Summary | |
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Symbol | ALAD |
Name | aminolevulinate dehydratase |
Aliases | ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | - |
Domain |
PF00490 Delta-aminolevulinic acid dehydratase |
Function |
Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. |
Biological Process |
GO:0001101 response to acid chemical GO:0001666 response to hypoxia GO:0002237 response to molecule of bacterial origin GO:0006778 porphyrin-containing compound metabolic process GO:0006779 porphyrin-containing compound biosynthetic process GO:0006782 protoporphyrinogen IX biosynthetic process GO:0006783 heme biosynthetic process GO:0006979 response to oxidative stress GO:0007584 response to nutrient GO:0009314 response to radiation GO:0009635 response to herbicide GO:0009636 response to toxic substance GO:0009991 response to extracellular stimulus GO:0010035 response to inorganic substance GO:0010038 response to metal ion GO:0010039 response to iron ion GO:0010043 response to zinc ion GO:0010044 response to aluminum ion GO:0010212 response to ionizing radiation GO:0010266 response to vitamin B1 GO:0010269 response to selenium ion GO:0010288 response to lead ion GO:0014823 response to activity GO:0031667 response to nutrient levels GO:0031960 response to corticosteroid GO:0032025 response to cobalt ion GO:0032496 response to lipopolysaccharide GO:0033013 tetrapyrrole metabolic process GO:0033014 tetrapyrrole biosynthetic process GO:0033197 response to vitamin E GO:0033273 response to vitamin GO:0036293 response to decreased oxygen levels GO:0042168 heme metabolic process GO:0042440 pigment metabolic process GO:0042493 response to drug GO:0043200 response to amino acid GO:0045471 response to ethanol GO:0046148 pigment biosynthetic process GO:0046501 protoporphyrinogen IX metabolic process GO:0046685 response to arsenic-containing substance GO:0046686 response to cadmium ion GO:0046689 response to mercury ion GO:0048545 response to steroid hormone GO:0051186 cofactor metabolic process GO:0051188 cofactor biosynthetic process GO:0051259 protein oligomerization GO:0051260 protein homooligomerization GO:0051384 response to glucocorticoid GO:0051597 response to methylmercury GO:0070482 response to oxygen levels GO:0070541 response to platinum ion GO:0070542 response to fatty acid GO:0070670 response to interleukin-4 GO:0071241 cellular response to inorganic substance GO:0071248 cellular response to metal ion GO:0071284 cellular response to lead ion GO:0071353 cellular response to interleukin-4 GO:0097305 response to alcohol GO:1990267 response to transition metal nanoparticle |
Molecular Function |
GO:0004655 porphobilinogen synthase activity GO:0016829 lyase activity GO:0016835 carbon-oxygen lyase activity GO:0016836 hydro-lyase activity GO:0032791 lead ion binding |
Cellular Component | - |
KEGG |
hsa00860 Porphyrin and chlorophyll metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-189451: Heme biosynthesis R-HSA-168256: Immune System R-HSA-168249: Innate Immune System R-HSA-1430728: Metabolism R-HSA-189445: Metabolism of porphyrins R-HSA-6798695: Neutrophil degranulation |
Summary | |
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Symbol | ALAD |
Name | aminolevulinate dehydratase |
Aliases | ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ALAD and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ALAD |
Name | aminolevulinate dehydratase |
Aliases | ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ALAD in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ALAD |
Name | aminolevulinate dehydratase |
Aliases | ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ALAD in various data sets.
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Points in the above scatter plot represent the mutation difference of ALAD in various data sets.
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Summary | |
---|---|
Symbol | ALAD |
Name | aminolevulinate dehydratase |
Aliases | ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ALAD. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ALAD |
Name | aminolevulinate dehydratase |
Aliases | ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ALAD. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ALAD. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ALAD |
Name | aminolevulinate dehydratase |
Aliases | ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ALAD. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ALAD |
Name | aminolevulinate dehydratase |
Aliases | ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ALAD expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ALAD |
Name | aminolevulinate dehydratase |
Aliases | ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ALAD and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ALAD |
Name | aminolevulinate dehydratase |
Aliases | ALADH; PBGS; porphobilinogen synthase; aminolevulinate, delta-, dehydratase; Delta-aminolevulinic acid dehyd ...... |
Chromosomal Location | 9q32 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ALAD collected from DrugBank database. |
Details on drugs targeting ALAD.
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