Summary | |
---|---|
Symbol | AGT |
Name | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
Aliases | SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ...... |
Chromosomal Location | 1q42.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Secreted. |
Domain |
PF00079 Serpin (serine protease inhibitor) |
Function |
Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.; FUNCTION: Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.; FUNCTION: Angiotensin-3: stimulates aldosterone release.; FUNCTION: Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets. |
Biological Process |
GO:0001525 angiogenesis GO:0001558 regulation of cell growth GO:0001655 urogenital system development GO:0001657 ureteric bud development GO:0001658 branching involved in ureteric bud morphogenesis GO:0001667 ameboidal-type cell migration GO:0001763 morphogenesis of a branching structure GO:0001819 positive regulation of cytokine production GO:0001822 kidney development GO:0001823 mesonephros development GO:0001974 blood vessel remodeling GO:0001976 neurological system process involved in regulation of systemic arterial blood pressure GO:0001990 regulation of systemic arterial blood pressure by hormone GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin GO:0002002 regulation of angiotensin levels in blood GO:0002003 angiotensin maturation GO:0002016 regulation of blood volume by renin-angiotensin GO:0002018 renin-angiotensin regulation of aldosterone production GO:0002019 regulation of renal output by angiotensin GO:0002027 regulation of heart rate GO:0002034 regulation of blood vessel size by renin-angiotensin GO:0002035 brain renin-angiotensin system GO:0003012 muscle system process GO:0003013 circulatory system process GO:0003014 renal system process GO:0003015 heart process GO:0003018 vascular process in circulatory system GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003051 angiotensin-mediated drinking behavior GO:0003071 renal system process involved in regulation of systemic arterial blood pressure GO:0003072 renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure GO:0003073 regulation of systemic arterial blood pressure GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin GO:0003298 physiological muscle hypertrophy GO:0003300 cardiac muscle hypertrophy GO:0003301 physiological cardiac muscle hypertrophy GO:0003330 regulation of extracellular matrix constituent secretion GO:0003331 positive regulation of extracellular matrix constituent secretion GO:0006606 protein import into nucleus GO:0006801 superoxide metabolic process GO:0006809 nitric oxide biosynthetic process GO:0006816 calcium ion transport GO:0006865 amino acid transport GO:0006869 lipid transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0006883 cellular sodium ion homeostasis GO:0006913 nucleocytoplasmic transport GO:0006936 muscle contraction GO:0006939 smooth muscle contraction GO:0007043 cell-cell junction assembly GO:0007173 epidermal growth factor receptor signaling pathway GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007202 activation of phospholipase C activity GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007259 JAK-STAT cascade GO:0007263 nitric oxide mediated signal transduction GO:0007507 heart development GO:0007565 female pregnancy GO:0007568 aging GO:0007588 excretion GO:0007631 feeding behavior GO:0008015 blood circulation GO:0008016 regulation of heart contraction GO:0008202 steroid metabolic process GO:0008217 regulation of blood pressure GO:0008643 carbohydrate transport GO:0008645 hexose transport GO:0009306 protein secretion GO:0009612 response to mechanical stimulus GO:0009914 hormone transport GO:0010466 negative regulation of peptidase activity GO:0010517 regulation of phospholipase activity GO:0010518 positive regulation of phospholipase activity GO:0010533 regulation of activation of Janus kinase activity GO:0010534 regulation of activation of JAK2 kinase activity GO:0010535 positive regulation of activation of JAK2 kinase activity GO:0010536 positive regulation of activation of Janus kinase activity GO:0010594 regulation of endothelial cell migration GO:0010595 positive regulation of endothelial cell migration GO:0010611 regulation of cardiac muscle hypertrophy GO:0010613 positive regulation of cardiac muscle hypertrophy GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0010657 muscle cell apoptotic process GO:0010658 striated muscle cell apoptotic process GO:0010659 cardiac muscle cell apoptotic process GO:0010660 regulation of muscle cell apoptotic process GO:0010661 positive regulation of muscle cell apoptotic process GO:0010662 regulation of striated muscle cell apoptotic process GO:0010663 positive regulation of striated muscle cell apoptotic process GO:0010665 regulation of cardiac muscle cell apoptotic process