Summary | |
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Symbol | ALDH1A2 |
Name | aldehyde dehydrogenase 1 family, member A2 |
Aliases | RALDH2; retinaldehyde dehydrogenase 2; RALDH(II); RALDH2-T; RALDH 2; retinaldehyde-specific dehydrogenase ty ...... |
Chromosomal Location | 15q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm. |
Domain |
PF00171 Aldehyde dehydrogenase family |
Function |
Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Does metabolize octanal and decanal but does not metabolize citral, benzaldehyde, acetaldehyde and propanal efficiently (By similarity). |
Biological Process |
GO:0001101 response to acid chemical GO:0001523 retinoid metabolic process GO:0001654 eye development GO:0001655 urogenital system development GO:0001822 kidney development GO:0001889 liver development GO:0001935 endothelial cell proliferation GO:0001936 regulation of endothelial cell proliferation GO:0002138 retinoic acid biosynthetic process GO:0003002 regionalization GO:0003007 heart morphogenesis GO:0006066 alcohol metabolic process GO:0006081 cellular aldehyde metabolic process GO:0006720 isoprenoid metabolic process GO:0006721 terpenoid metabolic process GO:0006766 vitamin metabolic process GO:0006775 fat-soluble vitamin metabolic process GO:0006776 vitamin A metabolic process GO:0007389 pattern specification process GO:0007423 sensory organ development GO:0007494 midgut development GO:0007507 heart development GO:0007584 response to nutrient GO:0008299 isoprenoid biosynthetic process GO:0009799 specification of symmetry GO:0009855 determination of bilateral symmetry GO:0009952 anterior/posterior pattern specification GO:0009954 proximal/distal pattern formation GO:0009991 response to extracellular stimulus GO:0010817 regulation of hormone levels GO:0014031 mesenchymal cell development GO:0014032 neural crest cell development GO:0014033 neural crest cell differentiation GO:0014706 striated muscle tissue development GO:0016053 organic acid biosynthetic process GO:0016101 diterpenoid metabolic process GO:0016102 diterpenoid biosynthetic process GO:0016114 terpenoid biosynthetic process GO:0016331 morphogenesis of embryonic epithelium GO:0021536 diencephalon development GO:0021700 developmental maturation GO:0021915 neural tube development GO:0021983 pituitary gland development GO:0030323 respiratory tube development GO:0030324 lung development GO:0030326 embryonic limb morphogenesis GO:0030522 intracellular receptor signaling pathway GO:0030900 forebrain development GO:0030902 hindbrain development GO:0031016 pancreas development GO:0031076 embryonic camera-type eye development GO:0031667 response to nutrient levels GO:0032355 response to estradiol GO:0032526 response to retinoic acid GO:0033189 response to vitamin A GO:0033273 response to vitamin GO:0034308 primary alcohol metabolic process GO:0034754 cellular hormone metabolic process GO:0035107 appendage morphogenesis GO:0035108 limb morphogenesis GO:0035113 embryonic appendage morphogenesis GO:0035115 embryonic forelimb morphogenesis GO:0035136 forelimb morphogenesis GO:0035270 endocrine system development GO:0035799 ureter maturation GO:0042445 hormone metabolic process GO:0042572 retinol metabolic process GO:0042573 retinoic acid metabolic process GO:0042574 retinal metabolic process GO:0042904 9-cis-retinoic acid biosynthetic process GO:0042905 9-cis-retinoic acid metabolic process GO:0043010 camera-type eye development GO:0044283 small molecule biosynthetic process GO:0046394 carboxylic acid biosynthetic process GO:0048384 retinoic acid receptor signaling pathway GO:0048565 digestive tract development GO:0048566 embryonic digestive tract development GO:0048568 embryonic organ development GO:0048732 gland development GO:0048736 appendage development GO:0048738 cardiac muscle tissue development GO:0048762 mesenchymal cell differentiation GO:0048799 animal organ maturation GO:0048863 stem cell differentiation GO:0048864 stem cell development GO:0050673 epithelial cell proliferation GO:0050678 regulation of epithelial cell proliferation GO:0055123 digestive system development GO:0060173 limb development GO:0060324 face development GO:0060485 mesenchyme development GO:0060537 muscle tissue development GO:0060541 respiratory system development GO:0061008 hepaticobiliary system development GO:0071229 cellular response to acid chemical GO:0071300 cellular response to retinoic acid GO:0071396 cellular response to lipid GO:0071695 anatomical structure maturation GO:0072001 renal system development GO:0072189 ureter development GO:0072330 monocarboxylic acid biosynthetic process GO:1901615 organic hydroxy compound metabolic process |
