Summary | |
---|---|
Symbol | AGTR1 |
Name | angiotensin II receptor, type 1 |
Aliases | AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ...... |
Chromosomal Location | 3q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Domain |
PF00001 7 transmembrane receptor (rhodopsin family) |
Function |
Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. |
Biological Process |
GO:0001558 regulation of cell growth GO:0001655 urogenital system development GO:0001822 kidney development GO:0001990 regulation of systemic arterial blood pressure by hormone GO:0002016 regulation of blood volume by renin-angiotensin GO:0002018 renin-angiotensin regulation of aldosterone production GO:0002034 regulation of blood vessel size by renin-angiotensin GO:0003013 circulatory system process GO:0003014 renal system process GO:0003018 vascular process in circulatory system GO:0003044 regulation of systemic arterial blood pressure mediated by a chemical signal GO:0003071 renal system process involved in regulation of systemic arterial blood pressure GO:0003072 renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure GO:0003073 regulation of systemic arterial blood pressure GO:0003081 regulation of systemic arterial blood pressure by renin-angiotensin GO:0006869 lipid transport GO:0006874 cellular calcium ion homeostasis GO:0006875 cellular metal ion homeostasis GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007265 Ras protein signal transduction GO:0007266 Rho protein signal transduction GO:0007588 excretion GO:0008015 blood circulation GO:0008202 steroid metabolic process GO:0008217 regulation of blood pressure GO:0009914 hormone transport GO:0010517 regulation of phospholipase activity GO:0010518 positive regulation of phospholipase activity GO:0010742 macrophage derived foam cell differentiation GO:0010743 regulation of macrophage derived foam cell differentiation GO:0010744 positive regulation of macrophage derived foam cell differentiation GO:0010817 regulation of hormone levels GO:0010872 regulation of cholesterol esterification GO:0010873 positive regulation of cholesterol esterification GO:0010876 lipid localization GO:0015850 organic hydroxy compound transport GO:0016049 cell growth GO:0019216 regulation of lipid metabolic process GO:0019218 regulation of steroid metabolic process GO:0019229 regulation of vasoconstriction GO:0019722 calcium-mediated signaling GO:0019932 second-messenger-mediated signaling GO:0023061 signal release GO:0030258 lipid modification GO:0031349 positive regulation of defense response GO:0032103 positive regulation of response to external stimulus GO:0032368 regulation of lipid transport GO:0032429 regulation of phospholipase A2 activity GO:0032430 positive regulation of phospholipase A2 activity GO:0032844 regulation of homeostatic process GO:0033860 regulation of NAD(P)H oxidase activity GO:0033864 positive regulation of NAD(P)H oxidase activity GO:0034367 macromolecular complex remodeling GO:0034368 protein-lipid complex remodeling GO:0034369 plasma lipoprotein particle remodeling GO:0034374 low-density lipoprotein particle remodeling GO:0034433 steroid esterification GO:0034434 sterol esterification GO:0034435 cholesterol esterification GO:0035150 regulation of tube size GO:0035812 renal sodium excretion GO:0035813 regulation of renal sodium excretion GO:0035929 steroid hormone secretion GO:0035930 corticosteroid hormone secretion GO:0035931 mineralocorticoid secretion GO:0035932 aldosterone secretion GO:0038166 angiotensin-activated signaling pathway GO:0042310 vasoconstriction GO:0042311 vasodilation GO:0042312 regulation of vasodilation GO:0043434 response to peptide hormone GO:0044057 regulation of system process GO:0044060 regulation of endocrine process GO:0044062 regulation of excretion GO:0045834 positive regulation of lipid metabolic process GO:0045940 positive regulation of steroid metabolic process GO:0046879 hormone secretion GO:0046883 regulation of hormone secretion GO:0050727 regulation of inflammatory response GO:0050729 positive regulation of inflammatory response GO:0050880 regulation of blood vessel size GO:0050886 endocrine process GO:0051341 regulation of oxidoreductase activity GO:0051353 positive regulation of oxidoreductase activity GO:0051480 regulation of cytosolic calcium ion concentration GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway GO:0055067 monovalent inorganic cation homeostasis GO:0055074 calcium ion homeostasis GO:0055078 sodium ion homeostasis GO:0060191 regulation of lipase activity GO:0060193 positive regulation of lipase activity GO:0060326 cell chemotaxis GO:0060986 endocrine hormone secretion GO:0071375 cellular response to peptide hormone stimulus GO:0071417 cellular response to organonitrogen compound GO:0071825 protein-lipid complex subunit organization GO:0071827 plasma lipoprotein