Summary | |
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Symbol | ALDH1L2 |
Name | aldehyde dehydrogenase 1 family, member L2 |
Aliases | FLJ38508; mtFDH; mitochondrial 10-formyltetrahydrofolate dehydrogenase; 10-formyltetrahydrofolate dehydrogen ...... |
Chromosomal Location | 12q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Mitochondrion |
Domain |
PF00171 Aldehyde dehydrogenase family PF02911 Formyl transferase PF00551 Formyl transferase PF00550 Phosphopantetheine attachment site |
Function |
- |
Biological Process |
GO:0006575 cellular modified amino acid metabolic process GO:0006730 one-carbon metabolic process GO:0006732 coenzyme metabolic process GO:0006760 folic acid-containing compound metabolic process GO:0006766 vitamin metabolic process GO:0006767 water-soluble vitamin metabolic process GO:0009109 coenzyme catabolic process GO:0009256 10-formyltetrahydrofolate metabolic process GO:0009258 10-formyltetrahydrofolate catabolic process GO:0009397 folic acid-containing compound catabolic process GO:0019439 aromatic compound catabolic process GO:0042219 cellular modified amino acid catabolic process GO:0042558 pteridine-containing compound metabolic process GO:0042560 pteridine-containing compound catabolic process GO:0044270 cellular nitrogen compound catabolic process GO:0046653 tetrahydrofolate metabolic process GO:0046655 folic acid metabolic process GO:0046700 heterocycle catabolic process GO:0051186 cofactor metabolic process GO:0051187 cofactor catabolic process GO:1901361 organic cyclic compound catabolic process GO:1901565 organonitrogen compound catabolic process |
Molecular Function |
GO:0004029 aldehyde dehydrogenase (NAD) activity GO:0016155 formyltetrahydrofolate dehydrogenase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor GO:0016741 transferase activity, transferring one-carbon groups GO:0016742 hydroxymethyl-, formyl- and related transferase activity GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors GO:0019145 aminobutyraldehyde dehydrogenase activity GO:0047105 4-trimethylammoniobutyraldehyde dehydrogenase activity |
Cellular Component |
GO:0005759 mitochondrial matrix |
KEGG |
hsa00670 One carbon pool by folate |
Reactome |
R-HSA-1430728: Metabolism R-HSA-196757: Metabolism of folate and pterines R-HSA-196854: Metabolism of vitamins and cofactors R-HSA-196849: Metabolism of water-soluble vitamins and cofactors |
Summary | |
---|---|
Symbol | ALDH1L2 |
Name | aldehyde dehydrogenase 1 family, member L2 |
Aliases | FLJ38508; mtFDH; mitochondrial 10-formyltetrahydrofolate dehydrogenase; 10-formyltetrahydrofolate dehydrogen ...... |
Chromosomal Location | 12q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ALDH1L2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ALDH1L2 |
Name | aldehyde dehydrogenase 1 family, member L2 |
Aliases | FLJ38508; mtFDH; mitochondrial 10-formyltetrahydrofolate dehydrogenase; 10-formyltetrahydrofolate dehydrogen ...... |
Chromosomal Location | 12q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ALDH1L2 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ALDH1L2 |
Name | aldehyde dehydrogenase 1 family, member L2 |
Aliases | FLJ38508; mtFDH; mitochondrial 10-formyltetrahydrofolate dehydrogenase; 10-formyltetrahydrofolate dehydrogen ...... |
Chromosomal Location | 12q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ALDH1L2 in various data sets.
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Points in the above scatter plot represent the mutation difference of ALDH1L2 in various data sets.
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Summary | |
---|---|
Symbol | ALDH1L2 |
Name | aldehyde dehydrogenase 1 family, member L2 |
Aliases | FLJ38508; mtFDH; mitochondrial 10-formyltetrahydrofolate dehydrogenase; 10-formyltetrahydrofolate dehydrogen ...... |
Chromosomal Location | 12q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ALDH1L2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ALDH1L2 |
Name | aldehyde dehydrogenase 1 family, member L2 |
Aliases | FLJ38508; mtFDH; mitochondrial 10-formyltetrahydrofolate dehydrogenase; 10-formyltetrahydrofolate dehydrogen ...... |
Chromosomal Location | 12q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ALDH1L2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ALDH1L2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ALDH1L2 |
Name | aldehyde dehydrogenase 1 family, member L2 |
Aliases | FLJ38508; mtFDH; mitochondrial 10-formyltetrahydrofolate dehydrogenase; 10-formyltetrahydrofolate dehydrogen ...... |
Chromosomal Location | 12q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ALDH1L2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ALDH1L2 |
Name | aldehyde dehydrogenase 1 family, member L2 |
Aliases | FLJ38508; mtFDH; mitochondrial 10-formyltetrahydrofolate dehydrogenase; 10-formyltetrahydrofolate dehydrogen ...... |
Chromosomal Location | 12q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ALDH1L2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ALDH1L2 |
Name | aldehyde dehydrogenase 1 family, member L2 |
Aliases | FLJ38508; mtFDH; mitochondrial 10-formyltetrahydrofolate dehydrogenase; 10-formyltetrahydrofolate dehydrogen ...... |
Chromosomal Location | 12q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ALDH1L2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ALDH1L2 |
Name | aldehyde dehydrogenase 1 family, member L2 |
Aliases | FLJ38508; mtFDH; mitochondrial 10-formyltetrahydrofolate dehydrogenase; 10-formyltetrahydrofolate dehydrogen ...... |
Chromosomal Location | 12q23.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ALDH1L2 collected from DrugBank database. |
There is no record. |