Summary | |
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Symbol | AGPAT4 |
Name | 1-acylglycerol-3-phosphate O-acyltransferase 4 |
Aliases | LPAAT-delta; dJ473J16.2; lysophosphatidic acid acyltransferase, delta; 1-acylglycerol-3-phosphate O-acyltran ...... |
Chromosomal Location | 6q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Multi-pass membrane protein |
Domain |
PF16076 Acyltransferase C-terminus PF01553 Acyltransferase |
Function |
Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. |
Biological Process |
GO:0006638 neutral lipid metabolic process GO:0006639 acylglycerol metabolic process GO:0006641 triglyceride metabolic process GO:0006644 phospholipid metabolic process GO:0006650 glycerophospholipid metabolic process GO:0006654 phosphatidic acid biosynthetic process GO:0008654 phospholipid biosynthetic process GO:0016024 CDP-diacylglycerol biosynthetic process GO:0019432 triglyceride biosynthetic process GO:0045017 glycerolipid biosynthetic process GO:0046341 CDP-diacylglycerol metabolic process GO:0046460 neutral lipid biosynthetic process GO:0046463 acylglycerol biosynthetic process GO:0046473 phosphatidic acid metabolic process GO:0046474 glycerophospholipid biosynthetic process GO:0046486 glycerolipid metabolic process |
Molecular Function |
GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity GO:0008374 O-acyltransferase activity GO:0016411 acylglycerol O-acyltransferase activity GO:0016746 transferase activity, transferring acyl groups GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups GO:0042171 lysophosphatidic acid acyltransferase activity GO:0071617 lysophospholipid acyltransferase activity |
Cellular Component | - |
KEGG |
hsa00561 Glycerolipid metabolism hsa00564 Glycerophospholipid metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-1483206: Glycerophospholipid biosynthesis R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1483257: Phospholipid metabolism R-HSA-1483166: Synthesis of PA R-HSA-75109: Triglyceride Biosynthesis |
Summary | |
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Symbol | AGPAT4 |
Name | 1-acylglycerol-3-phosphate O-acyltransferase 4 |
Aliases | LPAAT-delta; dJ473J16.2; lysophosphatidic acid acyltransferase, delta; 1-acylglycerol-3-phosphate O-acyltran ...... |
Chromosomal Location | 6q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between AGPAT4 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | AGPAT4 |
Name | 1-acylglycerol-3-phosphate O-acyltransferase 4 |
Aliases | LPAAT-delta; dJ473J16.2; lysophosphatidic acid acyltransferase, delta; 1-acylglycerol-3-phosphate O-acyltran ...... |
Chromosomal Location | 6q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of AGPAT4 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | AGPAT4 |
Name | 1-acylglycerol-3-phosphate O-acyltransferase 4 |
Aliases | LPAAT-delta; dJ473J16.2; lysophosphatidic acid acyltransferase, delta; 1-acylglycerol-3-phosphate O-acyltran ...... |
Chromosomal Location | 6q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of AGPAT4 in various data sets.
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Points in the above scatter plot represent the mutation difference of AGPAT4 in various data sets.
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Summary | |
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Symbol | AGPAT4 |
Name | 1-acylglycerol-3-phosphate O-acyltransferase 4 |
Aliases | LPAAT-delta; dJ473J16.2; lysophosphatidic acid acyltransferase, delta; 1-acylglycerol-3-phosphate O-acyltran ...... |
Chromosomal Location | 6q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AGPAT4. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | AGPAT4 |
Name | 1-acylglycerol-3-phosphate O-acyltransferase 4 |
Aliases | LPAAT-delta; dJ473J16.2; lysophosphatidic acid acyltransferase, delta; 1-acylglycerol-3-phosphate O-acyltran ...... |
Chromosomal Location | 6q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AGPAT4. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AGPAT4. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | AGPAT4 |
Name | 1-acylglycerol-3-phosphate O-acyltransferase 4 |
Aliases | LPAAT-delta; dJ473J16.2; lysophosphatidic acid acyltransferase, delta; 1-acylglycerol-3-phosphate O-acyltran ...... |
Chromosomal Location | 6q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AGPAT4. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | AGPAT4 |
Name | 1-acylglycerol-3-phosphate O-acyltransferase 4 |
Aliases | LPAAT-delta; dJ473J16.2; lysophosphatidic acid acyltransferase, delta; 1-acylglycerol-3-phosphate O-acyltran ...... |
Chromosomal Location | 6q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of AGPAT4 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | AGPAT4 |
Name | 1-acylglycerol-3-phosphate O-acyltransferase 4 |
Aliases | LPAAT-delta; dJ473J16.2; lysophosphatidic acid acyltransferase, delta; 1-acylglycerol-3-phosphate O-acyltran ...... |
Chromosomal Location | 6q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between AGPAT4 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | AGPAT4 |
Name | 1-acylglycerol-3-phosphate O-acyltransferase 4 |
Aliases | LPAAT-delta; dJ473J16.2; lysophosphatidic acid acyltransferase, delta; 1-acylglycerol-3-phosphate O-acyltran ...... |
Chromosomal Location | 6q25.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting AGPAT4 collected from DrugBank database. |
There is no record. |