Summary | |
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Symbol | AIP |
Name | aryl hydrocarbon receptor interacting protein |
Aliases | XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ...... |
Chromosomal Location | 11q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. |
Domain |
PF00254 FKBP-type peptidyl-prolyl cis-trans isomerase |
Function |
May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting.; FUNCTION: Cellular negative regulator of the hepatitis B virus (HBV) X protein. |
Biological Process |
GO:0006457 protein folding GO:0006626 protein targeting to mitochondrion GO:0006805 xenobiotic metabolic process GO:0006839 mitochondrial transport GO:0009410 response to xenobiotic stimulus GO:0010737 protein kinase A signaling GO:0010738 regulation of protein kinase A signaling GO:0022417 protein maturation by protein folding GO:0051342 regulation of cyclic-nucleotide phosphodiesterase activity GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity GO:0051346 negative regulation of hydrolase activity GO:0051604 protein maturation GO:0070585 protein localization to mitochondrion GO:0071466 cellular response to xenobiotic stimulus GO:0072655 establishment of protein localization to mitochondrion |
Molecular Function |
GO:0003713 transcription coactivator activity GO:0008134 transcription factor binding GO:0017162 aryl hydrocarbon receptor binding GO:0036004 GAF domain binding GO:0051082 unfolded protein binding |
Cellular Component |
GO:0034751 aryl hydrocarbon receptor complex GO:0043235 receptor complex |
KEGG | - |
Reactome |
R-HSA-8937144: Aryl hydrocarbon receptor signalling R-HSA-211859: Biological oxidations R-HSA-1430728: Metabolism R-HSA-211945: Phase 1 - Functionalization of compounds |
Summary | |
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Symbol | AIP |
Name | aryl hydrocarbon receptor interacting protein |
Aliases | XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ...... |
Chromosomal Location | 11q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between AIP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | AIP |
Name | aryl hydrocarbon receptor interacting protein |
Aliases | XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ...... |
Chromosomal Location | 11q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of AIP in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | AIP |
Name | aryl hydrocarbon receptor interacting protein |
Aliases | XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ...... |
Chromosomal Location | 11q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of AIP in various data sets.
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Points in the above scatter plot represent the mutation difference of AIP in various data sets.
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Summary | |
---|---|
Symbol | AIP |
Name | aryl hydrocarbon receptor interacting protein |
Aliases | XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ...... |
Chromosomal Location | 11q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AIP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | AIP |
Name | aryl hydrocarbon receptor interacting protein |
Aliases | XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ...... |
Chromosomal Location | 11q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AIP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AIP. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | AIP |
Name | aryl hydrocarbon receptor interacting protein |
Aliases | XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ...... |
Chromosomal Location | 11q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AIP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | AIP |
Name | aryl hydrocarbon receptor interacting protein |
Aliases | XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ...... |
Chromosomal Location | 11q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of AIP expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | AIP |
Name | aryl hydrocarbon receptor interacting protein |
Aliases | XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ...... |
Chromosomal Location | 11q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between AIP and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | AIP |
Name | aryl hydrocarbon receptor interacting protein |
Aliases | XAP2; ARA9; FKBP16; aryl hydrocarbon receptor-interacting protein; FKBP37; SMTPHN; HBV X-associated protein ...... |
Chromosomal Location | 11q13.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting AIP collected from DrugBank database. |
There is no record. |