Summary | |
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Symbol | AKT1 |
Name | v-akt murine thymoma viral oncogene homolog 1 |
Aliases | RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ...... |
Chromosomal Location | 14q32.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. Nucleus. Cell membrane. Note=Nucleus after activation by integrin-linked protein kinase 1 (ILK1). Nuclear translocation is enhanced by interaction with TCL1A. Phosphorylation on Tyr-176 by TNK2 results in its localization to the cell membrane where it is targeted for further phosphorylations on Thr-308 and Ser-473 leading to its activation and the activated form translocates to the nucleus. Colocalizes with WDFY2 in intracellular vesicles (PubMed:16792529). |
Domain |
PF00169 PH domain PF00069 Protein kinase domain PF00433 Protein kinase C terminal domain |
Function |
AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at 'Ser-9', resulting in inhibition of its kinase activity. Phosphorylation of GSK3 isoforms by AKT is also thought to be one mechanism by which cell proliferation is driven. AKT regulates also cell survival via the phosphorylation of MAP3K5 (apoptosis signal-related kinase). Phosphorylation of 'Ser-83' decreases MAP3K5 kinase activity stimulated by oxidative stress and thereby prevents apoptosis. AKT mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is involved in the phosphorylation of members of the FOXO factors (Forkhead family of transcription factors), leading to binding of 14-3-3 proteins and cytoplasmic localization. In particular, FOXO1 is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and FOXO4 are phosphorylated on equivalent sites. AKT has an important role in the regulation of NF-kappa-B-dependent gene transcription and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-response element binding protein). The phosphorylation of CREB1 induces the binding of accessory proteins that are necessary for the transcription of pro-survival genes such as BCL2 and MCL1. AKT phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby potentially regulating ACLY activity and fatty acid synthesis. Activates the 3B isoform of cyclic nucleotide phosphodiesterase (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced cyclic AMP levels and inhibition of lipolysis. Phosphorylates PIKFYVE on 'Ser-318', which results in increased PI(3)P-5 activity. The Rho GTPase-activating protein DLC1 is another substrate and its phosphorylation is implicated in the regulation cell proliferation and cell growth. AKT plays a role as key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). AKT mediates the antiapoptotic effects of IGF-I. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. May be involved in the regulation of the placental development. Phosphorylates STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its: kinase activity, nuclear translocation, autophosphorylation and ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-117' and 'Thr-384' leading to inhibition of its: cleavage, kinase activity, autophosphorylation at Thr-180, binding to RASSF1 and nuclear translocation. Phosphorylates SRPK2 and enhances its kinase activity towards SRSF2 and ACIN1 and promotes its nuclear translocation. Phosphorylates RAF1 at 'Ser-259' and negatively regulates its activity. Phosphorylation of BAD stimulates its pro-apoptotic activity. Phosphorylates KAT6A at 'Thr-369' and this phosphorylation inhibits the interaction of KAT6A with PML and negatively regulates its acetylation activity towards p53/TP53.; FUNCTION: AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation. |
Biological Process |
GO:0000060 protein import into nucleus, translocation GO:0000075 cell cycle checkpoint GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity GO:0000082 G1/S transition of mitotic cell cycle GO:0000271 polysaccharide biosynthetic process GO:0001503 ossification GO:0001558 regulation of cell growth GO:0001649 osteoblast differentiation GO:0001666 response to hypoxia GO:0001667 ameboidal-type cell migration GO:0001701 in utero embryonic development GO:0001776 leukocyte homeostasis GO:0001836 release of cytochrome c from mitochondria GO:0001890 placenta development GO:0001892 embryonic placenta development GO:0001893 maternal placenta development GO:0001933 negative regulation of protein phosphorylation GO:0001935 endothelial cell proliferation GO:0001936 regulation of endothelial cell proliferation GO:0001938 positive regulation of endothelial cell proliferation GO:0002028 regulation of sodium ion transport GO:0002237 response to molecule of bacterial origin GO:0002260 