Browse AKT1

Summary
SymbolAKT1
Namev-akt murine thymoma viral oncogene homolog 1
Aliases RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ......
Chromosomal Location14q32.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm. Nucleus. Cell membrane. Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus. Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529).
Domain PF00169 PH domain
PF00069 Protein kinase domain
PF00433 Protein kinase C terminal domain
Function

AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development. Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD stimulates its pro-apoptotic activity. Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53.; FUNCTION: AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.

> Gene Ontology
 
Biological Process GO:0000060 protein import into nucleus, translocation
GO:0000075 cell cycle checkpoint
GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000271 polysaccharide biosynthetic process
GO:0001503 ossification
GO:0001558 regulation of cell growth
GO:0001649 osteoblast differentiation
GO:0001666 response to hypoxia
GO:0001667 ameboidal-type cell migration
GO:0001701 in utero embryonic development
GO:0001776 leukocyte homeostasis
GO:0001836 release of cytochrome c from mitochondria
GO:0001890 placenta development
GO:0001892 embryonic placenta development
GO:0001893 maternal placenta development
GO:0001933 negative regulation of protein phosphorylation
GO:0001935 endothelial cell proliferation
GO:0001936 regulation of endothelial cell proliferation
GO:0001938 positive regulation of endothelial cell proliferation
GO:0002028 regulation of sodium ion transport
GO:0002237 response to molecule of bacterial origin
GO:0002260 lymphocyte homeostasis
GO:0002694 regulation of leukocyte activation
GO:0002696 positive regulation of leukocyte activation
GO:0003013 circulatory system process
GO:0003018 vascular process in circulatory system
GO:0005976 polysaccharide metabolic process
GO:0005977 glycogen metabolic process
GO:0005978 glycogen biosynthetic process
GO:0005979 regulation of glycogen biosynthetic process
GO:0005996 monosaccharide metabolic process
GO:0006006 glucose metabolic process
GO:0006022 aminoglycan metabolic process
GO:0006073 cellular glucan metabolic process
GO:0006091 generation of precursor metabolites and energy
GO:0006109 regulation of carbohydrate metabolic process
GO:0006112 energy reserve metabolic process
GO:0006417 regulation of translation
GO:0006469 negative regulation of protein kinase activity
GO:0006606 protein import into nucleus
GO:0006631 fatty acid metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0006809 nitric oxide biosynthetic process
GO:0006814 sodium ion transport
GO:0006820 anion transport
GO:0006869 lipid transport
GO:0006913 nucleocytoplasmic transport
GO:0006914 autophagy
GO:0006924 activation-induced cell death of T cells
GO:0006979 response to oxidative stress
GO:0007009 plasma membrane organization
GO:0007159 leukocyte cell-cell adhesion
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007254 JNK cascade
GO:0007272 ensheathment of neurons
GO:0007281 germ cell development
GO:0007346 regulation of mitotic cell cycle
GO:0007422 peripheral nervous system development
GO:0007565 female pregnancy
GO:0007568 aging
GO:0007596 blood coagulation
GO:0007599 hemostasis
GO:0008015 blood circulation
GO:0008286 insulin receptor signaling pathway
GO:0008361 regulation of cell size
GO:0008366 axon ensheathment
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0008637 apoptotic mitochondrial changes
GO:0008643 carbohydrate transport
GO:0008645 hexose transport
GO:0009062 fatty acid catabolic process
GO:0009250 glucan biosynthetic process
GO:0009266 response to temperature stimulus
GO:0009314 response to radiation
GO:0009408 response to heat
GO:0009411 response to UV
GO:0009416 response to light stimulus
GO:0009612 response to mechanical stimulus
GO:0009894 regulation of catabolic process
GO:0009895 negative regulation of catabolic process
GO:0009896 positive regulation of catabolic process
GO:0009991 response to extracellular stimulus
GO:0010001 glial cell differentiation
GO:0010466 negative regulation of peptidase activity
GO:0010498 proteasomal protein catabolic process
GO:0010506 regulation of autophagy
GO:0010507 negative regulation of autophagy
GO:0010565 regulation of cellular ketone metabolic process
GO:0010594 regulation of endothelial cell migration
GO:0010595 positive regulation of endothelial cell migration
GO:0010608 posttranscriptional regulation of gene expression
GO:0010631 epithelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010634 positive regulation of epithelial cell migration
GO:0010639 negative regulation of organelle organization
GO:0010675 regulation of cellular carbohydrate metabolic process
GO:0010676 positive regulation of cellular carbohydrate metabolic process
GO:0010746 regulation of plasma membrane long-chain fatty acid transport
GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport
GO:0010761 fibroblast migration
GO:0010762 regulation of fibroblast migration
