Summary | |
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Symbol | ADORA2A |
Name | adenosine A2a receptor |
Aliases | RDC8; A2aR; adenosine receptor subtype A2a; Adenosine receptor A2a |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. |
Biological Process |
GO:0001973 adenosine receptor signaling pathway GO:0003013 circulatory system process GO:0006140 regulation of nucleotide metabolic process GO:0006164 purine nucleotide biosynthetic process GO:0006171 cAMP biosynthetic process GO:0006909 phagocytosis GO:0006968 cellular defense response GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008015 blood circulation GO:0009150 purine ribonucleotide metabolic process GO:0009152 purine ribonucleotide biosynthetic process GO:0009165 nucleotide biosynthetic process GO:0009187 cyclic nucleotide metabolic process GO:0009190 cyclic nucleotide biosynthetic process GO:0009260 ribonucleotide biosynthetic process GO:0010578 regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway GO:0010579 positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway GO:0030799 regulation of cyclic nucleotide metabolic process GO:0030801 positive regulation of cyclic nucleotide metabolic process GO:0030802 regulation of cyclic nucleotide biosynthetic process GO:0030804 positive regulation of cyclic nucleotide biosynthetic process GO:0030808 regulation of nucleotide biosynthetic process GO:0030810 positive regulation of nucleotide biosynthetic process GO:0030814 regulation of cAMP metabolic process GO:0030816 positive regulation of cAMP metabolic process GO:0030817 regulation of cAMP biosynthetic process GO:0030819 positive regulation of cAMP biosynthetic process GO:0031279 regulation of cyclase activity GO:0031281 positive regulation of cyclase activity GO:0035587 purinergic receptor signaling pathway GO:0035588 G-protein coupled purinergic receptor signaling pathway GO:0045761 regulation of adenylate cyclase activity GO:0045762 positive regulation of adenylate cyclase activity GO:0045981 positive regulation of nucleotide metabolic process GO:0046058 cAMP metabolic process GO:0046390 ribose phosphate biosynthetic process GO:0050817 coagulation GO:0050878 regulation of body fluid levels GO:0051339 regulation of lyase activity GO:0051349 positive regulation of lyase activity GO:0052652 cyclic purine nucleotide metabolic process GO:0072522 purine-containing compound biosynthetic process GO:1900371 regulation of purine nucleotide biosynthetic process GO:1900373 positive regulation of purine nucleotide biosynthetic process GO:1900542 regulation of purine nucleotide metabolic process GO:1900544 positive regulation of purine nucleotide metabolic process GO:1901293 nucleoside phosphate biosynthetic process |
Molecular Function |
GO:0001609 G-protein coupled adenosine receptor activity GO:0035586 purinergic receptor activity |
Cellular Component | - |
KEGG |
hsa04015 Rap1 signaling pathway hsa04020 Calcium signaling pathway hsa04024 cAMP signaling pathway hsa04080 Neuroactive ligand-receptor interaction hsa04270 Vascular smooth muscle contraction |
Reactome |
R-HSA-187015: Activation of TRKA receptors R-HSA-417973: Adenosine P1 receptors R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-418555: G alpha (s) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-392499: Metabolism of proteins R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-187024: NGF-independant TRKA activation R-HSA-418038: Nucleotide-like (purinergic) receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-166520: Signalling by NGF R-HSA-5683826: Surfactant metabolism |
Summary | |
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Symbol | ADORA2A |
Name | adenosine A2a receptor |
Aliases | RDC8; A2aR; adenosine receptor subtype A2a; Adenosine receptor A2a |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ADORA2A and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ADORA2A and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ADORA2A |
Name | adenosine A2a receptor |
Aliases | RDC8; A2aR; adenosine receptor subtype A2a; Adenosine receptor A2a |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ADORA2A in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ADORA2A |
Name | adenosine A2a receptor |
Aliases | RDC8; A2aR; adenosine receptor subtype A2a; Adenosine receptor A2a |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ADORA2A in various data sets.
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Points in the above scatter plot represent the mutation difference of ADORA2A in various data sets.
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Summary | |
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Symbol | ADORA2A |
Name | adenosine A2a receptor |
Aliases | RDC8; A2aR; adenosine receptor subtype A2a; Adenosine receptor A2a |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ADORA2A. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ADORA2A |
Name | adenosine A2a receptor |
Aliases | RDC8; A2aR; adenosine receptor subtype A2a; Adenosine receptor A2a |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ADORA2A. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ADORA2A. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ADORA2A |
Name | adenosine A2a receptor |
Aliases | RDC8; A2aR; adenosine receptor subtype A2a; Adenosine receptor A2a |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ADORA2A. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ADORA2A |
Name | adenosine A2a receptor |
Aliases | RDC8; A2aR; adenosine receptor subtype A2a; Adenosine receptor A2a |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ADORA2A expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ADORA2A |
Name | adenosine A2a receptor |
Aliases | RDC8; A2aR; adenosine receptor subtype A2a; Adenosine receptor A2a |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ADORA2A and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ADORA2A |
Name | adenosine A2a receptor |
Aliases | RDC8; A2aR; adenosine receptor subtype A2a; Adenosine receptor A2a |
Chromosomal Location | 22q11.23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ADORA2A collected from DrugBank database. |
Details on drugs targeting ADORA2A.
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