lymphocyte homeostasis GO:0002694 regulation of leukocyte activation GO:0002696 positive regulation of leukocyte activation GO:0003013 circulatory system process GO:0003018 vascular process in circulatory system GO:0005976 polysaccharide metabolic process GO:0005977 glycogen metabolic process GO:0005978 glycogen biosynthetic process GO:0005979 regulation of glycogen biosynthetic process GO:0005996 monosaccharide metabolic process GO:0006006 glucose metabolic process GO:0006022 aminoglycan metabolic process GO:0006073 cellular glucan metabolic process GO:0006091 generation of precursor metabolites and energy GO:0006109 regulation of carbohydrate metabolic process GO:0006112 energy reserve metabolic process GO:0006417 regulation of translation GO:0006469 negative regulation of protein kinase activity GO:0006606 protein import into nucleus GO:0006631 fatty acid metabolic process GO:0006635 fatty acid beta-oxidation GO:0006809 nitric oxide biosynthetic process GO:0006814 sodium ion transport GO:0006820 anion transport GO:0006869 lipid transport GO:0006913 nucleocytoplasmic transport GO:0006914 autophagy GO:0006924 activation-induced cell death of T cells GO:0006979 response to oxidative stress GO:0007009 plasma membrane organization GO:0007159 leukocyte cell-cell adhesion GO:0007173 epidermal growth factor receptor signaling pathway GO:0007254 JNK cascade GO:0007272 ensheathment of neurons GO:0007281 germ cell development GO:0007346 regulation of mitotic cell cycle GO:0007422 peripheral nervous system development GO:0007565 female pregnancy GO:0007568 aging GO:0007596 blood coagulation GO:0007599 hemostasis GO:0008015 blood circulation GO:0008286 insulin receptor signaling pathway GO:0008361 regulation of cell size GO:0008366 axon ensheathment GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008637 apoptotic mitochondrial changes GO:0008643 carbohydrate transport GO:0008645 hexose transport GO:0009062 fatty acid catabolic process GO:0009250 glucan biosynthetic process GO:0009266 response to temperature stimulus GO:0009314 response to radiation GO:0009408 response to heat GO:0009411 response to UV GO:0009416 response to light stimulus GO:0009612 response to mechanical stimulus GO:0009894 regulation of catabolic process GO:0009895 negative regulation of catabolic process GO:0009896 positive regulation of catabolic process GO:0009991 response to extracellular stimulus GO:0010001 glial cell differentiation GO:0010466 negative regulation of peptidase activity GO:0010498 proteasomal protein catabolic process GO:0010506 regulation of autophagy GO:0010507 negative regulation of autophagy GO:0010565 regulation of cellular ketone metabolic process GO:0010594 regulation of endothelial cell migration GO:0010595 positive regulation of endothelial cell migration GO:0010608 posttranscriptional regulation of gene expression GO:0010631 epithelial cell migration GO:0010632 regulation of epithelial cell migration GO:0010634 positive regulation of epithelial cell migration GO:0010639 negative regulation of organelle organization GO:0010675 regulation of cellular carbohydrate metabolic process GO:0010676 positive regulation of cellular carbohydrate metabolic process GO:0010746 regulation of plasma membrane long-chain fatty acid transport GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport GO:0010761 fibroblast migration GO:0010762 regulation of fibroblast migration GO:0010763 positive regulation of fibroblast migration GO:0010765 positive regulation of sodium ion transport GO:0010821 regulation of mitochondrion organization GO:0010823 negative regulation of mitochondrion organization GO:0010827 regulation of glucose transport GO:0010828 positive regulation of glucose transport GO:0010876 lipid localization GO:0010906 regulation of glucose metabolic process GO:0010907 positive regulation of glucose metabolic process GO:0010951 negative regulation of endopeptidase activity GO:0010959 regulation of metal ion transport GO:0010962 regulation of glucan biosynthetic process GO:0010975 regulation of neuron projection development GO:0014037 Schwann cell differentiation GO:0014044 Schwann cell development GO:0014065 phosphatidylinositol 3-kinase signaling GO:0014066 regulation of phosphatidylinositol 3-kinase signaling GO:0015672 monovalent inorganic cation transport GO:0015711 organic anion transport GO:0015718 monocarboxylic acid transport GO:0015749 monosaccharide transport GO:0015758 glucose transport GO:0015849 organic acid transport GO:0015908 fatty acid transport GO:0015909 long-chain fatty acid transport GO:0015911 plasma membrane long-chain fatty acid transport GO:0015980 