GO:0010763 positive regulation of fibroblast migration
GO:0010765 positive regulation of sodium ion transport
GO:0010821 regulation of mitochondrion organization
GO:0010823 negative regulation of mitochondrion organization
GO:0010827 regulation of glucose transport
GO:0010828 positive regulation of glucose transport
GO:0010876 lipid localization
GO:0010906 regulation of glucose metabolic process
GO:0010907 positive regulation of glucose metabolic process
GO:0010951 negative regulation of endopeptidase activity
GO:0010959 regulation of metal ion transport
GO:0010962 regulation of glucan biosynthetic process
GO:0010975 regulation of neuron projection development
GO:0014037 Schwann cell differentiation
GO:0014044 Schwann cell development
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0014066 regulation of phosphatidylinositol 3-kinase signaling
GO:0015672 monovalent inorganic cation transport
GO:0015711 organic anion transport
GO:0015718 monocarboxylic acid transport
GO:0015749 monosaccharide transport
GO:0015758 glucose transport
GO:0015849 organic acid transport
GO:0015908 fatty acid transport
GO:0015909 long-chain fatty acid transport
GO:0015911 plasma membrane long-chain fatty acid transport
GO:0015980 energy derivation by oxidation of organic compounds
GO:0016042 lipid catabolic process
GO:0016049 cell growth
GO:0016051 carbohydrate biosynthetic process
GO:0016054 organic acid catabolic process
GO:0017038 protein import
GO:0018105 peptidyl-serine phosphorylation
GO:0018107 peptidyl-threonine phosphorylation
GO:0018209 peptidyl-serine modification
GO:0018210 peptidyl-threonine modification
GO:0019216 regulation of lipid metabolic process
GO:0019217 regulation of fatty acid metabolic process
GO:0019229 regulation of vasoconstriction
GO:0019318 hexose metabolic process
GO:0019395 fatty acid oxidation
GO:0021510 spinal cord development
GO:0021782 glial cell development
GO:0022011 myelination in peripheral nervous system
GO:0022407 regulation of cell-cell adhesion
GO:0022409 positive regulation of cell-cell adhesion
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0030168 platelet activation
GO:0030203 glycosaminoglycan metabolic process
GO:0030212 hyaluronan metabolic process
GO:0030258 lipid modification
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030879 mammary gland development
GO:0031016 pancreas development
GO:0031018 endocrine pancreas development
GO:0031098 stress-activated protein kinase signaling cascade
GO:0031294 lymphocyte costimulation
GO:0031295 T cell costimulation
GO:0031329 regulation of cellular catabolic process
GO:0031330 negative regulation of cellular catabolic process
GO:0031331 positive regulation of cellular catabolic process
GO:0031641 regulation of myelination
GO:0031657 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0031667 response to nutrient levels
GO:0031998 regulation of fatty acid beta-oxidation
GO:0031999 negative regulation of fatty acid beta-oxidation
GO:0032069 regulation of nuclease activity
GO:0032070 regulation of deoxyribonuclease activity
GO:0032071 regulation of endodeoxyribonuclease activity
GO:0032075 positive regulation of nuclease activity
GO:0032077 positive regulation of deoxyribonuclease activity
GO:0032079 positive regulation of endodeoxyribonuclease activity
GO:0032094 response to food
GO:0032287 peripheral nervous system myelin maintenance
GO:0032292 peripheral nervous system axon ensheathment
GO:0032368 regulation of lipid transport
GO:0032369 negative regulation of lipid transport
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032496 response to lipopolysaccharide
GO:0032507 maintenance of protein location in cell
GO:0032535 regulation of cellular component size
GO:0032768 regulation of monooxygenase activity
GO:0032770 positive regulation of monooxygenase activity
GO:0032868 response to insulin
GO:0032869 cellular response to insulin stimulus
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0032881 regulation of polysaccharide metabolic process
GO:0032885 regulation of polysaccharide biosynthetic process
GO:0032890 regulation of organic acid transport
GO:0032891 negative regulation of organic acid transport
GO:0033002 muscle cell proliferation
GO:0033135 regulation of peptidyl-serine phosphorylation
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0033500 carbohydrate homeostasis
GO:0033673 negative regulation of kinase activity
GO:0033674 positive regulation of kinase activity
GO:0033692 cellular polysaccharide biosynthetic process
GO:0034248 regulation of cellular amide metabolic process
GO:0034405 response to fluid shear stress
GO:0034440 lipid oxidation
GO:0034504 protein localization to nucleus
GO:0034599 cellular response to oxidative stress
GO:0034637 cellular carbohydrate biosynthetic process
GO:0034694 response to prostaglandin
GO:0034695 response to prostaglandin E
GO:0034762 regulation of transmembrane transport
GO:0034763 negative regulation of transmembrane transport
GO:0034765 regulation of ion transmembrane transport
GO:0034766 negative regulation of ion transmembrane transport
GO:0035150 regulation of tube size
GO:0035270 endocrine system development
