Summary | |
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Symbol | ADRM1 |
Name | adhesion regulating molecule 1 |
Aliases | Rpn13; ARM-1; 110 kDa cell membrane glycoprotein; M(r) 110,000 surface antigen; proteasome regulatory partic ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus |
Domain |
PF04683 Proteasome complex subunit Rpn13 ubiquitin receptor PF16550 UCH-binding domain |
Function |
Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Within the complex, functions as a proteasomal ubiquitin receptor. Engages and activates 19S-associated deubiquitinases UCHL5 and PSMD14 during protein degradation. UCHL5 reversibly associate with the 19S regulatory particle whereas PSMD14 is an intrinsic subunit of the proteasome lid subcomplex. |
Biological Process |
GO:0006354 DNA-templated transcription, elongation GO:0006368 transcription elongation from RNA polymerase II promoter GO:0010950 positive regulation of endopeptidase activity GO:0010952 positive regulation of peptidase activity GO:0043248 proteasome assembly GO:0045862 positive regulation of proteolysis GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity |
Molecular Function |
GO:0002020 protease binding GO:0008047 enzyme activator activity GO:0016504 peptidase activator activity GO:0061133 endopeptidase activator activity GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity GO:0070628 proteasome binding |
Cellular Component |
GO:0000502 proteasome complex GO:1905368 peptidase complex GO:1905369 endopeptidase complex |
KEGG |
hsa03050 Proteasome |
Reactome |
R-HSA-5688426: Deubiquitination R-HSA-392499: Metabolism of proteins R-HSA-597592: Post-translational protein modification R-HSA-5689603: UCH proteinases R-HSA-5689880: Ub-specific processing proteases |
Summary | |
---|---|
Symbol | ADRM1 |
Name | adhesion regulating molecule 1 |
Aliases | Rpn13; ARM-1; 110 kDa cell membrane glycoprotein; M(r) 110,000 surface antigen; proteasome regulatory partic ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ADRM1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ADRM1 |
Name | adhesion regulating molecule 1 |
Aliases | Rpn13; ARM-1; 110 kDa cell membrane glycoprotein; M(r) 110,000 surface antigen; proteasome regulatory partic ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ADRM1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ADRM1 |
Name | adhesion regulating molecule 1 |
Aliases | Rpn13; ARM-1; 110 kDa cell membrane glycoprotein; M(r) 110,000 surface antigen; proteasome regulatory partic ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ADRM1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ADRM1 in various data sets.
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Summary | |
---|---|
Symbol | ADRM1 |
Name | adhesion regulating molecule 1 |
Aliases | Rpn13; ARM-1; 110 kDa cell membrane glycoprotein; M(r) 110,000 surface antigen; proteasome regulatory partic ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ADRM1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ADRM1 |
Name | adhesion regulating molecule 1 |
Aliases | Rpn13; ARM-1; 110 kDa cell membrane glycoprotein; M(r) 110,000 surface antigen; proteasome regulatory partic ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ADRM1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ADRM1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ADRM1 |
Name | adhesion regulating molecule 1 |
Aliases | Rpn13; ARM-1; 110 kDa cell membrane glycoprotein; M(r) 110,000 surface antigen; proteasome regulatory partic ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ADRM1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ADRM1 |
Name | adhesion regulating molecule 1 |
Aliases | Rpn13; ARM-1; 110 kDa cell membrane glycoprotein; M(r) 110,000 surface antigen; proteasome regulatory partic ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ADRM1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ADRM1 |
Name | adhesion regulating molecule 1 |
Aliases | Rpn13; ARM-1; 110 kDa cell membrane glycoprotein; M(r) 110,000 surface antigen; proteasome regulatory partic ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ADRM1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ADRM1 |
Name | adhesion regulating molecule 1 |
Aliases | Rpn13; ARM-1; 110 kDa cell membrane glycoprotein; M(r) 110,000 surface antigen; proteasome regulatory partic ...... |
Chromosomal Location | 20q13.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ADRM1 collected from DrugBank database. |
There is no record. |