energy derivation by oxidation of organic compounds GO:0016042 lipid catabolic process GO:0016049 cell growth GO:0016051 carbohydrate biosynthetic process GO:0016054 organic acid catabolic process GO:0017038 protein import GO:0018105 peptidyl-serine phosphorylation GO:0018107 peptidyl-threonine phosphorylation GO:0018209 peptidyl-serine modification GO:0018210 peptidyl-threonine modification GO:0019216 regulation of lipid metabolic process GO:0019217 regulation of fatty acid metabolic process GO:0019229 regulation of vasoconstriction GO:0019318 hexose metabolic process GO:0019395 fatty acid oxidation GO:0021510 spinal cord development GO:0021782 glial cell development GO:0022011 myelination in peripheral nervous system GO:0022407 regulation of cell-cell adhesion GO:0022409 positive regulation of cell-cell adhesion GO:0022412 cellular process involved in reproduction in multicellular organism GO:0030168 platelet activation GO:0030203 glycosaminoglycan metabolic process GO:0030212 hyaluronan metabolic process GO:0030258 lipid modification GO:0030307 positive regulation of cell growth GO:0030335 positive regulation of cell migration GO:0030879 mammary gland development GO:0031016 pancreas development GO:0031018 endocrine pancreas development GO:0031098 stress-activated protein kinase signaling cascade GO:0031294 lymphocyte costimulation GO:0031295 T cell costimulation GO:0031329 regulation of cellular catabolic process GO:0031330 negative regulation of cellular catabolic process GO:0031331 positive regulation of cellular catabolic process GO:0031641 regulation of myelination GO:0031657 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031663 lipopolysaccharide-mediated signaling pathway GO:0031667 response to nutrient levels GO:0031998 regulation of fatty acid beta-oxidation GO:0031999 negative regulation of fatty acid beta-oxidation GO:0032069 regulation of nuclease activity GO:0032070 regulation of deoxyribonuclease activity GO:0032071 regulation of endodeoxyribonuclease activity GO:0032075 positive regulation of nuclease activity GO:0032077 positive regulation of deoxyribonuclease activity GO:0032079 positive regulation of endodeoxyribonuclease activity GO:0032094 response to food GO:0032287 peripheral nervous system myelin maintenance GO:0032292 peripheral nervous system axon ensheathment GO:0032368 regulation of lipid transport GO:0032369 negative regulation of lipid transport GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032496 response to lipopolysaccharide GO:0032507 maintenance of protein location in cell GO:0032535 regulation of cellular component size GO:0032768 regulation of monooxygenase activity GO:0032770 positive regulation of monooxygenase activity GO:0032868 response to insulin GO:0032869 cellular response to insulin stimulus GO:0032872 regulation of stress-activated MAPK cascade GO:0032873 negative regulation of stress-activated MAPK cascade GO:0032881 regulation of polysaccharide metabolic process GO:0032885 regulation of polysaccharide biosynthetic process GO:0032890 regulation of organic acid transport GO:0032891 negative regulation of organic acid transport GO:0033002 muscle cell proliferation GO:0033135 regulation of peptidyl-serine phosphorylation GO:0033138 positive regulation of peptidyl-serine phosphorylation GO:0033500 carbohydrate homeostasis GO:0033673 negative regulation of kinase activity GO:0033674 positive regulation of kinase activity GO:0033692 cellular polysaccharide biosynthetic process GO:0034248 regulation of cellular amide metabolic process GO:0034405 response to fluid shear stress GO:0034440 lipid oxidation GO:0034504 protein localization to nucleus GO:0034599 cellular response to oxidative stress GO:0034637 cellular carbohydrate biosynthetic process GO:0034694 response to prostaglandin GO:0034695 response to prostaglandin E GO:0034762 regulation of transmembrane transport GO:0034763 negative regulation of transmembrane transport GO:0034765 regulation of ion transmembrane transport GO:0034766 negative regulation of ion transmembrane transport GO:0035150 regulation of tube size GO:0035270 endocrine system development GO:0035655 interleukin-18-mediated signaling pathway GO:0035924 cellular response to vascular endothelial growth factor stimulus GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0036473 cell death in response to oxidative stress GO:0038034 signal transduction in absence of ligand GO:0038127 ERBB signaling pathway GO:0038128 ERBB2 signaling pathway GO:0040017 positive regulation of locomotion GO:0042058 regulation of epidermal growth factor receptor signaling pathway GO:0042063 gliogenesis