Browse AIP

Summary
SymbolAIP
Namearyl hydrocarbon receptor interacting protein
Aliases XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ......
Chromosomal Location11q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm.
Domain PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase
Function

May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.; FUNCTION: Cellular negative regulator of the hepatitis B virus (HBV) X protein.

> Gene Ontology
 
Biological Process GO:0006457 protein folding
GO:0006626 protein targeting to mitochondrion
GO:0006805 xenobiotic metabolic process
GO:0006839 mitochondrial transport
GO:0009410 response to xenobiotic stimulus
GO:0010737 protein kinase A signaling
GO:0010738 regulation of protein kinase A signaling
GO:0022417 protein maturation by protein folding
GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity
GO:0051346 negative regulation of hydrolase activity
GO:0051604 protein maturation
GO:0070585 protein localization to mitochondrion
GO:0071466 cellular response to xenobiotic stimulus
GO:0072655 establishment of protein localization to mitochondrion
Molecular Function GO:0003713 transcription coactivator activity
GO:0008134 transcription factor binding
GO:0017162 aryl hydrocarbon receptor binding
GO:0036004 GAF domain binding
GO:0051082 unfolded protein binding
Cellular Component GO:0034751 aryl hydrocarbon receptor complex
GO:0043235 receptor complex
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-8937144: Aryl hydrocarbon receptor signalling
R-HSA-211859: Biological oxidations
R-HSA-1430728: Metabolism
R-HSA-211945: Phase 1 - Functionalization of compounds
Summary
SymbolAIP
Namearyl hydrocarbon receptor interacting protein
Aliases XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ......
Chromosomal Location11q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between AIP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolAIP
Namearyl hydrocarbon receptor interacting protein
Aliases XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ......
Chromosomal Location11q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of AIP in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.27; FDR: 0.02150 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolAIP
Namearyl hydrocarbon receptor interacting protein
Aliases XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ......
Chromosomal Location11q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of AIP in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.120.681
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.3350.897
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.0440.983
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2350.443
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2150.904
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.2610.909
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.110.763
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.0240.987
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.280.865
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.0080.997
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.0540.985
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 682300.0340.615
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of AIP in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolAIP
Namearyl hydrocarbon receptor interacting protein
Aliases XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ......
Chromosomal Location11q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AIP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolAIP
Namearyl hydrocarbon receptor interacting protein
Aliases XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ......
Chromosomal Location11q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AIP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AIP.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolAIP
Namearyl hydrocarbon receptor interacting protein
Aliases XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ......
Chromosomal Location11q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AIP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolAIP
Namearyl hydrocarbon receptor interacting protein
Aliases XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ......
Chromosomal Location11q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of AIP expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolAIP
Namearyl hydrocarbon receptor interacting protein
Aliases XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ......
Chromosomal Location11q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between AIP and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolAIP
Namearyl hydrocarbon receptor interacting protein
Aliases XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ......
Chromosomal Location11q13.3
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting AIP collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.