Summary | |
---|---|
Symbol | ALCAM |
Name | activated leukocyte cell adhesion molecule |
Aliases | CD166; MEMD; activated leucocyte cell adhesion molecule; CD antigen CD166; CD166 antigen |
Chromosomal Location | 3q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Cell projection, axon Cell projection, dendrite Note=Detected at the immunological synapse, i.e, at the contact zone between antigen-presenting dendritic cells and T-cells (PubMed:15294938, PubMed:16352806). Colocalizes with CD6 and the TCR/CD3 complex at the immunological synapse (PubMed:15294938). ; SUBCELLULAR LOCATION: Isoform 3: Secreted |
Domain |
PF08205 CD80-like C2-set immunoglobulin domain |
Function |
Cell adhesion molecule that mediates both heterotypic cell-cell contacts via its interaction with CD6, as well as homotypic cell-cell contacts (PubMed:7760007, PubMed:15496415, PubMed:15048703, PubMed:16352806, PubMed:23169771, PubMed:24945728). Promotes T-cell activation and proliferation via its interactions with CD6 (PubMed:15048703, PubMed:16352806, PubMed:24945728). Contributes to the formation and maturation of the immunological synapse via its interactions with CD6 (PubMed:15294938, PubMed:16352806). Mediates homotypic interactions with cells that express ALCAM (PubMed:15496415, PubMed:16352806). Required for normal hematopoietic stem cell engraftment in the bone marrow (PubMed:24740813). Mediates attachment of dendritic cells onto endothelial cells via homotypic interaction (PubMed:23169771). Inhibits endothelial cell migration and promotes endothelial tube formation via homotypic interactions (PubMed:15496415, PubMed:23169771). Required for normal organization of the lymph vessel network. Required for normal hematopoietic stem cell engraftment in the bone marrow. Plays a role in hematopoiesis; required for normal numbers of hematopoietic stem cells in bone marrow. Promotes in vitro osteoblast proliferation and differentiation (By similarity). Promotes neurite extension, axon growth and axon guidance; axons grow preferentially on surfaces that contain ALCAM. Mediates outgrowth and pathfinding for retinal ganglion cell axons (By similarity). ; FUNCTION: Isoform 3: Inhibits activities of membrane-bound isoforms by competing for the same interaction partners. Inhibits cell attachment via homotypic interactions. Promotes endothelial cell migration. Inhibits endothelial cell tube formation. |
Biological Process |
GO:0002250 adaptive immune response GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules GO:0007409 axonogenesis GO:0007411 axon guidance GO:0008045 motor neuron axon guidance GO:0016049 cell growth GO:0031290 retinal ganglion cell axon guidance GO:0048588 developmental cell growth GO:0048667 cell morphogenesis involved in neuron differentiation GO:0048675 axon extension GO:0048846 axon extension involved in axon guidance GO:0060560 developmental growth involved in morphogenesis GO:0061564 axon development GO:0097485 neuron projection guidance GO:0098742 cell-cell adhesion via plasma-membrane adhesion molecules GO:1902284 neuron projection extension involved in neuron projection guidance GO:1990138 neuron projection extension |
Molecular Function | - |
Cellular Component |
GO:0001772 immunological synapse GO:0005924 cell-substrate adherens junction GO:0005925 focal adhesion GO:0009897 external side of plasma membrane GO:0030055 cell-substrate junction GO:0030424 axon GO:0030425 dendrite GO:0042101 T cell receptor complex GO:0043025 neuronal cell body GO:0043235 receptor complex GO:0044297 cell body GO:0098552 side of membrane GO:0098802 plasma membrane receptor complex |
KEGG |
hsa04514 Cell adhesion molecules (CAMs) |
Reactome |
R-HSA-422475: Axon guidance R-HSA-1266738: Developmental Biology R-HSA-373760: L1CAM interactions |
Summary | |
---|---|
Symbol | ALCAM |
Name | activated leukocyte cell adhesion molecule |
Aliases | CD166; MEMD; activated leucocyte cell adhesion molecule; CD antigen CD166; CD166 antigen |
Chromosomal Location | 3q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ALCAM and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ALCAM and anti-tumor immunity in human cancer.
|
Summary | |
---|---|
Symbol | ALCAM |
Name | activated leukocyte cell adhesion molecule |
Aliases | CD166; MEMD; activated leucocyte cell adhesion molecule; CD antigen CD166; CD166 antigen |
Chromosomal Location | 3q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
[ TOP ]
|
|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Statistical results of ALCAM in screening data sets for detecting immune reponses.
|
Summary | |
---|---|
Symbol | ALCAM |
Name | activated leukocyte cell adhesion molecule |
Aliases | CD166; MEMD; activated leucocyte cell adhesion molecule; CD antigen CD166; CD166 antigen |
Chromosomal Location | 3q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ALCAM in various data sets.
|
Points in the above scatter plot represent the mutation difference of ALCAM in various data sets.
|
Summary | |
---|---|
Symbol | ALCAM |
Name | activated leukocyte cell adhesion molecule |
Aliases | CD166; MEMD; activated leucocyte cell adhesion molecule; CD antigen CD166; CD166 antigen |
Chromosomal Location | 3q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ALCAM. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ALCAM |
Name | activated leukocyte cell adhesion molecule |
Aliases | CD166; MEMD; activated leucocyte cell adhesion molecule; CD antigen CD166; CD166 antigen |
Chromosomal Location | 3q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ALCAM. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ALCAM. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ALCAM |
Name | activated leukocyte cell adhesion molecule |
Aliases | CD166; MEMD; activated leucocyte cell adhesion molecule; CD antigen CD166; CD166 antigen |
Chromosomal Location | 3q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ALCAM. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ALCAM |
Name | activated leukocyte cell adhesion molecule |
Aliases | CD166; MEMD; activated leucocyte cell adhesion molecule; CD antigen CD166; CD166 antigen |
Chromosomal Location | 3q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ALCAM expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ALCAM |
Name | activated leukocyte cell adhesion molecule |
Aliases | CD166; MEMD; activated leucocyte cell adhesion molecule; CD antigen CD166; CD166 antigen |
Chromosomal Location | 3q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ALCAM and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ALCAM |
Name | activated leukocyte cell adhesion molecule |
Aliases | CD166; MEMD; activated leucocyte cell adhesion molecule; CD antigen CD166; CD166 antigen |
Chromosomal Location | 3q13.1 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ALCAM collected from DrugBank database. |
There is no record. |