Summary | |
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Symbol | AHR |
Name | aryl hydrocarbon receptor |
Aliases | bHLHe76; AH-receptor; ah receptor; aromatic hydrocarbon receptor; class E basic helix-loop-helix protein 76 |
Chromosomal Location | 7p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Note=Initially cytoplasmic; upon binding with ligand and interaction with a HSP90, it translocates to the nucleus. |
Domain |
PF00010 Helix-loop-helix DNA-binding domain PF00989 PAS fold PF08447 PAS fold |
Function |
Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. |
Biological Process |
GO:0002694 regulation of leukocyte activation GO:0006805 xenobiotic metabolic process GO:0007623 circadian rhythm GO:0009410 response to xenobiotic stimulus GO:0009636 response to toxic substance GO:0030522 intracellular receptor signaling pathway GO:0030888 regulation of B cell proliferation GO:0032922 circadian regulation of gene expression GO:0032943 mononuclear cell proliferation GO:0032944 regulation of mononuclear cell proliferation GO:0042100 B cell proliferation GO:0042113 B cell activation GO:0046651 lymphocyte proliferation GO:0048511 rhythmic process GO:0050670 regulation of lymphocyte proliferation GO:0050864 regulation of B cell activation GO:0050865 regulation of cell activation GO:0051249 regulation of lymphocyte activation GO:0070661 leukocyte proliferation GO:0070663 regulation of leukocyte proliferation GO:0071466 cellular response to xenobiotic stimulus |
Molecular Function |
GO:0004874 aryl hydrocarbon receptor activity GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding GO:0008134 transcription factor binding GO:0031072 heat shock protein binding GO:0035326 enhancer binding GO:0046982 protein heterodimerization activity GO:0051879 Hsp90 protein binding GO:0070888 E-box binding GO:0098531 transcription factor activity, direct ligand regulated sequence-specific DNA binding |
Cellular Component |
GO:0005667 transcription factor complex GO:0034751 aryl hydrocarbon receptor complex GO:0034752 cytosolic aryl hydrocarbon receptor complex GO:0034753 nuclear aryl hydrocarbon receptor complex GO:0043235 receptor complex GO:0044445 cytosolic part |
KEGG | - |
Reactome |
R-HSA-8937144: Aryl hydrocarbon receptor signalling R-HSA-211859: Biological oxidations R-HSA-211897: Cytochrome P450 - arranged by substrate type R-HSA-211976: Endogenous sterols R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1989781: PPARA activates gene expression R-HSA-211945: Phase 1 - Functionalization of compounds R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-HSA-211981: Xenobiotics |
Summary | |
---|---|
Symbol | AHR |
Name | aryl hydrocarbon receptor |
Aliases | bHLHe76; AH-receptor; ah receptor; aromatic hydrocarbon receptor; class E basic helix-loop-helix protein 76 |
Chromosomal Location | 7p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between AHR and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between AHR and anti-tumor immunity in human cancer.
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Summary | |
---|---|
Symbol | AHR |
Name | aryl hydrocarbon receptor |
Aliases | bHLHe76; AH-receptor; ah receptor; aromatic hydrocarbon receptor; class E basic helix-loop-helix protein 76 |
Chromosomal Location | 7p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of AHR in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | AHR |
Name | aryl hydrocarbon receptor |
Aliases | bHLHe76; AH-receptor; ah receptor; aromatic hydrocarbon receptor; class E basic helix-loop-helix protein 76 |
Chromosomal Location | 7p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of AHR in various data sets.
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Points in the above scatter plot represent the mutation difference of AHR in various data sets.
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Summary | |
---|---|
Symbol | AHR |
Name | aryl hydrocarbon receptor |
Aliases | bHLHe76; AH-receptor; ah receptor; aromatic hydrocarbon receptor; class E basic helix-loop-helix protein 76 |
Chromosomal Location | 7p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AHR. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | AHR |
Name | aryl hydrocarbon receptor |
Aliases | bHLHe76; AH-receptor; ah receptor; aromatic hydrocarbon receptor; class E basic helix-loop-helix protein 76 |
Chromosomal Location | 7p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AHR. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AHR. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | AHR |
Name | aryl hydrocarbon receptor |
Aliases | bHLHe76; AH-receptor; ah receptor; aromatic hydrocarbon receptor; class E basic helix-loop-helix protein 76 |
Chromosomal Location | 7p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AHR. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | AHR |
Name | aryl hydrocarbon receptor |
Aliases | bHLHe76; AH-receptor; ah receptor; aromatic hydrocarbon receptor; class E basic helix-loop-helix protein 76 |
Chromosomal Location | 7p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of AHR expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | AHR |
Name | aryl hydrocarbon receptor |
Aliases | bHLHe76; AH-receptor; ah receptor; aromatic hydrocarbon receptor; class E basic helix-loop-helix protein 76 |
Chromosomal Location | 7p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between AHR and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | AHR |
Name | aryl hydrocarbon receptor |
Aliases | bHLHe76; AH-receptor; ah receptor; aromatic hydrocarbon receptor; class E basic helix-loop-helix protein 76 |
Chromosomal Location | 7p15 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting AHR collected from DrugBank database. |
Details on drugs targeting AHR.
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