GO:0042110 T cell activation GO:0042176 regulation of protein catabolic process GO:0042180 cellular ketone metabolic process GO:0042310 vasoconstriction GO:0042326 negative regulation of phosphorylation GO:0042552 myelination GO:0042593 glucose homeostasis GO:0042692 muscle cell differentiation GO:0043029 T cell homeostasis GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process GO:0043217 myelin maintenance GO:0043255 regulation of carbohydrate biosynthetic process GO:0043270 positive regulation of ion transport GO:0043271 negative regulation of ion transport GO:0043281 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043409 negative regulation of MAPK cascade GO:0043434 response to peptide hormone GO:0043467 regulation of generation of precursor metabolites and energy GO:0043487 regulation of RNA stability GO:0043488 regulation of mRNA stability GO:0043491 protein kinase B signaling GO:0043534 blood vessel endothelial cell migration GO:0043535 regulation of blood vessel endothelial cell migration GO:0043536 positive regulation of blood vessel endothelial cell migration GO:0043542 endothelial cell migration GO:0044042 glucan metabolic process GO:0044057 regulation of system process GO:0044070 regulation of anion transport GO:0044242 cellular lipid catabolic process GO:0044262 cellular carbohydrate metabolic process GO:0044264 cellular polysaccharide metabolic process GO:0044282 small molecule catabolic process GO:0044706 multi-multicellular organism process GO:0044723 single-organism carbohydrate metabolic process GO:0044744 protein targeting to nucleus GO:0044770 cell cycle phase transition GO:0044772 mitotic cell cycle phase transition GO:0044843 cell cycle G1/S phase transition GO:0045185 maintenance of protein location GO:0045428 regulation of nitric oxide biosynthetic process GO:0045429 positive regulation of nitric oxide biosynthetic process GO:0045444 fat cell differentiation GO:0045598 regulation of fat cell differentiation GO:0045600 positive regulation of fat cell differentiation GO:0045725 positive regulation of glycogen biosynthetic process GO:0045732 positive regulation of protein catabolic process GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway GO:0045785 positive regulation of cell adhesion GO:0045787 positive regulation of cell cycle GO:0045792 negative regulation of cell size GO:0045833 negative regulation of lipid metabolic process GO:0045834 positive regulation of lipid metabolic process GO:0045860 positive regulation of protein kinase activity GO:0045861 negative regulation of proteolysis GO:0045862 positive regulation of proteolysis GO:0045907 positive regulation of vasoconstriction GO:0045913 positive regulation of carbohydrate metabolic process GO:0045922 negative regulation of fatty acid metabolic process GO:0045927 positive regulation of growth GO:0046209 nitric oxide metabolic process GO:0046320 regulation of fatty acid oxidation GO:0046322 negative regulation of fatty acid oxidation GO:0046323 glucose import GO:0046324 regulation of glucose import GO:0046326 positive regulation of glucose import GO:0046328 regulation of JNK cascade GO:0046329 negative regulation of JNK cascade GO:0046395 carboxylic acid catabolic process GO:0046777 protein autophosphorylation GO:0046889 positive regulation of lipid biosynthetic process GO:0046890 regulation of lipid biosynthetic process GO:0046942 carboxylic acid transport GO:0048009 insulin-like growth factor receptor signaling pathway GO:0048015 phosphatidylinositol-mediated signaling GO:0048017 inositol lipid-mediated signaling GO:0048568 embryonic organ development GO:0048608 reproductive structure development GO:0048659 smooth muscle cell proliferation GO:0048660 regulation of smooth muscle cell proliferation GO:0048661 positive regulation of smooth muscle cell proliferation GO:0048732 gland development GO:0048872 homeostasis of number of cells GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0050679 positive regulation of epithelial cell proliferation GO:0050817 coagulation GO:0050863 regulation of T cell activation GO:0050865 regulation of cell activation GO:0050867 positive regulation of cell activation GO:0050870 positive regulation of T cell activation GO:0050878 regulation of body fluid levels GO:0050880 regulation of blood vessel size GO:0050994 regulation of lipid catabolic process GO:0050995 negative regulation of lipid catabolic process GO:0050999 regulation of nitric-oxide synthase activity GO:0051000 positive regulation of nitric-oxide synthase activity GO:0051051 negative regulation of transport GO:0051052 regulation of DNA metabolic process GO:0051054 positive