Molecular Function |
GO:0001758 retinal dehydrogenase activity GO:0004028 3-chloroallyl aldehyde dehydrogenase activity GO:0004029 aldehyde dehydrogenase (NAD) activity GO:0005501 retinoid binding GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors GO:0016918 retinal binding GO:0019840 isoprenoid binding GO:0019842 vitamin binding |
Cellular Component | - |
KEGG |
hsa00830 Retinol metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-5365859: RA biosynthesis pathway R-HSA-162582: Signal Transduction R-HSA-5362517: Signaling by Retinoic Acid |
Summary | |
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Symbol | ALDH1A2 |
Name | aldehyde dehydrogenase 1 family, member A2 |
Aliases | RALDH2; retinaldehyde dehydrogenase 2; RALDH(II); RALDH2-T; RALDH 2; retinaldehyde-specific dehydrogenase ty ...... |
Chromosomal Location | 15q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ALDH1A2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ALDH1A2 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ALDH1A2 |
Name | aldehyde dehydrogenase 1 family, member A2 |
Aliases | RALDH2; retinaldehyde dehydrogenase 2; RALDH(II); RALDH2-T; RALDH 2; retinaldehyde-specific dehydrogenase ty ...... |
Chromosomal Location | 15q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ALDH1A2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ALDH1A2 |
Name | aldehyde dehydrogenase 1 family, member A2 |
Aliases | RALDH2; retinaldehyde dehydrogenase 2; RALDH(II); RALDH2-T; RALDH 2; retinaldehyde-specific dehydrogenase ty ...... |
Chromosomal Location | 15q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ALDH1A2 in various data sets.
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Points in the above scatter plot represent the mutation difference of ALDH1A2 in various data sets.
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Summary | |
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Symbol | ALDH1A2 |
Name | aldehyde dehydrogenase 1 family, member A2 |
Aliases | RALDH2; retinaldehyde dehydrogenase 2; RALDH(II); RALDH2-T; RALDH 2; retinaldehyde-specific dehydrogenase ty ...... |
Chromosomal Location | 15q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ALDH1A2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ALDH1A2 |
Name | aldehyde dehydrogenase 1 family, member A2 |
Aliases | RALDH2; retinaldehyde dehydrogenase 2; RALDH(II); RALDH2-T; RALDH 2; retinaldehyde-specific dehydrogenase ty ...... |
Chromosomal Location | 15q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ALDH1A2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ALDH1A2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ALDH1A2 |
Name | aldehyde dehydrogenase 1 family, member A2 |
Aliases | RALDH2; retinaldehyde dehydrogenase 2; RALDH(II); RALDH2-T; RALDH 2; retinaldehyde-specific dehydrogenase ty ...... |
Chromosomal Location | 15q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ALDH1A2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ALDH1A2 |
Name | aldehyde dehydrogenase 1 family, member A2 |
Aliases | RALDH2; retinaldehyde dehydrogenase 2; RALDH(II); RALDH2-T; RALDH 2; retinaldehyde-specific dehydrogenase ty ...... |
Chromosomal Location | 15q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ALDH1A2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ALDH1A2 |
Name | aldehyde dehydrogenase 1 family, member A2 |
Aliases | RALDH2; retinaldehyde dehydrogenase 2; RALDH(II); RALDH2-T; RALDH 2; retinaldehyde-specific dehydrogenase ty ...... |
Chromosomal Location | 15q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ALDH1A2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ALDH1A2 |
Name | aldehyde dehydrogenase 1 family, member A2 |
Aliases | RALDH2; retinaldehyde dehydrogenase 2; RALDH(II); RALDH2-T; RALDH 2; retinaldehyde-specific dehydrogenase ty ...... |
Chromosomal Location | 15q21.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ALDH1A2 collected from DrugBank database. |
Details on drugs targeting ALDH1A2.
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