GO:0035655 interleukin-18-mediated signaling pathway
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0036293 response to decreased oxygen levels
GO:0036294 cellular response to decreased oxygen levels
GO:0036473 cell death in response to oxidative stress
GO:0038034 signal transduction in absence of ligand
GO:0038127 ERBB signaling pathway
GO:0038128 ERBB2 signaling pathway
GO:0040017 positive regulation of locomotion
GO:0042058 regulation of epidermal growth factor receptor signaling pathway
GO:0042063 gliogenesis
GO:0042110 T cell activation
GO:0042176 regulation of protein catabolic process
GO:0042180 cellular ketone metabolic process
GO:0042310 vasoconstriction
GO:0042326 negative regulation of phosphorylation
GO:0042552 myelination
GO:0042593 glucose homeostasis
GO:0042692 muscle cell differentiation
GO:0043029 T cell homeostasis
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043217 myelin maintenance
GO:0043255 regulation of carbohydrate biosynthetic process
GO:0043270 positive regulation of ion transport
GO:0043271 negative regulation of ion transport
GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043409 negative regulation of MAPK cascade
GO:0043434 response to peptide hormone
GO:0043467 regulation of generation of precursor metabolites and energy
GO:0043487 regulation of RNA stability
GO:0043488 regulation of mRNA stability
GO:0043491 protein kinase B signaling
GO:0043534 blood vessel endothelial cell migration
GO:0043535 regulation of blood vessel endothelial cell migration
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043542 endothelial cell migration
GO:0044042 glucan metabolic process
GO:0044057 regulation of system process
GO:0044070 regulation of anion transport
GO:0044242 cellular lipid catabolic process
GO:0044262 cellular carbohydrate metabolic process
GO:0044264 cellular polysaccharide metabolic process
GO:0044282 small molecule catabolic process
GO:0044706 multi-multicellular organism process
GO:0044723 single-organism carbohydrate metabolic process
GO:0044744 protein targeting to nucleus
GO:0044770 cell cycle phase transition
GO:0044772 mitotic cell cycle phase transition
GO:0044843 cell cycle G1/S phase transition
GO:0045185 maintenance of protein location
GO:0045428 regulation of nitric oxide biosynthetic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045444 fat cell differentiation
GO:0045598 regulation of fat cell differentiation
GO:0045600 positive regulation of fat cell differentiation
GO:0045725 positive regulation of glycogen biosynthetic process
GO:0045732 positive regulation of protein catabolic process
GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045785 positive regulation of cell adhesion
GO:0045787 positive regulation of cell cycle
GO:0045792 negative regulation of cell size
GO:0045833 negative regulation of lipid metabolic process
GO:0045834 positive regulation of lipid metabolic process
GO:0045860 positive regulation of protein kinase activity
GO:0045861 negative regulation of proteolysis
GO:0045862 positive regulation of proteolysis
GO:0045907 positive regulation of vasoconstriction
GO:0045913 positive regulation of carbohydrate metabolic process
GO:0045922 negative regulation of fatty acid metabolic process
GO:0045927 positive regulation of growth
GO:0046209 nitric oxide metabolic process
GO:0046320 regulation of fatty acid oxidation
GO:0046322 negative regulation of fatty acid oxidation
GO:0046323 glucose import
GO:0046324 regulation of glucose import
GO:0046326 positive regulation of glucose import
GO:0046328 regulation of JNK cascade
GO:0046329 negative regulation of JNK cascade
GO:0046395 carboxylic acid catabolic process
GO:0046777 protein autophosphorylation
GO:0046889 positive regulation of lipid biosynthetic process
GO:0046890 regulation of lipid biosynthetic process
GO:0046942 carboxylic acid transport
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0048015 phosphatidylinositol-mediated signaling
GO:0048017 inositol lipid-mediated signaling
GO:0048568 embryonic organ development
GO:0048608 reproductive structure development
GO:0048659 smooth muscle cell proliferation
GO:0048660 regulation of smooth muscle cell proliferation
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0048732 gland development
GO:0048872 homeostasis of number of cells
GO:0050673 epithelial cell proliferation
GO:0050678 regulation of epithelial cell proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050817 coagulation
GO:0050863 regulation of T cell activation
GO:0050865 regulation of cell activation
GO:0050867 positive regulation of cell activation
GO:0050870 positive regulation of T cell activation
GO:0050878 regulation of body fluid levels
GO:0050880 regulation of blood vessel size
GO:0050994 regulation of lipid catabolic process
GO:0050995 negative regulation of lipid catabolic process
GO:0050999 regulation of nitric-oxide synthase activity
GO:0051000 positive regulation of nitric-oxide synthase activity
GO:0051051 negative regulation of transport
GO:0051052 regulation of DNA metabolic process
GO:0051054 positive regulation of DNA metabolic process