regulation of DNA metabolic process GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051146 striated muscle cell differentiation GO:0051169 nuclear transport GO:0051170 nuclear import GO:0051220 cytoplasmic sequestering of protein GO:0051235 maintenance of location GO:0051249 regulation of lymphocyte activation GO:0051251 positive regulation of lymphocyte activation GO:0051272 positive regulation of cellular component movement GO:0051341 regulation of oxidoreductase activity GO:0051346 negative regulation of hydrolase activity GO:0051348 negative regulation of transferase activity GO:0051353 positive regulation of oxidoreductase activity GO:0051403 stress-activated MAPK cascade GO:0051651 maintenance of location in cell GO:0052547 regulation of peptidase activity GO:0052548 regulation of endopeptidase activity GO:0060135 maternal process involved in female pregnancy GO:0060416 response to growth hormone GO:0060644 mammary gland epithelial cell differentiation GO:0060674 placenta blood vessel development GO:0060706 cell differentiation involved in embryonic placenta development GO:0060709 glycogen cell differentiation involved in embryonic placenta development GO:0060711 labyrinthine layer development GO:0060712 spongiotrophoblast layer development GO:0060716 labyrinthine layer blood vessel development GO:0061136 regulation of proteasomal protein catabolic process GO:0061180 mammary gland epithelium development GO:0061458 reproductive system development GO:0070141 response to UV-A GO:0070227 lymphocyte apoptotic process GO:0070231 T cell apoptotic process GO:0070302 regulation of stress-activated protein kinase signaling cascade GO:0070303 negative regulation of stress-activated protein kinase signaling cascade GO:0070482 response to oxygen levels GO:0070486 leukocyte aggregation GO:0070489 T cell aggregation GO:0070585 protein localization to mitochondrion GO:0070673 response to interleukin-18 GO:0070849 response to epidermal growth factor GO:0070873 regulation of glycogen metabolic process GO:0070875 positive regulation of glycogen metabolic process GO:0070997 neuron death GO:0071214 cellular response to abiotic stimulus GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071260 cellular response to mechanical stimulus GO:0071351 cellular response to interleukin-18 GO:0071364 cellular response to epidermal growth factor stimulus GO:0071375 cellular response to peptide hormone stimulus GO:0071379 cellular response to prostaglandin stimulus GO:0071380 cellular response to prostaglandin E stimulus GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071417 cellular response to organonitrogen compound GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0071496 cellular response to external stimulus GO:0071593 lymphocyte aggregation GO:0071887 leukocyte apoptotic process GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity GO:0072329 monocarboxylic acid catabolic process GO:0072331 signal transduction by p53 class mediator GO:0072593 reactive oxygen species metabolic process GO:0072595 maintenance of protein localization in organelle GO:0072655 establishment of protein localization to mitochondrion GO:0072656 maintenance of protein location in mitochondrion GO:0072657 protein localization to membrane GO:0072659 protein localization to plasma membrane GO:0090002 establishment of protein localization to plasma membrane GO:0090003 regulation of establishment of protein localization to plasma membrane GO:0090004 positive regulation of establishment of protein localization to plasma membrane GO:0090066 regulation of anatomical structure size GO:0090130 tissue migration GO:0090132 epithelium migration GO:0090150 establishment of protein localization to membrane GO:0090199 regulation of release of cytochrome c from mitochondria GO:0090201 negative regulation of release of cytochrome c from mitochondria GO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus GO:0097012 response to granulocyte macrophage colony-stimulating factor GO:0097191 extrinsic apoptotic signaling pathway GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand GO:0097193 intrinsic apoptotic signaling pathway GO:0097194 execution phase of apoptosis GO:0098656 anion transmembrane transport GO:0099565 chemical synaptic transmission, postsynaptic GO:0100002 negative regulation of protein kinase activity by protein phosphorylation GO:1900180 regulation of protein localization to nucleus GO:1900182 positive regulation of protein localization to nucleus GO:1900407 regulation of cellular response to oxidative stress GO:1900408 negative regulation of cellular response to oxidative stress