GO:0010666 positive regulation of cardiac muscle cell apoptotic process GO:0010742 macrophage derived foam cell differentiation GO:0010743 regulation of macrophage derived foam cell differentiation GO:0010744 positive regulation of macrophage derived foam cell differentiation GO:0010805 regulation of lysine import GO:0010817 regulation of hormone levels GO:0010827 regulation of glucose transport GO:0010828 positive regulation of glucose transport GO:0010863 positive regulation of phospholipase C activity GO:0010872 regulation of cholesterol esterification GO:0010873 positive regulation of cholesterol esterification GO:0010876 lipid localization GO:0010951 negative regulation of endopeptidase activity GO:0010958 regulation of amino acid import GO:0010959 regulation of metal ion transport GO:0010963 regulation of L-arginine import GO:0014061 regulation of norepinephrine secretion GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014706 striated muscle tissue development GO:0014742 positive regulation of muscle hypertrophy GO:0014743 regulation of muscle hypertrophy GO:0014812 muscle cell migration GO:0014820 tonic smooth muscle contraction GO:0014823 response to activity GO:0014824 artery smooth muscle contraction GO:0014829 vascular smooth muscle contraction GO:0014850 response to muscle activity GO:0014873 response to muscle activity involved in regulation of muscle adaptation GO:0014874 response to stimulus involved in regulation of muscle adaptation GO:0014896 muscle hypertrophy GO:0014897 striated muscle hypertrophy GO:0014909 smooth muscle cell migration GO:0014910 regulation of smooth muscle cell migration GO:0014911 positive regulation of smooth muscle cell migration GO:0015749 monosaccharide transport GO:0015758 glucose transport GO:0015837 amine transport GO:0015844 monoamine transport GO:0015849 organic acid transport GO:0015850 organic hydroxy compound transport GO:0015874 norepinephrine transport GO:0016049 cell growth GO:0016264 gap junction assembly GO:0016485 protein processing GO:0016486 peptide hormone processing GO:0016525 negative regulation of angiogenesis GO:0017038 protein import GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0019216 regulation of lipid metabolic process GO:0019218 regulation of steroid metabolic process GO:0019226 transmission of nerve impulse GO:0019229 regulation of vasoconstriction GO:0019932 second-messenger-mediated signaling GO:0023061 signal release GO:0030004 cellular monovalent inorganic cation homeostasis GO:0030198 extracellular matrix organization GO:0030258 lipid modification GO:0030308 negative regulation of cell growth GO:0030335 positive regulation of cell migration GO:0031098 stress-activated protein kinase signaling cascade GO:0031349 positive regulation of defense response GO:0031644 regulation of neurological system process GO:0032103 positive regulation of response to external stimulus GO:0032147 activation of protein kinase activity GO:0032368 regulation of lipid transport GO:0032844 regulation of homeostatic process GO:0032846 positive regulation of homeostatic process GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0032890 regulation of organic acid transport GO:0032892 positive regulation of organic acid transport GO:0032928 regulation of superoxide anion generation GO:0032930 positive regulation of superoxide anion generation GO:0033002 muscle cell proliferation GO:0033674 positive regulation of kinase activity GO:0033860 regulation of NAD(P)H oxidase activity GO:0033864 positive regulation of NAD(P)H oxidase activity GO:0034103 regulation of tissue remodeling GO:0034104 negative regulation of tissue remodeling GO:0034226 lysine import GO:0034329 cell junction assembly GO:0034330 cell junction organization GO:0034367 macromolecular complex remodeling GO:0034368 protein-lipid complex remodeling GO:0034369 plasma lipoprotein particle remodeling GO:0034374 low-density lipoprotein particle remodeling GO:0034433 steroid esterification GO:0034434 sterol esterification GO:0034435 cholesterol esterification GO:0034504 protein localization to nucleus GO:0035051 cardiocyte differentiation GO:0035150 regulation of tube size GO:0035239 tube morphogenesis GO:0035265 organ growth GO:0035411 catenin import into nucleus GO:0035637 multicellular organismal signaling GO:0035812 renal sodium excretion GO:0035813 regulation of renal sodium excretion GO:0035815 positive regulation of renal sodium excretion GO:0035929 steroid hormone secretion GO:0035930 corticosteroid hormone secretion GO:0035931 mineralocorticoid secretion GO:0035932 aldosterone secretion GO:0038127 ERBB signaling pathway GO:0038179 neurotrophin signaling pathway GO:0040017 positive regulation of locomotion GO:0042058 regulation of epidermal growth factor receptor signaling pathway GO:0042310 vasoconstriction GO:0042311 