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051146 striated muscle cell differentiation
GO:0051169 nuclear transport
GO:0051170 nuclear import
GO:0051220 cytoplasmic sequestering of protein
GO:0051235 maintenance of location
GO:0051249 regulation of lymphocyte activation
GO:0051251 positive regulation of lymphocyte activation
GO:0051272 positive regulation of cellular component movement
GO:0051341 regulation of oxidoreductase activity
GO:0051346 negative regulation of hydrolase activity
GO:0051348 negative regulation of transferase activity
GO:0051353 positive regulation of oxidoreductase activity
GO:0051403 stress-activated MAPK cascade
GO:0051651 maintenance of location in cell
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0060135 maternal process involved in female pregnancy
GO:0060416 response to growth hormone
GO:0060644 mammary gland epithelial cell differentiation
GO:0060674 placenta blood vessel development
GO:0060706 cell differentiation involved in embryonic placenta development
GO:0060709 glycogen cell differentiation involved in embryonic placenta development
GO:0060711 labyrinthine layer development
GO:0060712 spongiotrophoblast layer development
GO:0060716 labyrinthine layer blood vessel development
GO:0061136 regulation of proteasomal protein catabolic process
GO:0061180 mammary gland epithelium development
GO:0061458 reproductive system development
GO:0070141 response to UV-A
GO:0070227 lymphocyte apoptotic process
GO:0070231 T cell apoptotic process
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070303 negative regulation of stress-activated protein kinase signaling cascade
GO:0070482 response to oxygen levels
GO:0070486 leukocyte aggregation
GO:0070489 T cell aggregation
GO:0070585 protein localization to mitochondrion
GO:0070673 response to interleukin-18
GO:0070849 response to epidermal growth factor
GO:0070873 regulation of glycogen metabolic process
GO:0070875 positive regulation of glycogen metabolic process
GO:0070997 neuron death
GO:0071214 cellular response to abiotic stimulus
GO:0071216 cellular response to biotic stimulus
GO:0071219 cellular response to molecule of bacterial origin
GO:0071222 cellular response to lipopolysaccharide
GO:0071260 cellular response to mechanical stimulus
GO:0071351 cellular response to interleukin-18
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071375 cellular response to peptide hormone stimulus
GO:0071379 cellular response to prostaglandin stimulus
GO:0071380 cellular response to prostaglandin E stimulus
GO:0071396 cellular response to lipid
GO:0071407 cellular response to organic cyclic compound
GO:0071417 cellular response to organonitrogen compound
GO:0071453 cellular response to oxygen levels
GO:0071456 cellular response to hypoxia
GO:0071496 cellular response to external stimulus
GO:0071593 lymphocyte aggregation
GO:0071887 leukocyte apoptotic process
GO:0071900 regulation of protein serine/threonine kinase activity
GO:0071902 positive regulation of protein serine/threonine kinase activity
GO:0072329 monocarboxylic acid catabolic process
GO:0072331 signal transduction by p53 class mediator
GO:0072593 reactive oxygen species metabolic process
GO:0072595 maintenance of protein localization in organelle
GO:0072655 establishment of protein localization to mitochondrion
GO:0072656 maintenance of protein location in mitochondrion
GO:0072657 protein localization to membrane
GO:0072659 protein localization to plasma membrane
GO:0090002 establishment of protein localization to plasma membrane
GO:0090003 regulation of establishment of protein localization to plasma membrane
GO:0090004 positive regulation of establishment of protein localization to plasma membrane
GO:0090066 regulation of anatomical structure size
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:0090150 establishment of protein localization to membrane
GO:0090199 regulation of release of cytochrome c from mitochondria
GO:0090201 negative regulation of release of cytochrome c from mitochondria
GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:0097012 response to granulocyte macrophage colony-stimulating factor
GO:0097191 extrinsic apoptotic signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:0097193 intrinsic apoptotic signaling pathway
GO:0097194 execution phase of apoptosis
GO:0098656 anion transmembrane transport
GO:0099565 chemical synaptic transmission, postsynaptic
GO:0100002 negative regulation of protein kinase activity by protein phosphorylation
GO:1900180 regulation of protein localization to nucleus
GO:1900182 positive regulation of protein localization to nucleus
GO:1900407 regulation of cellular response to oxidative stress
GO:1900408 negative regulation of cellular response to oxidative stress
GO:1901099 negative regulation of signal transduction in absence of ligand
GO:1901184 regulation of ERBB signaling pathway
GO:1901186 positive regulation of ERBB signaling pathway
GO:1901214 regulation of neuron death
GO:1901215 negative regulation of neuron death
GO:1901652 response to peptide
GO:1901653 cellular response to peptide
GO:1901654 response to ketone
GO:1901655 cellular response to ketone