GO:1901099 negative regulation of signal transduction in absence of ligand GO:1901184 regulation of ERBB signaling pathway GO:1901186 positive regulation of ERBB signaling pathway GO:1901214 regulation of neuron death GO:1901215 negative regulation of neuron death GO:1901652 response to peptide GO:1901653 cellular response to peptide GO:1901654 response to ketone GO:1901655 cellular response to ketone GO:1901796 regulation of signal transduction by p53 class mediator GO:1901800 positive regulation of proteasomal protein catabolic process GO:1901976 regulation of cell cycle checkpoint GO:1901987 regulation of cell cycle phase transition GO:1901990 regulation of mitotic cell cycle phase transition GO:1902001 fatty acid transmembrane transport GO:1902175 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902176 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway GO:1902532 negative regulation of intracellular signal transduction GO:1902593 single-organism nuclear import GO:1902806 regulation of cell cycle G1/S phase transition GO:1902882 regulation of response to oxidative stress GO:1902883 negative regulation of response to oxidative stress GO:1903037 regulation of leukocyte cell-cell adhesion GO:1903039 positive regulation of leukocyte cell-cell adhesion GO:1903050 regulation of proteolysis involved in cellular protein catabolic process GO:1903052 positive regulation of proteolysis involved in cellular protein catabolic process GO:1903076 regulation of protein localization to plasma membrane GO:1903078 positive regulation of protein localization to plasma membrane GO:1903201 regulation of oxidative stress-induced cell death GO:1903202 negative regulation of oxidative stress-induced cell death GO:1903362 regulation of cellular protein catabolic process GO:1903364 positive regulation of cellular protein catabolic process GO:1903409 reactive oxygen species biosynthetic process GO:1903426 regulation of reactive oxygen species biosynthetic process GO:1903428 positive regulation of reactive oxygen species biosynthetic process GO:1903510 mucopolysaccharide metabolic process GO:1903522 regulation of blood circulation GO:1903524 positive regulation of blood circulation GO:1903729 regulation of plasma membrane organization GO:1903792 negative regulation of anion transport GO:1903825 organic acid transmembrane transport GO:1903829 positive regulation of cellular protein localization GO:1903959 regulation of anion transmembrane transport GO:1903960 negative regulation of anion transmembrane transport GO:1904029 regulation of cyclin-dependent protein kinase activity GO:1904031 positive regulation of cyclin-dependent protein kinase activity GO:1904375 regulation of protein localization to cell periphery GO:1904377 positive regulation of protein localization to cell periphery GO:1904407 positive regulation of nitric oxide metabolic process GO:1904951 positive regulation of establishment of protein localization GO:1905039 carboxylic acid transmembrane transport GO:1990089 response to nerve growth factor GO:1990090 cellular response to nerve growth factor stimulus GO:1990418 response to insulin-like growth factor stimulus GO:1990778 protein localization to cell periphery GO:2000045 regulation of G1/S transition of mitotic cell cycle GO:2000116 regulation of cysteine-type endopeptidase activity GO:2000117 negative regulation of cysteine-type endopeptidase activity GO:2000147 positive regulation of cell motility GO:2000191 regulation of fatty acid transport GO:2000192 negative regulation of fatty acid transport GO:2000377 regulation of reactive oxygen species metabolic process GO:2000379 positive regulation of reactive oxygen species metabolic process GO:2001057 reactive nitrogen species metabolic process GO:2001233 regulation of apoptotic signaling pathway GO:2001234 negative regulation of apoptotic signaling pathway GO:2001236 regulation of extrinsic apoptotic signaling pathway GO:2001237 negative regulation of extrinsic apoptotic signaling pathway GO:2001239 regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001242 regulation of intrinsic apoptotic signaling pathway GO:2001243 negative regulation of intrinsic apoptotic signaling pathway |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004712 protein serine/threonine/tyrosine kinase activity GO:0005080 protein kinase C binding GO:0005543 phospholipid binding GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding GO:0019902 phosphatase binding GO:0019903 protein phosphatase binding GO:0030235 nitric-oxide synthase regulator activity GO:0032794 GTPase activating protein binding GO:0035091 phosphatidylinositol binding GO:0043168 anion binding GO:0043325 phosphatidylinositol-3,4-bisphosphate binding GO:0051721 protein phosphatase 2A binding GO:0071889 14-3-3 protein binding GO:1901981 phosphatidylinositol phosphate binding |
