Browse ANGPT2

Summary
SymbolANGPT2
Nameangiopoietin 2
Aliases AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location8p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Secreted.
Domain PF00147 Fibrinogen beta and gamma chains
Function

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

> Gene Ontology
 
Biological Process GO:0001525 angiogenesis
GO:0001655 urogenital system development
GO:0001666 response to hypoxia
GO:0001667 ameboidal-type cell migration
GO:0001822 kidney development
GO:0007162 negative regulation of cell adhesion
GO:0007281 germ cell development
GO:0007565 female pregnancy
GO:0009314 response to radiation
GO:0009612 response to mechanical stimulus
GO:0009743 response to carbohydrate
GO:0009746 response to hexose
GO:0009749 response to glucose
GO:0010594 regulation of endothelial cell migration
GO:0010596 negative regulation of endothelial cell migration
GO:0010631 epithelial cell migration
GO:0010632 regulation of epithelial cell migration
GO:0010633 negative regulation of epithelial cell migration
GO:0010810 regulation of cell-substrate adhesion
GO:0010812 negative regulation of cell-substrate adhesion
GO:0014823 response to activity
GO:0016525 negative regulation of angiogenesis
GO:0022412 cellular process involved in reproduction in multicellular organism
GO:0030336 negative regulation of cell migration
GO:0031099 regeneration
GO:0031100 animal organ regeneration
GO:0031589 cell-substrate adhesion
GO:0032102 negative regulation of response to external stimulus
GO:0032835 glomerulus development
GO:0034284 response to monosaccharide
GO:0036293 response to decreased oxygen levels
GO:0040013 negative regulation of locomotion
GO:0043534 blood vessel endothelial cell migration
GO:0043535 regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043542 endothelial cell migration
GO:0044706 multi-multicellular organism process
GO:0045765 regulation of angiogenesis
GO:0045766 positive regulation of angiogenesis
GO:0048014 Tie signaling pathway
GO:0048514 blood vessel morphogenesis
GO:0050900 leukocyte migration
GO:0050918 positive chemotaxis
GO:0050920 regulation of chemotaxis
GO:0050922 negative regulation of chemotaxis
GO:0050926 regulation of positive chemotaxis
GO:0050928 negative regulation of positive chemotaxis
GO:0051271 negative regulation of cellular component movement
GO:0060135 maternal process involved in female pregnancy
GO:0061437 renal system vasculature development
GO:0061440 kidney vasculature development
GO:0070482 response to oxygen levels
GO:0072001 renal system development
GO:0072006 nephron development
GO:0072012 glomerulus vasculature development
GO:0090130 tissue migration
GO:0090132 epithelium migration
GO:1901342 regulation of vasculature development
GO:1901343 negative regulation of vasculature development
GO:1904018 positive regulation of vasculature development
GO:2000146 negative regulation of cell motility
GO:2000181 negative regulation of blood vessel morphogenesis
Molecular Function GO:0030971 receptor tyrosine kinase binding
GO:1990782 protein tyrosine kinase binding
Cellular Component -
> KEGG and Reactome Pathway
 
KEGG hsa04014 Ras signaling pathway
hsa04015 Rap1 signaling pathway
hsa04066 HIF-1 signaling pathway
hsa04151 PI3K-Akt signaling pathway
Reactome R-HSA-202733: Cell surface interactions at the vascular wall
R-HSA-109582: Hemostasis
R-HSA-210993: Tie2 Signaling
Summary
SymbolANGPT2
Nameangiopoietin 2
Aliases AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location8p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ANGPT2 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.

Summary
SymbolANGPT2
Nameangiopoietin 2
Aliases AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location8p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ANGPT2 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolANGPT2
Nameangiopoietin 2
Aliases AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location8p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ANGPT2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-0.8620.0276
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.820.349
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-0.8930.193
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.0480.875
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.0160.993
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47-0.0910.967
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.3970.449
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 1511-0.0870.944
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 11120.9680.467
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.7320.583
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 281.4440.432
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1230.333
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ANGPT2 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 141705.9-5.91
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 41407.1-7.11
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91606.2-6.21
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59011.1-11.11
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470001
1329033130MelanomaallAnti-PD-1 (nivolumab) 382703.7-3.70.415
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 221307.7-7.70.371
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11139.109.10.458
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 512200200.294
Summary
SymbolANGPT2
Nameangiopoietin 2
Aliases AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location8p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ANGPT2. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolANGPT2
Nameangiopoietin 2
Aliases AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location8p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ANGPT2. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ANGPT2.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolANGPT2
Nameangiopoietin 2
Aliases AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location8p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ANGPT2. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolANGPT2
Nameangiopoietin 2
Aliases AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location8p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ANGPT2 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolANGPT2
Nameangiopoietin 2
Aliases AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location8p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ANGPT2 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolANGPT2
Nameangiopoietin 2
Aliases AGPT2; ANG-2; Tie2-ligand; angiopoietin-2B; angiopoietin-2a; Angiopoietin-2
Chromosomal Location8p23
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ANGPT2 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.