GO:1901796 regulation of signal transduction by p53 class mediator
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1901976 regulation of cell cycle checkpoint
GO:1901987 regulation of cell cycle phase transition
GO:1901990 regulation of mitotic cell cycle phase transition
GO:1902001 fatty acid transmembrane transport
GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:1902532 negative regulation of intracellular signal transduction
GO:1902593 single-organism nuclear import
GO:1902806 regulation of cell cycle G1/S phase transition
GO:1902882 regulation of response to oxidative stress
GO:1902883 negative regulation of response to oxidative stress
GO:1903037 regulation of leukocyte cell-cell adhesion
GO:1903039 positive regulation of leukocyte cell-cell adhesion
GO:1903050 regulation of proteolysis involved in cellular protein catabolic process
GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process
GO:1903076 regulation of protein localization to plasma membrane
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1903201 regulation of oxidative stress-induced cell death
GO:1903202 negative regulation of oxidative stress-induced cell death
GO:1903362 regulation of cellular protein catabolic process
GO:1903364 positive regulation of cellular protein catabolic process
GO:1903409 reactive oxygen species biosynthetic process
GO:1903426 regulation of reactive oxygen species biosynthetic process
GO:1903428 positive regulation of reactive oxygen species biosynthetic process
GO:1903510 mucopolysaccharide metabolic process
GO:1903522 regulation of blood circulation
GO:1903524 positive regulation of blood circulation
GO:1903729 regulation of plasma membrane organization
GO:1903792 negative regulation of anion transport
GO:1903825 organic acid transmembrane transport
GO:1903829 positive regulation of cellular protein localization
GO:1903959 regulation of anion transmembrane transport
GO:1903960 negative regulation of anion transmembrane transport
GO:1904029 regulation of cyclin-dependent protein kinase activity
GO:1904031 positive regulation of cyclin-dependent protein kinase activity
GO:1904375 regulation of protein localization to cell periphery
GO:1904377 positive regulation of protein localization to cell periphery
GO:1904407 positive regulation of nitric oxide metabolic process
GO:1904951 positive regulation of establishment of protein localization
GO:1905039 carboxylic acid transmembrane transport
GO:1990089 response to nerve growth factor
GO:1990090 cellular response to nerve growth factor stimulus
GO:1990418 response to insulin-like growth factor stimulus
GO:1990778 protein localization to cell periphery
GO:2000045 regulation of G1/S transition of mitotic cell cycle
GO:2000116 regulation of cysteine-type endopeptidase activity
GO:2000117 negative regulation of cysteine-type endopeptidase activity
GO:2000147 positive regulation of cell motility
GO:2000191 regulation of fatty acid transport
GO:2000192 negative regulation of fatty acid transport
GO:2000377 regulation of reactive oxygen species metabolic process
GO:2000379 positive regulation of reactive oxygen species metabolic process
GO:2001057 reactive nitrogen species metabolic process
GO:2001233 regulation of apoptotic signaling pathway
GO:2001234 negative regulation of apoptotic signaling pathway
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO:2001242 regulation of intrinsic apoptotic signaling pathway
GO:2001243 negative regulation of intrinsic apoptotic signaling pathway
Molecular Function GO:0004674 protein serine/threonine kinase activity
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0005080 protein kinase C binding
GO:0005543 phospholipid binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0019902 phosphatase binding
GO:0019903 protein phosphatase binding
GO:0030235 nitric-oxide synthase regulator activity
GO:0032794 GTPase activating protein binding
GO:0035091 phosphatidylinositol binding
GO:0043168 anion binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0051721 protein phosphatase 2A binding
GO:0071889 14-3-3 protein binding
GO:1901981 phosphatidylinositol phosphate binding
Cellular Component GO:0005819 spindle
GO:0005929 cilium
GO:0036064 ciliary basal body
GO:0044441 ciliary part
GO:0098794 postsynapse
> KEGG and Reactome Pathway
 
KEGG hsa04010 MAPK signaling pathway
hsa04012 ErbB signaling pathway
hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04022 cGMP-PKG signaling pathway
hsa04024 cAMP signaling pathway
hsa04062 Chemokine signaling pathway
hsa04066 HIF-1 signaling pathway
hsa04068 FoxO signaling pathway
hsa04071 Sphingolipid signaling pathway
hsa04140 Regulation of autophagy
hsa04150 mTOR signaling pathway
hsa04151 PI3K-Akt signaling pathway
hsa04152 AMPK signaling pathway
hsa04210 Apoptosis
hsa04261 Adrenergic signaling in cardiomyocytes
hsa04370 VEGF signaling pathway
hsa04380 Osteoclast differentiation
hsa04510 Focal adhesion
hsa04550 Signaling pathways regulating pluripotency of stem cells
hsa04611 Platelet activation
hsa04620 Toll-like receptor signaling pathway
hsa04630 Jak-STAT signaling pathway
