Summary | |
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Symbol | ALDH3B2 |
Name | aldehyde dehydrogenase 3 family, member B2 |
Aliases | aldehyde dehydrogenase 8; acetaldehyde dehydrogenase 8; ALDH8; Aldehyde dehydrogenase family 3 member B2 |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Lipid droplet |
Domain |
PF00171 Aldehyde dehydrogenase family |
Function |
Oxidizes medium and long chain aldehydes into non-toxic fatty acids. |
Biological Process |
GO:0006066 alcohol metabolic process GO:0006067 ethanol metabolic process GO:0006068 ethanol catabolic process GO:0006643 membrane lipid metabolic process GO:0006665 sphingolipid metabolic process GO:0030148 sphingolipid biosynthetic process GO:0034308 primary alcohol metabolic process GO:0034310 primary alcohol catabolic process GO:0044282 small molecule catabolic process GO:0046164 alcohol catabolic process GO:0046467 membrane lipid biosynthetic process GO:1901615 organic hydroxy compound metabolic process GO:1901616 organic hydroxy compound catabolic process |
Molecular Function |
GO:0004028 3-chloroallyl aldehyde dehydrogenase activity GO:0004029 aldehyde dehydrogenase (NAD) activity GO:0004030 aldehyde dehydrogenase [NAD(P)+] activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors |
Cellular Component |
GO:0005811 lipid particle |
KEGG |
hsa00010 Glycolysis / Gluconeogenesis hsa00340 Histidine metabolism hsa00350 Tyrosine metabolism hsa00360 Phenylalanine metabolism hsa00410 beta-Alanine metabolism hsa00980 Metabolism of xenobiotics by cytochrome P450 hsa00982 Drug metabolism - cytochrome P450 hsa01100 Metabolic pathways |
Reactome |
R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1660661: Sphingolipid de novo biosynthesis R-HSA-428157: Sphingolipid metabolism |
Summary | |
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Symbol | ALDH3B2 |
Name | aldehyde dehydrogenase 3 family, member B2 |
Aliases | aldehyde dehydrogenase 8; acetaldehyde dehydrogenase 8; ALDH8; Aldehyde dehydrogenase family 3 member B2 |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ALDH3B2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
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Symbol | ALDH3B2 |
Name | aldehyde dehydrogenase 3 family, member B2 |
Aliases | aldehyde dehydrogenase 8; acetaldehyde dehydrogenase 8; ALDH8; Aldehyde dehydrogenase family 3 member B2 |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ALDH3B2 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ALDH3B2 |
Name | aldehyde dehydrogenase 3 family, member B2 |
Aliases | aldehyde dehydrogenase 8; acetaldehyde dehydrogenase 8; ALDH8; Aldehyde dehydrogenase family 3 member B2 |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ALDH3B2 in various data sets.
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Points in the above scatter plot represent the mutation difference of ALDH3B2 in various data sets.
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Summary | |
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Symbol | ALDH3B2 |
Name | aldehyde dehydrogenase 3 family, member B2 |
Aliases | aldehyde dehydrogenase 8; acetaldehyde dehydrogenase 8; ALDH8; Aldehyde dehydrogenase family 3 member B2 |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ALDH3B2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ALDH3B2 |
Name | aldehyde dehydrogenase 3 family, member B2 |
Aliases | aldehyde dehydrogenase 8; acetaldehyde dehydrogenase 8; ALDH8; Aldehyde dehydrogenase family 3 member B2 |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ALDH3B2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ALDH3B2. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ALDH3B2 |
Name | aldehyde dehydrogenase 3 family, member B2 |
Aliases | aldehyde dehydrogenase 8; acetaldehyde dehydrogenase 8; ALDH8; Aldehyde dehydrogenase family 3 member B2 |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ALDH3B2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ALDH3B2 |
Name | aldehyde dehydrogenase 3 family, member B2 |
Aliases | aldehyde dehydrogenase 8; acetaldehyde dehydrogenase 8; ALDH8; Aldehyde dehydrogenase family 3 member B2 |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ALDH3B2 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ALDH3B2 |
Name | aldehyde dehydrogenase 3 family, member B2 |
Aliases | aldehyde dehydrogenase 8; acetaldehyde dehydrogenase 8; ALDH8; Aldehyde dehydrogenase family 3 member B2 |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ALDH3B2 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ALDH3B2 |
Name | aldehyde dehydrogenase 3 family, member B2 |
Aliases | aldehyde dehydrogenase 8; acetaldehyde dehydrogenase 8; ALDH8; Aldehyde dehydrogenase family 3 member B2 |
Chromosomal Location | 11q13.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ALDH3B2 collected from DrugBank database. |
Details on drugs targeting ALDH3B2.
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