Browse AMBP

Summary
SymbolAMBP
Namealpha-1-microglobulin/bikunin precursor
Aliases UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location9q32-q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00014 Kunitz/Bovine pancreatic trypsin inhibitor domain
PF00061 Lipocalin / cytosolic fatty-acid binding protein family
Function

Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization. ; FUNCTION: Trypstatin is a trypsin inhibitor.

> Gene Ontology
 
Biological Process GO:0001933 negative regulation of protein phosphorylation
GO:0002683 negative regulation of immune system process
GO:0006778 porphyrin-containing compound metabolic process
GO:0006787 porphyrin-containing compound catabolic process
GO:0006898 receptor-mediated endocytosis
GO:0007254 JNK cascade
GO:0007565 female pregnancy
GO:0010466 negative regulation of peptidase activity
GO:0010951 negative regulation of endopeptidase activity
GO:0018298 protein-chromophore linkage
GO:0019439 aromatic compound catabolic process
GO:0031098 stress-activated protein kinase signaling cascade
GO:0032872 regulation of stress-activated MAPK cascade
GO:0032873 negative regulation of stress-activated MAPK cascade
GO:0033013 tetrapyrrole metabolic process
GO:0033015 tetrapyrrole catabolic process
GO:0042167 heme catabolic process
GO:0042168 heme metabolic process
GO:0042326 negative regulation of phosphorylation
GO:0042440 pigment metabolic process
GO:0043409 negative regulation of MAPK cascade
GO:0044270 cellular nitrogen compound catabolic process
GO:0044706 multi-multicellular organism process
GO:0045861 negative regulation of proteolysis
GO:0046149 pigment catabolic process
GO:0046328 regulation of JNK cascade
GO:0046329 negative regulation of JNK cascade
GO:0046700 heterocycle catabolic process
GO:0050777 negative regulation of immune response
GO:0051186 cofactor metabolic process
GO:0051187 cofactor catabolic process
GO:0051346 negative regulation of hydrolase activity
GO:0051403 stress-activated MAPK cascade
GO:0052547 regulation of peptidase activity
GO:0052548 regulation of endopeptidase activity
GO:0070302 regulation of stress-activated protein kinase signaling cascade
GO:0070303 negative regulation of stress-activated protein kinase signaling cascade
GO:1901361 organic cyclic compound catabolic process
GO:1901565 organonitrogen compound catabolic process
GO:1902532 negative regulation of intracellular signal transduction
Molecular Function GO:0004857 enzyme inhibitor activity
GO:0004866 endopeptidase inhibitor activity
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005246 calcium channel regulator activity
GO:0008200 ion channel inhibitor activity
GO:0016247 channel regulator activity
GO:0016248 channel inhibitor activity
GO:0019855 calcium channel inhibitor activity
GO:0019862 IgA binding
GO:0019865 immunoglobulin binding
GO:0020037 heme binding
GO:0030414 peptidase inhibitor activity
GO:0046904 calcium oxalate binding
GO:0046906 tetrapyrrole binding
GO:0061134 peptidase regulator activity
GO:0061135 endopeptidase regulator activity
Cellular Component GO:0072562 blood microparticle
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-2173782: Binding and Uptake of Ligands by Scavenger Receptors
R-HSA-2168880: Scavenging of heme from plasma
R-HSA-5653656: Vesicle-mediated transport
Summary
SymbolAMBP
Namealpha-1-microglobulin/bikunin precursor
Aliases UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location9q32-q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between AMBP and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolAMBP
Namealpha-1-microglobulin/bikunin precursor
Aliases UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location9q32-q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of AMBP in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolAMBP
Namealpha-1-microglobulin/bikunin precursor
Aliases UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location9q32-q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of AMBP in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)14121.3290.16
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)650.0970.949
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)872.2570.0727
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160.2760.546
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.170.853
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.8410.441
729033130MelanomaallAnti-PD-1 (nivolumab) 2623-0.480.662
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.4060.821
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.9160.592
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 48-0.0310.989
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.9750.476
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.7840.0291
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of AMBP in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27737.41.460.177
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27597.41.75.70.231
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)211714.3014.30.238
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)131123.1023.10.223
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 9160001
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolAMBP
Namealpha-1-microglobulin/bikunin precursor
Aliases UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location9q32-q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AMBP. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolAMBP
Namealpha-1-microglobulin/bikunin precursor
Aliases UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location9q32-q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AMBP. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AMBP.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolAMBP
Namealpha-1-microglobulin/bikunin precursor
Aliases UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location9q32-q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AMBP. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolAMBP
Namealpha-1-microglobulin/bikunin precursor
Aliases UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location9q32-q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of AMBP expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolAMBP
Namealpha-1-microglobulin/bikunin precursor
Aliases UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location9q32-q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between AMBP and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolAMBP
Namealpha-1-microglobulin/bikunin precursor
Aliases UTI; EDC1; HI30; IATIL; ITILC; growth-inhibiting protein 19; uristatin; complex-forming glycoprotein heterog ......
Chromosomal Location9q32-q33
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting AMBP collected from DrugBank database.
> Drugs from DrugBank database
 

  Details on drugs targeting AMBP.
ID Name Drug Type Targets #Targets
DB00062Human Serum AlbuminBiotechAMBP, APOE, SAA13