hsa04660 T cell receptor signaling pathway
hsa04662 B cell receptor signaling pathway
hsa04664 Fc epsilon RI signaling pathway
hsa04666 Fc gamma R-mediated phagocytosis
hsa04668 TNF signaling pathway
hsa04722 Neurotrophin signaling pathway
hsa04725 Cholinergic synapse
hsa04728 Dopaminergic synapse
hsa04910 Insulin signaling pathway
hsa04914 Progesterone-mediated oocyte maturation
hsa04915 Estrogen signaling pathway
hsa04917 Prolactin signaling pathway
hsa04919 Thyroid hormone signaling pathway
hsa04920 Adipocytokine signaling pathway
hsa04922 Glucagon signaling pathway
hsa04973 Carbohydrate digestion and absorption
Reactome R-HSA-198323: AKT phosphorylates targets in the cytosol
R-HSA-198693: AKT phosphorylates targets in the nucleus
R-HSA-211163: AKT-mediated inactivation of FOXO1A
R-HSA-111447: Activation of BAD and translocation to mitochondria
R-HSA-114452: Activation of BH3-only proteins
R-HSA-1280218: Adaptive Immune System
R-HSA-109581: Apoptosis
R-HSA-450385: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
R-HSA-389356: CD28 co-stimulation
R-HSA-389357: CD28 dependent PI3K/Akt signaling
R-HSA-389513: CTLA4 inhibitory signaling
R-HSA-1640170: Cell Cycle
R-HSA-69278: Cell Cycle, Mitotic
R-HSA-5674400: Constitutive Signaling by AKT1 E17K in Cancer
R-HSA-388841: Costimulation by the CD28 family
R-HSA-69202: Cyclin E associated events during G1/S transition
R-HSA-1280215: Cytokine Signaling in Immune system
R-HSA-2172127: DAP12 interactions
R-HSA-2424491: DAP12 signaling
R-HSA-3769402: Deactivation of the beta-catenin transactivating complex
R-HSA-1266738: Developmental Biology
R-HSA-1643685: Disease
R-HSA-5663202: Diseases of signal transduction
R-HSA-8863795: Downregulation of ERBB2 signaling
R-HSA-1358803: Downregulation of ERBB2
R-HSA-186763: Downstream signal transduction
R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR)
R-HSA-2454202: Fc epsilon receptor (FCERI) signaling
R-HSA-392451: G beta
R-HSA-397795: G-protein beta
R-HSA-69206: G1/S Transition
R-HSA-180292: GAB1 signalosome
R-HSA-388396: GPCR downstream signaling
R-HSA-114604: GPVI-mediated activation cascade
R-HSA-74160: Gene Expression
R-HSA-212436: Generic Transcription Pathway
R-HSA-109582: Hemostasis
R-HSA-2428924: IGF1R signaling cascade
R-HSA-112399: IRS-mediated signalling
R-HSA-2428928: IRS-related events triggered by IGF1R
R-HSA-168256: Immune System
R-HSA-168249: Innate Immune System
R-HSA-74751: Insulin receptor signalling cascade
R-HSA-354192: Integrin alphaIIb beta3 signaling
R-HSA-6785807: Interleukin-4 and 13 signaling
R-HSA-109606: Intrinsic Pathway for Apoptosis
R-HSA-450604: KSRP (KHSRP) binds and destabilizes mRNA
R-HSA-199991: Membrane Trafficking
R-HSA-1430728: Metabolism
R-HSA-202131: Metabolism of nitric oxide
R-HSA-453279: Mitotic G1-G1/S phases
R-HSA-187037: NGF signalling via TRKA from the plasma membrane
R-HSA-199418: Negative regulation of the PI3K/AKT network
R-HSA-109704: PI3K Cascade
R-HSA-2219528: PI3K/AKT Signaling in Cancer
R-HSA-198203: PI3K/AKT activation
R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-1257604: PIP3 activates AKT signaling
R-HSA-109703: PKB-mediated events
R-HSA-8849469: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
R-HSA-76009: Platelet Aggregation (Plug Formation)
R-HSA-76002: Platelet activation, signaling and aggregation
R-HSA-5357801: Programmed Cell Death
R-HSA-8876198: RAB GEFs exchange GTP for GDP on RABs
R-HSA-5633007: Regulation of TP53 Activity
R-HSA-6804758: Regulation of TP53 Activity through Acetylation
R-HSA-6804759: Regulation of TP53 Activity through Association with Co-factors
R-HSA-6804757: Regulation of TP53 Degradation
R-HSA-6806003: Regulation of TP53 Expression and Degradation
R-HSA-186712: Regulation of beta-cell development
R-HSA-210745: Regulation of gene expression in beta cells
R-HSA-450531: Regulation of mRNA stability by proteins that bind AU-rich elements
R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization
R-HSA-162582: Signal Transduction
R-HSA-177929: Signaling by EGFR
R-HSA-1227986: Signaling by ERBB2
R-HSA-372790: Signaling by GPCR
R-HSA-74752: Signaling by Insulin receptor
R-HSA-449147: Signaling by Interleukins
R-HSA-186797: Signaling by PDGF
R-HSA-8848021: Signaling by PTK6
R-HSA-1433557: Signaling by SCF-KIT
R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
R-HSA-194138: Signaling by VEGF
R-HSA-195721: Signaling by Wnt
R-HSA-983705: Signaling by the B Cell Receptor (BCR)
R-HSA-166520: Signalling by NGF
R-HSA-201681: TCF dependent signaling in response to WNT
R-HSA-5628897: TP53 Regulates Metabolic Genes
R-HSA-1474151: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
R-HSA-3700989: Transcriptional Regulation by TP53
R-HSA-1445148: Translocation of GLUT4 to the plasma membrane
R-HSA-4420097: VEGFA-VEGFR2 Pathway
R-HSA-5218920: VEGFR2 mediated vascular permeability
R-HSA-5653656: Vesicle-mediated transport
R-HSA-203615: eNOS activation
R-HSA-203765: eNOS activation and regulation
R-HSA-165159: mTOR signalling
Summary
SymbolAKT1
Namev-akt murine thymoma viral oncogene homolog 1
Aliases RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ......