vasodilation GO:0042312 regulation of vasodilation GO:0042445 hormone metabolic process GO:0042554 superoxide anion generation GO:0042692 muscle cell differentiation GO:0042756 drinking behavior GO:0042976 activation of Janus kinase activity GO:0042977 activation of JAK2 kinase activity GO:0043062 extracellular structure organization GO:0043090 amino acid import GO:0043091 L-arginine import GO:0043092 L-amino acid import GO:0043434 response to peptide hormone GO:0043500 muscle adaptation GO:0043502 regulation of muscle adaptation GO:0043542 endothelial cell migration GO:0044057 regulation of system process GO:0044060 regulation of endocrine process GO:0044062 regulation of excretion GO:0044089 positive regulation of cellular component biogenesis GO:0044381 glucose import in response to insulin stimulus GO:0044706 multi-multicellular organism process GO:0044744 protein targeting to nucleus GO:0045216 cell-cell junction organization GO:0045428 regulation of nitric oxide biosynthetic process GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway GO:0045765 regulation of angiogenesis GO:0045777 positive regulation of blood pressure GO:0045834 positive regulation of lipid metabolic process GO:0045860 positive regulation of protein kinase activity GO:0045861 negative regulation of proteolysis GO:0045909 positive regulation of vasodilation GO:0045926 negative regulation of growth GO:0045940 positive regulation of steroid metabolic process GO:0046209 nitric oxide metabolic process GO:0046323 glucose import GO:0046324 regulation of glucose import GO:0046326 positive regulation of glucose import GO:0046425 regulation of JAK-STAT cascade GO:0046427 positive regulation of JAK-STAT cascade GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0048011 neurotrophin TRK receptor signaling pathway GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048144 fibroblast proliferation GO:0048145 regulation of fibroblast proliferation GO:0048146 positive regulation of fibroblast proliferation GO:0048167 regulation of synaptic plasticity GO:0048168 regulation of neuronal synaptic plasticity GO:0048169 regulation of long-term neuronal synaptic plasticity GO:0048243 norepinephrine secretion GO:0048514 blood vessel morphogenesis GO:0048588 developmental cell growth GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0048738 cardiac muscle tissue development GO:0048754 branching morphogenesis of an epithelial tube GO:0048771 tissue remodeling GO:0050432 catecholamine secretion GO:0050433 regulation of catecholamine secretion GO:0050663 cytokine secretion GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050730 regulation of peptidyl-tyrosine phosphorylation GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation GO:0050804 modulation of synaptic transmission GO:0050880 regulation of blood vessel size GO:0050886 endocrine process GO:0051047 positive regulation of secretion GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0051146 striated muscle cell differentiation GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051272 positive regulation of cellular component movement GO:0051341 regulation of oxidoreductase activity GO:0051346 negative regulation of hydrolase activity GO:0051353 positive regulation of oxidoreductase activity GO:0051386 regulation of neurotrophin TRK receptor signaling pathway GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway GO:0051403 stress-activated MAPK cascade GO:0051480 regulation of cytosolic calcium ion concentration GO:0051604 protein maturation GO:0051924 regulation of calcium ion transport GO:0051937 catecholamine transport GO:0051952 regulation of amine transport GO:0051954 positive regulation of amine transport GO:0051955 regulation of amino acid transport GO:0051957 positive regulation of amino acid transport GO:0051969 regulation of transmission of nerve impulse GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0055006 cardiac cell development GO:0055007 cardiac muscle cell differentiation GO:0055013 cardiac muscle cell development GO:0055017 cardiac muscle tissue growth GO:0055067 monovalent inorganic cation homeostasis GO:0055074 calcium ion homeostasis GO:0055078 sodium ion homeostasis GO:0060047 heart contraction GO:0060177 regulation of angiotensin metabolic process GO:0060191 regulation of lipase activity GO:0060193 positive regulation of lipase activity GO:0060419 heart growth GO:0060537 muscle tissue development GO:0060562 epithelial tube morphogenesis GO:0060675 ureteric bud morphogenesis GO:0060688 regulation of morphogenesis of a branching structure GO:0060986 endocrine hormone secretion GO:0060993 kidney morphogenesis GO:0061049 cell growth involved in cardiac muscle cell development GO:0061097 regulation of protein tyrosine kinase activity GO:0061098 positive regulation of protein tyrosine