Cellular Component |
GO:0005819 spindle GO:0005929 cilium GO:0036064 ciliary basal body GO:0044441 ciliary part GO:0098794 postsynapse |
KEGG |
hsa04010 MAPK signaling pathway hsa04012 ErbB signaling pathway hsa04014 Ras signaling pathway hsa04015 Rap1 signaling pathway hsa04022 cGMP-PKG signaling pathway hsa04024 cAMP signaling pathway hsa04062 Chemokine signaling pathway hsa04066 HIF-1 signaling pathway hsa04068 FoxO signaling pathway hsa04071 Sphingolipid signaling pathway hsa04140 Regulation of autophagy hsa04150 mTOR signaling pathway hsa04151 PI3K-Akt signaling pathway hsa04152 AMPK signaling pathway hsa04210 Apoptosis hsa04261 Adrenergic signaling in cardiomyocytes hsa04370 VEGF signaling pathway hsa04380 Osteoclast differentiation hsa04510 Focal adhesion hsa04550 Signaling pathways regulating pluripotency of stem cells hsa04611 Platelet activation hsa04620 Toll-like receptor signaling pathway hsa04630 Jak-STAT signaling pathway hsa04660 T cell receptor signaling pathway hsa04662 B cell receptor signaling pathway hsa04664 Fc epsilon RI signaling pathway hsa04666 Fc gamma R-mediated phagocytosis hsa04668 TNF signaling pathway hsa04722 Neurotrophin signaling pathway hsa04725 Cholinergic synapse hsa04728 Dopaminergic synapse hsa04910 Insulin signaling pathway hsa04914 Progesterone-mediated oocyte maturation hsa04915 Estrogen signaling pathway hsa04917 Prolactin signaling pathway hsa04919 Thyroid hormone signaling pathway hsa04920 Adipocytokine signaling pathway hsa04922 Glucagon signaling pathway hsa04973 Carbohydrate digestion and absorption |
Reactome |
R-HSA-198323: AKT phosphorylates targets in the cytosol R-HSA-198693: AKT phosphorylates targets in the nucleus R-HSA-211163: AKT-mediated inactivation of FOXO1A R-HSA-111447: Activation of BAD and translocation to mitochondria R-HSA-114452: Activation of BH3-only proteins R-HSA-1280218: Adaptive Immune System R-HSA-109581: Apoptosis R-HSA-450385: Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA R-HSA-389356: CD28 co-stimulation R-HSA-389357: CD28 dependent PI3K/Akt signaling R-HSA-389513: CTLA4 inhibitory signaling R-HSA-1640170: Cell Cycle R-HSA-69278: Cell Cycle, Mitotic R-HSA-5674400: Constitutive Signaling by AKT1 E17K in Cancer R-HSA-388841: Costimulation by the CD28 family R-HSA-69202: Cyclin E associated events during G1/S transition R-HSA-1280215: Cytokine Signaling in Immune system R-HSA-2172127: DAP12 interactions R-HSA-2424491: DAP12 signaling R-HSA-3769402: Deactivation of the beta-catenin transactivating complex R-HSA-1266738: Developmental Biology R-HSA-1643685: Disease R-HSA-5663202: Diseases of signal transduction R-HSA-8863795: Downregulation of ERBB2 signaling R-HSA-1358803: Downregulation of ERBB2 R-HSA-186763: Downstream signal transduction R-HSA-1168372: Downstream signaling events of B Cell Receptor (BCR) R-HSA-2454202: Fc epsilon receptor (FCERI) signaling R-HSA-392451: G beta R-HSA-397795: G-protein beta R-HSA-69206: G1/S Transition R-HSA-180292: GAB1 signalosome R-HSA-388396: GPCR downstream signaling R-HSA-114604: GPVI-mediated activation cascade R-HSA-74160: Gene Expression R-HSA-212436: Generic Transcription Pathway R-HSA-109582: Hemostasis R-HSA-2428924: IGF1R signaling cascade R-HSA-112399: IRS-mediated signalling R-HSA-2428928: IRS-related events triggered by IGF1R R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-74751: Insulin receptor signalling cascade R-HSA-354192: Integrin alphaIIb beta3 signaling R-HSA-6785807: Interleukin-4 and 13 signaling R-HSA-109606: Intrinsic Pathway for Apoptosis R-HSA-450604: KSRP (KHSRP) binds and destabilizes mRNA R-HSA-199991: Membrane Trafficking R-HSA-1430728: Metabolism R-HSA-202131: Metabolism of nitric oxide R-HSA-453279: Mitotic G1-G1/S phases R-HSA-187037: NGF signalling via TRKA from the plasma membrane R-HSA-199418: Negative regulation of the PI3K/AKT network R-HSA-109704: PI3K Cascade R-HSA-2219528: PI3K/AKT Signaling in Cancer R-HSA-198203: PI3K/AKT activation R-HSA-6811558: PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-1257604: PIP3 activates AKT signaling R-HSA-109703: PKB-mediated events R-HSA-8849469: PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 R-HSA-76009: Platelet Aggregation (Plug Formation) R-HSA-76002: Platelet activation, signaling and aggregation R-HSA-5357801: Programmed Cell Death R-HSA-8876198: RAB GEFs exchange GTP for GDP on RABs R-HSA-5633007: Regulation of TP53 