Chromosomal Location14q32.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between AKT1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between AKT1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
26637667Lung CarcinomaInhibit immunity (T cell function)AKT These data suggest that oncogenic activation of the AKT-mTOR pathway promotes immune escape by driving expression of PD-L1, which was confirmed in syngeneic and genetically engineered mouse models of lung cancer where an mTOR inhibitor combined with a PD-1 antibody decreased tumor growth, increased tumor-infiltrating T cells, and decreased regulatory T cells.
26921343Lung CarcinomaPromote immunity (infiltration and T cell function)Here, we used viable human lung tumor slices and autologous tumor antigen-specific T-lymphocyte clones to provide evidence that CD103 is directly involved in T-lymphocyte recruitment within epithelial tumor islets and intratumoral early T-cell signaling. Mechanistic investigations revealed that TGFβ bound to its receptors (TGFBR), which promoted the recruitment and phosphorylation of integrin-linked kinase (ILK) by TGFBR1. We further show that ILK interacted with the CD103 intracellular domain, resulting in protein kinase B (PKB)/AKT activation, thereby initiating integrin inside-out signaling.
25589622E7+ tumor TC-1Inhibit immunity (T cell function)Gain of HIF-1α under normoxia in cancer mediates immune adaptation through the AKT/ERK and VEGFA axes. We found that tumor cells gain HIF-1α in the course of immune selection under normoxia and that HIF-1α renders tumor cells resistant to lysis by tumor-specific cytotoxic T lymphocytes (CTL) in culture and in mice.
25548153MelanomaPromote immunity (T cell function)Expression of constitutively active Stat5a recapitulated the survival advantages conferred by miR-155, whereas constitutive Akt activation promoted sustained effector functions. Our results indicate that overexpression of miR-155 in tumor-specific T cells can be used to increase the effectiveness of adoptive immunotherapies in a cell-intrinsic manner without the need for life-threatening, lymphodepleting maneuvers.
25432172MelanomaInhibit immunity (T cell function)Consequently, Akt inhibition results in enhanced persistence of TIL after adoptive transfer into an immunodeficient animal model and augments antitumor immunity of CD8 T cells in a mouse model of cell-based immunotherapy.
25336630Plasma Cell MyelomaInhibit immunity (T cell function)Akt Inhibition of Akt signaling promotes the generation of superior tumor-reactive T cells for adoptive immunotherapy.
28478231Non-Small Cell Lung CarcinomaInhibit immunity (T cell function)Radiotherapy may up-regulate PD-L1 expression through the phosphoinositide 3-kinase/AKT and signal transducer and activator of transcription 3 pathways.
27550451Lung CarcinomaInhibit immunity (T cell function)In particular, we found that IL34 modulated the functions of tumor-associated macrophages to enhance local immunosuppression and to promote the survival of chemoresistant cancer cells by activating AKT signaling. Targeting IL34 in chemoresistant tumors resulted in a remarkable inhibition of tumor growth when accompanied with chemotherapy.
19107122MyelomaInhibit immunity (T cell function)Retroviral transfer of a constitutively active form of Akt into the parental tumor significantly increased its resistance against E7-specific CD8(+) T-cell mediated apoptosis. The observed resistance against apoptosis was found to be associated with the upregulation of antiapoptotic molecules.
24892809biliary atresiaInhibit immunityInduction of the IL-33/ILC2/IL-13 circuit in a murine biliary injury model promoted epithelial repair; however, induction of this circuit in mice with constitutive activation of AKT and YAP in bile ducts induced cholangiocarcinoma with liver metastases.
27863995MelanomaInhibit immunityTo effectively treat this aggressive tumor, a multi-target receptor tyrosine kinase inhibitor, sunitinib base, was efficiently encapsulated into a targeted polymeric micelle nano-delivery system (SUNb-PM), working in a synergistic manner with vaccine therapy in an advanced mouse melanoma model. Inhibition of the Stat3 and AKT signaling pathways by SUNb-PM may induce tumor cell apoptosis or decrease tumor immune evasion.
