Summary | |
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Symbol | ALKBH8 |
Name | alkB homolog 8, tRNA methyltransferase |
Aliases | MGC10235; TRM9; TRMT9; tRNA methyltransferase 9 homolog (S. cerevisiae); alkB, alkylation repair homolog 8 ( ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cytoplasm Nucleus Note=Predominantly cytoplasmic. |
Domain |
PF13532 2OG-Fe(II) oxygenase superfamily PF09004 Domain of unknown function (DUF1891) PF08241 Methyltransferase domain |
Function |
Catalyzes the methylation of 5-carboxymethyl uridine to 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its methyltransferase domain (PubMed:20123966, PubMed:20308323). Catalyzes the last step in the formation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in target tRNA (PubMed:20123966, PubMed:20308323). Has a preference for tRNA(Arg) and tRNA(Glu), and does not bind tRNA(Lys)(PubMed:20308323). Binds tRNA and catalyzes the iron and alpha-ketoglutarate dependent hydroxylation of 5-methylcarboxymethyl uridine at the wobble position of the anticodon loop in tRNA via its dioxygenase domain, giving rise to 5-(S)-methoxycarbonylhydroxymethyluridine; has a preference for tRNA(Gly) (PubMed:21285950). Required for normal survival after DNA damage (PubMed:20308323). May inhibit apoptosis and promote cell survival and angiogenesis (PubMed:19293182). |
Biological Process |
GO:0001510 RNA methylation GO:0002097 tRNA wobble base modification GO:0002098 tRNA wobble uridine modification GO:0006399 tRNA metabolic process GO:0006400 tRNA modification GO:0008033 tRNA processing GO:0009451 RNA modification GO:0030488 tRNA methylation GO:0032259 methylation GO:0034470 ncRNA processing GO:0043414 macromolecule methylation |
Molecular Function |
GO:0000049 tRNA binding GO:0005506 iron ion binding GO:0008168 methyltransferase activity GO:0008173 RNA methyltransferase activity GO:0008175 tRNA methyltransferase activity GO:0008198 ferrous iron binding GO:0016300 tRNA (uracil) methyltransferase activity GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors GO:0016741 transferase activity, transferring one-carbon groups GO:0051213 dioxygenase activity |
Cellular Component | - |
KEGG | - |
Reactome |
R-HSA-74160: Gene Expression R-HSA-6782315: tRNA modification in the nucleus and cytosol R-HSA-72306: tRNA processing |
Summary | |
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Symbol | ALKBH8 |
Name | alkB homolog 8, tRNA methyltransferase |
Aliases | MGC10235; TRM9; TRMT9; tRNA methyltransferase 9 homolog (S. cerevisiae); alkB, alkylation repair homolog 8 ( ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ALKBH8 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ALKBH8 |
Name | alkB homolog 8, tRNA methyltransferase |
Aliases | MGC10235; TRM9; TRMT9; tRNA methyltransferase 9 homolog (S. cerevisiae); alkB, alkylation repair homolog 8 ( ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ALKBH8 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ALKBH8 |
Name | alkB homolog 8, tRNA methyltransferase |
Aliases | MGC10235; TRM9; TRMT9; tRNA methyltransferase 9 homolog (S. cerevisiae); alkB, alkylation repair homolog 8 ( ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ALKBH8 in various data sets.
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Points in the above scatter plot represent the mutation difference of ALKBH8 in various data sets.
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Summary | |
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Symbol | ALKBH8 |
Name | alkB homolog 8, tRNA methyltransferase |
Aliases | MGC10235; TRM9; TRMT9; tRNA methyltransferase 9 homolog (S. cerevisiae); alkB, alkylation repair homolog 8 ( ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ALKBH8. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | ALKBH8 |
Name | alkB homolog 8, tRNA methyltransferase |
Aliases | MGC10235; TRM9; TRMT9; tRNA methyltransferase 9 homolog (S. cerevisiae); alkB, alkylation repair homolog 8 ( ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ALKBH8. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ALKBH8. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ALKBH8 |
Name | alkB homolog 8, tRNA methyltransferase |
Aliases | MGC10235; TRM9; TRMT9; tRNA methyltransferase 9 homolog (S. cerevisiae); alkB, alkylation repair homolog 8 ( ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ALKBH8. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ALKBH8 |
Name | alkB homolog 8, tRNA methyltransferase |
Aliases | MGC10235; TRM9; TRMT9; tRNA methyltransferase 9 homolog (S. cerevisiae); alkB, alkylation repair homolog 8 ( ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ALKBH8 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | ALKBH8 |
Name | alkB homolog 8, tRNA methyltransferase |
Aliases | MGC10235; TRM9; TRMT9; tRNA methyltransferase 9 homolog (S. cerevisiae); alkB, alkylation repair homolog 8 ( ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ALKBH8 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | ALKBH8 |
Name | alkB homolog 8, tRNA methyltransferase |
Aliases | MGC10235; TRM9; TRMT9; tRNA methyltransferase 9 homolog (S. cerevisiae); alkB, alkylation repair homolog 8 ( ...... |
Chromosomal Location | 11q22.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ALKBH8 collected from DrugBank database. |
There is no record. |