Activity R-HSA-6804758: Regulation of TP53 Activity through Acetylation R-HSA-6804759: Regulation of TP53 Activity through Association with Co-factors R-HSA-6804757: Regulation of TP53 Degradation R-HSA-6806003: Regulation of TP53 Expression and Degradation R-HSA-186712: Regulation of beta-cell development R-HSA-210745: Regulation of gene expression in beta cells R-HSA-450531: Regulation of mRNA stability by proteins that bind AU-rich elements R-HSA-2730905: Role of LAT2/NTAL/LAB on calcium mobilization R-HSA-162582: Signal Transduction R-HSA-177929: Signaling by EGFR R-HSA-1227986: Signaling by ERBB2 R-HSA-372790: Signaling by GPCR R-HSA-74752: Signaling by Insulin receptor R-HSA-449147: Signaling by Interleukins R-HSA-186797: Signaling by PDGF R-HSA-8848021: Signaling by PTK6 R-HSA-1433557: Signaling by SCF-KIT R-HSA-2404192: Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) R-HSA-194138: Signaling by VEGF R-HSA-195721: Signaling by Wnt R-HSA-983705: Signaling by the B Cell Receptor (BCR) R-HSA-166520: Signalling by NGF R-HSA-201681: TCF dependent signaling in response to WNT R-HSA-5628897: TP53 Regulates Metabolic Genes R-HSA-1474151: Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation R-HSA-3700989: Transcriptional Regulation by TP53 R-HSA-1445148: Translocation of GLUT4 to the plasma membrane R-HSA-4420097: VEGFA-VEGFR2 Pathway R-HSA-5218920: VEGFR2 mediated vascular permeability R-HSA-5653656: Vesicle-mediated transport R-HSA-203615: eNOS activation R-HSA-203765: eNOS activation and regulation R-HSA-165159: mTOR signalling |
Summary | |
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Symbol | AKT1 |
Name | v-akt murine thymoma viral oncogene homolog 1 |
Aliases | RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ...... |
Chromosomal Location | 14q32.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between AKT1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between AKT1 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | AKT1 |
Name | v-akt murine thymoma viral oncogene homolog 1 |
Aliases | RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ...... |
Chromosomal Location | 14q32.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of AKT1 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | AKT1 |
Name | v-akt murine thymoma viral oncogene homolog 1 |
Aliases | RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ...... |
Chromosomal Location | 14q32.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of AKT1 in various data sets.
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Points in the above scatter plot represent the mutation difference of AKT1 in various data sets.
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Summary | |
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Symbol | AKT1 |
Name | v-akt murine thymoma viral oncogene homolog 1 |
Aliases | RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ...... |
Chromosomal Location | 14q32.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AKT1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | AKT1 |
Name | v-akt murine thymoma viral oncogene homolog 1 |
Aliases | RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ...... |
Chromosomal Location | 14q32.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AKT1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AKT1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | AKT1 |
Name | v-akt murine thymoma viral oncogene homolog 1 |
Aliases | RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ...... |
Chromosomal Location | 14q32.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AKT1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | AKT1 |
Name | v-akt murine thymoma viral oncogene homolog 1 |
Aliases | RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ...... |
Chromosomal Location | 14q32.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of AKT1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | AKT1 |
Name | v-akt murine thymoma viral oncogene homolog 1 |
Aliases | RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ...... |
Chromosomal Location | 14q32.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between AKT1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | AKT1 |
Name | v-akt murine thymoma viral oncogene homolog 1 |
Aliases | RAC; PRKBA; AKT; CWS6; PKB-ALPHA; RAC-ALPHA; AKT1m; PKB alpha; RAC-PK-alpha; protein kinase B alpha; proto-o ...... |
Chromosomal Location | 14q32.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting AKT1 collected from DrugBank database. |
Details on drugs targeting AKT1.
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