21441454MelanomaInhibit immunityInteraction of LAG-3 with MHC II expressed on melanoma cells upregulates both MAPK/Erk and PI3K/Akt pathways, albeit with different kinetics. Inhibition studies using specific inhibitors of both pathways provided evidence of their involvement in the LAG-3-induced protection from apoptosis.
28615225MelanomaInhibit immunityInhibition of specific Akt isoforms in CD8+T cells promotes favored differentiation into memory versus effector cells, the former of which are superior in mediating antitumor immunity. This effect was preserved in vivo after ex vivo PI3K-δ inhibition in CD8+ T cells destined for adoptive transfer, enhancing their survival and also the antitumor therapeutic activity of a tumor-specific peptide vaccine.
24469034Squamous Cell CarcinomaInhibit immunityThus, tumors may arise in these mice as a result of the increased cell survival induced by Akt activation triggered by loss of αv and p53, and by the defective recruitment of immune cells to these tumors, which may allow immune evasion.
20395201Lung CarcinomaInhibit immunityFurthermore, the retroviral transduction of XLR in parental tumor cells led to activation of Akt, resulting in upregulation of antiapoptotic proteins and the induction of immune resistance phenotype in parental tumor cells.
25080445Melanoma; Colon Carcinoma; LymphomaInhibit immunityFurthermore, these PI3K-Akt inhibitors led to a significant therapeutic antitumor effect, which was shown to be Treg dependent. Here, we report the use of PI3K-Akt pathway inhibitors as potent agents for the selective depletion of suppressive Tregs. We found that PI3K-Akt pathway inhibitors selectively inhibit Tregs with minimal effect on conventional T cells
Summary
SymbolAKT1
Namev-akt murine thymoma viral oncogene homolog 1
Aliases RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ......
Chromosomal Location14q32.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of AKT1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NS NA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell logFC: -2.04; FDR: 0.04110 Resistant to T cell-mediated killing
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NS NA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NS NA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NS NA/NS
24476824shRNAmelanomaB16Primary screen NA/NS NA/NS
24476824shRNAmelanomaB16Secondary screen NA/NS NA/NS
Summary
SymbolAKT1
Namev-akt murine thymoma viral oncogene homolog 1
Aliases RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ......
Chromosomal Location14q32.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of AKT1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.1140.65
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.0380.989
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.2260.913
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.3910.313
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590.2620.916
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5570.864
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.0420.924
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.060.976
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.1620.941
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.4880.789
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.1410.67
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.0130.822
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of AKT1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.42.74.70.294
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.43.440.587
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21170001
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13110001
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38272.602.61
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16146.206.21
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolAKT1
Namev-akt murine thymoma viral oncogene homolog 1
Aliases RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ......
Chromosomal Location14q32.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AKT1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolAKT1
Namev-akt murine thymoma viral oncogene homolog 1
Aliases RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ......
Chromosomal Location14q32.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AKT1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AKT1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolAKT1
Namev-akt murine thymoma viral oncogene homolog 1
Aliases RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ......
Chromosomal Location14q32.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AKT1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolAKT1
Namev-akt murine thymoma viral oncogene homolog 1
Aliases RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ......
Chromosomal Location14q32.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of AKT1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolAKT1
Namev-akt murine thymoma viral oncogene homolog 1
Aliases RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ......
Chromosomal Location14q32.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between AKT1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolAKT1
Namev-akt murine thymoma viral oncogene homolog 1
Aliases RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ......
Chromosomal Location14q32.33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting AKT1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting AKT1.
ID Name Drug Type Targets #Targets
DB00171ATPSmall MoleculeABCA1, ABCB1, ABCB11, ABCC1, ABCC2, ABCC4, ABCC6, ABCC8, ABCC9, AB ......42
DB01169Arsenic trioxideSmall MoleculeAKT1, CCND1, CDKN1A, HDAC1, IKBKB, JUN, MAPK1, MAPK3, PML, TXNRD110
DB01645GenisteinSmall MoleculeAKT1, CYP1B1, ESR1, ESR2, ESRRA, ESRRB, GPER1, NCOA1, NCOA2, NR1I2 ......13
DB01863Inositol 1,3,4,5-TetrakisphosphateSmall MoleculeAKT1, BTK, CYTH2, CYTH3, DAPP1, ITPKA, PDPK1, PLEKHA48
DB02709ResveratrolSmall MoleculeAHR, AKT1, ALOX15, ALOX5, APP, CBR1, CLEC14A, CSNK2A1, ESR1, ITGA5 ......25
DB05971ArchexinSmall MoleculeAKT11
DB06486EnzastaurinSmall MoleculeAKT1, AURKA, AURKB, CDK15, CHEK1, CHEK2, PIK3R1, PRKCB8
DB06641PerifosineSmall MoleculeAKT1, MAPK1, PRKCA3
DB07584N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amineSmall MoleculeAKT1, GSK3B2
DB075855-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridineSmall MoleculeAKT1, GSK3B2