Summary | |
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Symbol | ALK |
Name | anaplastic lymphoma receptor tyrosine kinase |
Aliases | CD246; anaplastic lymphoma kinase (Ki-1); NBLST3; CD246 antigen; mutant anaplastic lymphoma kinase; CD antig ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type I membrane protein Note=Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway. |
Domain |
PF00629 MAM domain PF07714 Protein tyrosine kinase |
Function |
Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK. |
Biological Process |
GO:0000187 activation of MAPK activity GO:0018108 peptidyl-tyrosine phosphorylation GO:0018212 peptidyl-tyrosine modification GO:0032147 activation of protein kinase activity GO:0033674 positive regulation of kinase activity GO:0038061 NIK/NF-kappaB signaling GO:0043405 regulation of MAP kinase activity GO:0043406 positive regulation of MAP kinase activity GO:0043410 positive regulation of MAPK cascade GO:0045860 positive regulation of protein kinase activity GO:0046777 protein autophosphorylation GO:0051090 regulation of sequence-specific DNA binding transcription factor activity GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity GO:0051092 positive regulation of NF-kappaB transcription factor activity GO:0071900 regulation of protein serine/threonine kinase activity GO:0071902 positive regulation of protein serine/threonine kinase activity |
Molecular Function |
GO:0004674 protein serine/threonine kinase activity GO:0004702 receptor signaling protein serine/threonine kinase activity GO:0004704 NF-kappaB-inducing kinase activity GO:0004713 protein tyrosine kinase activity GO:0004714 transmembrane receptor protein tyrosine kinase activity GO:0005057 receptor signaling protein activity GO:0019199 transmembrane receptor protein kinase activity |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | ALK |
Name | anaplastic lymphoma receptor tyrosine kinase |
Aliases | CD246; anaplastic lymphoma kinase (Ki-1); NBLST3; CD246 antigen; mutant anaplastic lymphoma kinase; CD antig ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ALK and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between ALK and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | ALK |
Name | anaplastic lymphoma receptor tyrosine kinase |
Aliases | CD246; anaplastic lymphoma kinase (Ki-1); NBLST3; CD246 antigen; mutant anaplastic lymphoma kinase; CD antig ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ALK in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ALK |
Name | anaplastic lymphoma receptor tyrosine kinase |
Aliases | CD246; anaplastic lymphoma kinase (Ki-1); NBLST3; CD246 antigen; mutant anaplastic lymphoma kinase; CD antig ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ALK in various data sets.
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Points in the above scatter plot represent the mutation difference of ALK in various data sets.
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Summary | |
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Symbol | ALK |
Name | anaplastic lymphoma receptor tyrosine kinase |
Aliases | CD246; anaplastic lymphoma kinase (Ki-1); NBLST3; CD246 antigen; mutant anaplastic lymphoma kinase; CD antig ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ALK. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ALK |
Name | anaplastic lymphoma receptor tyrosine kinase |
Aliases | CD246; anaplastic lymphoma kinase (Ki-1); NBLST3; CD246 antigen; mutant anaplastic lymphoma kinase; CD antig ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ALK. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ALK. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ALK |
Name | anaplastic lymphoma receptor tyrosine kinase |
Aliases | CD246; anaplastic lymphoma kinase (Ki-1); NBLST3; CD246 antigen; mutant anaplastic lymphoma kinase; CD antig ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ALK. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | ALK |
Name | anaplastic lymphoma receptor tyrosine kinase |
Aliases | CD246; anaplastic lymphoma kinase (Ki-1); NBLST3; CD246 antigen; mutant anaplastic lymphoma kinase; CD antig ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ALK expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ALK |
Name | anaplastic lymphoma receptor tyrosine kinase |
Aliases | CD246; anaplastic lymphoma kinase (Ki-1); NBLST3; CD246 antigen; mutant anaplastic lymphoma kinase; CD antig ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ALK and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ALK |
Name | anaplastic lymphoma receptor tyrosine kinase |
Aliases | CD246; anaplastic lymphoma kinase (Ki-1); NBLST3; CD246 antigen; mutant anaplastic lymphoma kinase; CD antig ...... |
Chromosomal Location | 2p23 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ALK collected from DrugBank database. |
Details on drugs targeting ALK.
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