kinase activity GO:0061138 morphogenesis of a branching epithelium GO:0061213 positive regulation of mesonephros development GO:0061217 regulation of mesonephros development GO:0061326 renal tubule development GO:0061333 renal tubule morphogenesis GO:0061337 cardiac conduction GO:0061461 L-lysine import GO:0070278 extracellular matrix constituent secretion GO:0070371 ERK1 and ERK2 cascade GO:0070471 uterine smooth muscle contraction GO:0070838 divalent metal ion transport GO:0071214 cellular response to abiotic stimulus GO:0071260 cellular response to mechanical stimulus GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0071496 cellular response to external stimulus GO:0071825 protein-lipid complex subunit organization GO:0071827 plasma lipoprotein particle organization GO:0072001 renal system development GO:0072006 nephron development GO:0072009 nephron epithelium development GO:0072028 nephron morphogenesis GO:0072073 kidney epithelium development GO:0072078 nephron tubule morphogenesis GO:0072080 nephron tubule development GO:0072088 nephron epithelium morphogenesis GO:0072163 mesonephric epithelium development GO:0072164 mesonephric tubule development GO:0072171 mesonephric tubule morphogenesis GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072511 divalent inorganic cation transport GO:0072593 reactive oxygen species metabolic process GO:0085029 extracellular matrix assembly GO:0090066 regulation of anatomical structure size GO:0090077 foam cell differentiation GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090183 regulation of kidney development GO:0090184 positive regulation of kidney development GO:0090189 regulation of branching involved in ureteric bud morphogenesis GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis GO:0090257 regulation of muscle system process GO:0090287 regulation of cellular response to growth factor stimulus GO:0090288 negative regulation of cellular response to growth factor stimulus GO:0090322 regulation of superoxide metabolic process GO:0090467 arginine import GO:0097006 regulation of plasma lipoprotein particle levels GO:0097191 extrinsic apoptotic signaling pathway GO:0097696 STAT cascade GO:0098657 import into cell GO:0098801 regulation of renal system process GO:1900076 regulation of cellular response to insulin stimulus GO:1900078 positive regulation of cellular response to insulin stimulus GO:1900274 regulation of phospholipase C activity GO:1901042 positive regulation of L-arginine import GO:1901184 regulation of ERBB signaling pathway GO:1901186 positive regulation of ERBB signaling pathway GO:1901201 regulation of extracellular matrix assembly GO:1901342 regulation of vasculature development GO:1901343 negative regulation of vasculature development GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1901888 regulation of cell junction assembly GO:1901890 positive regulation of cell junction assembly GO:1902022 L-lysine transport GO:1902023 L-arginine transport GO:1902593 single-organism nuclear import GO:1902765 L-arginine import into cell GO:1902826 regulation of L-arginine import into cell GO:1902828 positive regulation of L-arginine import into cell GO:1902837 amino acid import into cell GO:1903053 regulation of extracellular matrix organization GO:1903055 positive regulation of extracellular matrix organization GO:1903409 reactive oxygen species biosynthetic process GO:1903410 L-lysine import into cell GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903428 positive regulation of reactive oxygen species biosynthetic process GO:1903522 regulation of blood circulation GO:1903524 positive regulation of blood circulation GO:1903532 positive regulation of secretion by cell GO:1903596 regulation of gap junction assembly GO:1903598 positive regulation of gap junction assembly GO:1903779 regulation of cardiac conduction GO:1904407 positive regulation of nitric oxide metabolic process GO:1904705 regulation of vascular smooth muscle cell proliferation GO:1904707 positive regulation of vascular smooth muscle cell proliferation GO:1904738 vascular associated smooth muscle cell migration GO:1904752 regulation of vascular associated smooth muscle cell migration GO:1904754 positive regulation of vascular associated smooth muscle cell migration GO:1904892 regulation of STAT cascade GO:1904894 positive regulation of STAT cascade GO:1905008 regulation of L-lysine import into cell GO:1905010 positive regulation of L-lysine import into cell GO:1905330 regulation of morphogenesis of an epithelium GO:1905332 positive regulation of morphogenesis of an epithelium GO:1990874 vascular smooth muscle cell proliferation GO:2000021 regulation of ion homeostasis GO:2000027 regulation of organ morphogenesis GO:2000147 positive regulation of cell motility GO:2000181 negative regulation of blood vessel morphogenesis GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2000831 regulation of steroid hormone secretion GO:2000846 regulation of corticosteroid hormone secretion GO:2000855 regulation of mineralocorticoid secretion GO:2000858 regulation of aldosterone secretion GO:2001057 reactive nitrogen species metabolic process GO:2001233 regulation of apoptotic signaling pathway GO:2001235 positive regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001238 positive regulation of extrinsic apoptotic signaling pathway GO:2001273 regulation of glucose import in response to insulin stimulus GO:2001275 positive regulation of glucose import in response to insulin stimulus |
