Browse ALDH1A1

Summary
SymbolALDH1A1
Namealdehyde dehydrogenase 1 family, member A1
Aliases RALDH1; retinaldehyde dehydrogenase 1; PUMB1; ALDH1; ALDH-E1; ALDH11; HEL-9; HEL-S-53e; HEL12; ALDH class 1; ......
Chromosomal Location9q21.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm, cytosol
Domain PF00171 Aldehyde dehydrogenase family
Function

Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (PubMed:19296407, PubMed:26373694, PubMed:25450233).

> Gene Ontology
 
Biological Process GO:0001523 retinoid metabolic process
GO:0005996 monosaccharide metabolic process
GO:0006000 fructose metabolic process
GO:0006001 fructose catabolic process
GO:0006066 alcohol metabolic process
GO:0006067 ethanol metabolic process
GO:0006069 ethanol oxidation
GO:0006081 cellular aldehyde metabolic process
GO:0006720 isoprenoid metabolic process
GO:0006721 terpenoid metabolic process
GO:0010817 regulation of hormone levels
GO:0016052 carbohydrate catabolic process
GO:0016101 diterpenoid metabolic process
GO:0019318 hexose metabolic process
GO:0019320 hexose catabolic process
GO:0019682 glyceraldehyde-3-phosphate metabolic process
GO:0034308 primary alcohol metabolic process
GO:0034754 cellular hormone metabolic process
GO:0042445 hormone metabolic process
GO:0042572 retinol metabolic process
GO:0044282 small molecule catabolic process
GO:0044723 single-organism carbohydrate metabolic process
GO:0044724 single-organism carbohydrate catabolic process
GO:0046365 monosaccharide catabolic process
GO:0061624 fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
GO:1901615 organic hydroxy compound metabolic process
Molecular Function GO:0001758 retinal dehydrogenase activity
GO:0004029 aldehyde dehydrogenase (NAD) activity
GO:0005096 GTPase activator activity
GO:0005497 androgen binding
GO:0008047 enzyme activator activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:0018479 benzaldehyde dehydrogenase (NAD+) activity
GO:0030695 GTPase regulator activity
GO:0042562 hormone binding
GO:0060589 nucleoside-triphosphatase regulator activity
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa00830 Retinol metabolism
hsa01100 Metabolic pathways
Reactome R-HSA-211859: Biological oxidations
R-HSA-71384: Ethanol oxidation
R-HSA-70350: Fructose catabolism
R-HSA-5652084: Fructose metabolism
R-HSA-1430728: Metabolism
R-HSA-71387: Metabolism of carbohydrates
R-HSA-211945: Phase 1 - Functionalization of compounds
R-HSA-5365859: RA biosynthesis pathway
R-HSA-162582: Signal Transduction
R-HSA-5362517: Signaling by Retinoic Acid
Summary
SymbolALDH1A1
Namealdehyde dehydrogenase 1 family, member A1
Aliases RALDH1; retinaldehyde dehydrogenase 1; PUMB1; ALDH1; ALDH-E1; ALDH11; HEL-9; HEL-S-53e; HEL12; ALDH class 1; ......
Chromosomal Location9q21.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ALDH1A1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 
  Literatures describing the relation between ALDH1A1 and anti-tumor immunity in human cancer.
PMID Cancer type Relation to immunity Evidence sentences
21856769Breast Carcinoma; Head and Neck Cell Carcinoma; Pancreas CarcinomaPromote immunityAdoptive therapy with ALDH1A1-specific CD8(+) T cells eliminated ALDH(bright) cells, inhibited tumor growth and metastases, or prolonged survival of xenograft-bearing immunodeficient mice.
Summary
SymbolALDH1A1
Namealdehyde dehydrogenase 1 family, member A1
Aliases RALDH1; retinaldehyde dehydrogenase 1; PUMB1; ALDH1; ALDH-E1; ALDH11; HEL-9; HEL-S-53e; HEL12; ALDH class 1; ......
Chromosomal Location9q21.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ALDH1A1 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolALDH1A1
Namealdehyde dehydrogenase 1 family, member A1
Aliases RALDH1; retinaldehyde dehydrogenase 1; PUMB1; ALDH1; ALDH-E1; ALDH11; HEL-9; HEL-S-53e; HEL12; ALDH class 1; ......
Chromosomal Location9q21.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ALDH1A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14120.10.888
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0020.999
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)870.1650.928
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9161.2080.107
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 591.240.491
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 471.1630.578
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.1050.858
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.7090.694
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.820.713
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.8230.768
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.8370.844
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.2030.431
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ALDH1A1 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27733.71.42.30.469
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27593.71.720.532
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211705.9-5.90.447
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131109.1-9.10.458
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolALDH1A1
Namealdehyde dehydrogenase 1 family, member A1
Aliases RALDH1; retinaldehyde dehydrogenase 1; PUMB1; ALDH1; ALDH-E1; ALDH11; HEL-9; HEL-S-53e; HEL12; ALDH class 1; ......
Chromosomal Location9q21.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ALDH1A1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolALDH1A1
Namealdehyde dehydrogenase 1 family, member A1
Aliases RALDH1; retinaldehyde dehydrogenase 1; PUMB1; ALDH1; ALDH-E1; ALDH11; HEL-9; HEL-S-53e; HEL12; ALDH class 1; ......
Chromosomal Location9q21.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ALDH1A1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ALDH1A1.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolALDH1A1
Namealdehyde dehydrogenase 1 family, member A1
Aliases RALDH1; retinaldehyde dehydrogenase 1; PUMB1; ALDH1; ALDH-E1; ALDH11; HEL-9; HEL-S-53e; HEL12; ALDH class 1; ......
Chromosomal Location9q21.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ALDH1A1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolALDH1A1
Namealdehyde dehydrogenase 1 family, member A1
Aliases RALDH1; retinaldehyde dehydrogenase 1; PUMB1; ALDH1; ALDH-E1; ALDH11; HEL-9; HEL-S-53e; HEL12; ALDH class 1; ......
Chromosomal Location9q21.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ALDH1A1 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolALDH1A1
Namealdehyde dehydrogenase 1 family, member A1
Aliases RALDH1; retinaldehyde dehydrogenase 1; PUMB1; ALDH1; ALDH-E1; ALDH11; HEL-9; HEL-S-53e; HEL12; ALDH class 1; ......
Chromosomal Location9q21.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ALDH1A1 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolALDH1A1
Namealdehyde dehydrogenase 1 family, member A1
Aliases RALDH1; retinaldehyde dehydrogenase 1; PUMB1; ALDH1; ALDH-E1; ALDH11; HEL-9; HEL-S-53e; HEL12; ALDH class 1; ......
Chromosomal Location9q21.13
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ALDH1A1 collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting ALDH1A1.
ID Name Drug Type Targets #Targets
DB00157NADHSmall MoleculeAASS, ACADS, ADH1A, ADH1B, ADH1C, ADH4, ADH5, ADH7, AKR1B1, AKR1C1 ......144
DB00162Vitamin ASmall MoleculeALDH1A1, ALDH1A2, ALDH1A3, APOD, DHRS3, DHRS4, HPGDS, LRAT, RBP1, ......18
DB00755TretinoinSmall MoleculeALDH1A1, ALDH1A2, CYP26A1, CYP26B1, CYP26C1, GPRC5A, HPGDS, LCN1, ......19
DB044471,4-DithiothreitolSmall MoleculeALDH1A1, AXIN1, CAMK2A, GSTZ1, HMGCR, LGALS1, MSRA, PPIB, TPI1, TR ......10