regulation of binding GO:0051402 neuron apoptotic process GO:0051962 positive regulation of nervous system development GO:0051963 regulation of synapse assembly GO:0051965 positive regulation of synapse assembly GO:0052652 cyclic purine nucleotide metabolic process GO:0060049 regulation of protein glycosylation GO:0060560 developmental growth involved in morphogenesis GO:0061387 regulation of extent of cell growth GO:0061564 axon development GO:0070085 glycosylation GO:0070997 neuron death GO:0071496 cellular response to external stimulus GO:0072522 purine-containing compound biosynthetic process GO:0090066 regulation of anatomical structure size GO:1900371 regulation of purine nucleotide biosynthetic process GO:1900373 positive regulation of purine nucleotide biosynthetic process GO:1900542 regulation of purine nucleotide metabolic process GO:1900544 positive regulation of purine nucleotide metabolic process GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1901293 nucleoside phosphate biosynthetic process GO:1903018 regulation of glycoprotein metabolic process GO:1990138 neuron projection extension |
Molecular Function |
GO:0003682 chromatin binding GO:0005507 copper ion binding GO:0015631 tubulin binding GO:0033218 amide binding GO:0042277 peptide binding GO:0048487 beta-tubulin binding |
Cellular Component |
GO:0030424 axon GO:0030425 dendrite GO:0043025 neuronal cell body GO:0044297 cell body |
KEGG | - |
Reactome | - |
Summary | |
---|---|
Symbol | ADNP |
Name | activity-dependent neuroprotector homeobox |
Aliases | KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ...... |
Chromosomal Location | 20q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ADNP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ADNP |
Name | activity-dependent neuroprotector homeobox |
Aliases | KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ...... |
Chromosomal Location | 20q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ADNP in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ADNP |
Name | activity-dependent neuroprotector homeobox |
Aliases | KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ...... |
Chromosomal Location | 20q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ADNP in various data sets.
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Points in the above scatter plot represent the mutation difference of ADNP in various data sets.
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Summary | |
---|---|
Symbol | ADNP |
Name | activity-dependent neuroprotector homeobox |
Aliases | KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ...... |
Chromosomal Location | 20q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ADNP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ADNP |
Name | activity-dependent neuroprotector homeobox |
Aliases | KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ...... |
Chromosomal Location | 20q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ADNP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ADNP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ADNP |
Name | activity-dependent neuroprotector homeobox |
Aliases | KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ...... |
Chromosomal Location | 20q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ADNP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ADNP |
Name | activity-dependent neuroprotector homeobox |
Aliases | KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ...... |
Chromosomal Location | 20q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ADNP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ADNP |
Name | activity-dependent neuroprotector homeobox |
Aliases | KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ...... |
Chromosomal Location | 20q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ADNP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ADNP |
Name | activity-dependent neuroprotector homeobox |
Aliases | KIAA0784; ADNP1; ADNP homeobox 1; activity-dependent neuroprotector; HVDAS; MRD28; activity-dependent neurop ...... |
Chromosomal Location | 20q13.13 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ADNP collected from DrugBank database. |
There is no record. |