Molecular Function |
GO:0001664 G-protein coupled receptor binding GO:0004857 enzyme inhibitor activity GO:0004866 endopeptidase inhibitor activity GO:0004867 serine-type endopeptidase inhibitor activity GO:0005179 hormone activity GO:0008083 growth factor activity GO:0030414 peptidase inhibitor activity GO:0031701 angiotensin receptor binding GO:0031702 type 1 angiotensin receptor binding GO:0031703 type 2 angiotensin receptor binding GO:0061134 peptidase regulator activity GO:0061135 endopeptidase regulator activity |
Cellular Component |
GO:0072562 blood microparticle |
KEGG |
hsa04614 Renin-angiotensin system |
Reactome |
R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-418594: G alpha (i) signalling events R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-1430728: Metabolism R-HSA-2022377: Metabolism of Angiotensinogen to Angiotensins R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-392499: Metabolism of proteins R-HSA-1989781: PPARA activates gene expression R-HSA-2980736: Peptide hormone metabolism R-HSA-375276: Peptide ligand-binding receptors R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR |
Summary | |
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Symbol | AGT |
Name | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
Aliases | SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ...... |
Chromosomal Location | 1q42.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between AGT and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | AGT |
Name | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
Aliases | SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ...... |
Chromosomal Location | 1q42.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of AGT in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | AGT |
Name | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
Aliases | SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ...... |
Chromosomal Location | 1q42.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of AGT in various data sets.
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Points in the above scatter plot represent the mutation difference of AGT in various data sets.
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Summary | |
---|---|
Symbol | AGT |
Name | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
Aliases | SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ...... |
Chromosomal Location | 1q42.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AGT. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | AGT |
Name | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
Aliases | SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ...... |
Chromosomal Location | 1q42.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AGT. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AGT. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | AGT |
Name | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
Aliases | SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ...... |
Chromosomal Location | 1q42.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AGT. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | AGT |
Name | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
Aliases | SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ...... |
Chromosomal Location | 1q42.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of AGT expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | AGT |
Name | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
Aliases | SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ...... |
Chromosomal Location | 1q42.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between AGT and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | AGT |
Name | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
Aliases | SERPINA8; ANHU; angiotensin I; angiotensin II; pre-angiotensinogen; serine (or cysteine) proteinase inhibito ...... |
Chromosomal Location | 1q42.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting AGT collected from DrugBank database. |
Details on drugs targeting AGT.
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