particle organization GO:0072001 renal system development GO:0072503 cellular divalent inorganic cation homeostasis GO:0072507 divalent inorganic cation homeostasis GO:0072593 reactive oxygen species metabolic process GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway GO:0090066 regulation of anatomical structure size GO:0090077 foam cell differentiation GO:0097006 regulation of plasma lipoprotein particle levels GO:0098801 regulation of renal system process GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1903522 regulation of blood circulation GO:1904385 cellular response to angiotensin GO:1990776 response to angiotensin GO:2000021 regulation of ion homeostasis GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2000831 regulation of steroid hormone secretion GO:2000846 regulation of corticosteroid hormone secretion GO:2000855 regulation of mineralocorticoid secretion GO:2000858 regulation of aldosterone secretion |
Molecular Function |
GO:0001595 angiotensin receptor activity GO:0001596 angiotensin type I receptor activity GO:0001653 peptide receptor activity GO:0001664 G-protein coupled receptor binding GO:0004945 angiotensin type II receptor activity GO:0008528 G-protein coupled peptide receptor activity GO:0031711 bradykinin receptor binding GO:0046982 protein heterodimerization activity |
Cellular Component | - |
KEGG |
hsa04020 Calcium signaling pathway hsa04022 cGMP-PKG signaling pathway hsa04080 Neuroactive ligand-receptor interaction hsa04261 Adrenergic signaling in cardiomyocytes hsa04270 Vascular smooth muscle contraction hsa04614 Renin-angiotensin system |
Reactome |
R-HSA-8856825: Cargo recognition for clathrin-mediated endocytosis R-HSA-373076: Class A/1 (Rhodopsin-like receptors) R-HSA-8856828: Clathrin-mediated endocytosis R-HSA-416476: G alpha (q) signalling events R-HSA-388396: GPCR downstream signaling R-HSA-500792: GPCR ligand binding R-HSA-881907: Gastrin-CREB signalling pathway via PKC and MAPK R-HSA-199991: Membrane Trafficking R-HSA-375276: Peptide ligand-binding receptors R-HSA-162582: Signal Transduction R-HSA-372790: Signaling by GPCR R-HSA-5653656: Vesicle-mediated transport |
Summary | |
---|---|
Symbol | AGTR1 |
Name | angiotensin II receptor, type 1 |
Aliases | AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ...... |
Chromosomal Location | 3q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between AGTR1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between AGTR1 and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | AGTR1 |
Name | angiotensin II receptor, type 1 |
Aliases | AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ...... |
Chromosomal Location | 3q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of AGTR1 in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | AGTR1 |
Name | angiotensin II receptor, type 1 |
Aliases | AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ...... |
Chromosomal Location | 3q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of AGTR1 in various data sets.
|
Points in the above scatter plot represent the mutation difference of AGTR1 in various data sets.
|
Summary | |
---|---|
Symbol | AGTR1 |
Name | angiotensin II receptor, type 1 |
Aliases | AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ...... |
Chromosomal Location | 3q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AGTR1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | AGTR1 |
Name | angiotensin II receptor, type 1 |
Aliases | AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ...... |
Chromosomal Location | 3q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AGTR1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AGTR1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | AGTR1 |
Name | angiotensin II receptor, type 1 |
Aliases | AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ...... |
Chromosomal Location | 3q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AGTR1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | AGTR1 |
Name | angiotensin II receptor, type 1 |
Aliases | AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ...... |
Chromosomal Location | 3q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of AGTR1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | AGTR1 |
Name | angiotensin II receptor, type 1 |
Aliases | AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ...... |
Chromosomal Location | 3q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between AGTR1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | AGTR1 |
Name | angiotensin II receptor, type 1 |
Aliases | AT2R1; AGTR1A; AT2R1A; HAT1R; AG2S; AT2R1B; AT1B; AGTR1B; angiotensin receptor 1B; AG2SB; AT1AR; AT1BR; AT1R ...... |
Chromosomal Location | 3q24 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting AGTR1 collected from DrugBank database. |
Details on drugs targeting AGTR1.
|