Summary | |
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Symbol | ANKH |
Name | ANKH inorganic pyrophosphate transport regulator |
Aliases | HANK; CPPDD; CCAL2; CMDJ; ankylosis, progressive (mouse) homolog; craniometaphyseal dysplasia, Jackson type ...... |
Chromosomal Location | 5p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Membrane Multi-pass membrane protein |
Domain |
PF07260 Progressive ankylosis protein (ANKH) |
Function |
Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter. |
Biological Process |
GO:0001501 skeletal system development GO:0001503 ossification GO:0006817 phosphate ion transport GO:0006820 anion transport GO:0007626 locomotory behavior GO:0015698 inorganic anion transport GO:0030278 regulation of ossification GO:0030282 bone mineralization GO:0030500 regulation of bone mineralization GO:0030505 inorganic diphosphate transport GO:0031214 biomineral tissue development GO:0035435 phosphate ion transmembrane transport GO:0070167 regulation of biomineral tissue development GO:0098656 anion transmembrane transport GO:0098661 inorganic anion transmembrane transport |
Molecular Function |
GO:0005315 inorganic phosphate transmembrane transporter activity GO:0008509 anion transmembrane transporter activity GO:0015103 inorganic anion transmembrane transporter activity GO:0015114 phosphate ion transmembrane transporter activity GO:0015291 secondary active transmembrane transporter activity GO:0022804 active transmembrane transporter activity GO:0030504 inorganic diphosphate transmembrane transporter activity GO:1901677 phosphate transmembrane transporter activity |
Cellular Component |
GO:0019867 outer membrane |
KEGG | - |
Reactome |
R-HSA-5223345: Miscellaneous transport and binding events R-HSA-382551: Transmembrane transport of small molecules |
Summary | |
---|---|
Symbol | ANKH |
Name | ANKH inorganic pyrophosphate transport regulator |
Aliases | HANK; CPPDD; CCAL2; CMDJ; ankylosis, progressive (mouse) homolog; craniometaphyseal dysplasia, Jackson type ...... |
Chromosomal Location | 5p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ANKH and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ANKH |
Name | ANKH inorganic pyrophosphate transport regulator |
Aliases | HANK; CPPDD; CCAL2; CMDJ; ankylosis, progressive (mouse) homolog; craniometaphyseal dysplasia, Jackson type ...... |
Chromosomal Location | 5p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ANKH in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ANKH |
Name | ANKH inorganic pyrophosphate transport regulator |
Aliases | HANK; CPPDD; CCAL2; CMDJ; ankylosis, progressive (mouse) homolog; craniometaphyseal dysplasia, Jackson type ...... |
Chromosomal Location | 5p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ANKH in various data sets.
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Points in the above scatter plot represent the mutation difference of ANKH in various data sets.
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Summary | |
---|---|
Symbol | ANKH |
Name | ANKH inorganic pyrophosphate transport regulator |
Aliases | HANK; CPPDD; CCAL2; CMDJ; ankylosis, progressive (mouse) homolog; craniometaphyseal dysplasia, Jackson type ...... |
Chromosomal Location | 5p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ANKH. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ANKH |
Name | ANKH inorganic pyrophosphate transport regulator |
Aliases | HANK; CPPDD; CCAL2; CMDJ; ankylosis, progressive (mouse) homolog; craniometaphyseal dysplasia, Jackson type ...... |
Chromosomal Location | 5p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ANKH. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ANKH. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ANKH |
Name | ANKH inorganic pyrophosphate transport regulator |
Aliases | HANK; CPPDD; CCAL2; CMDJ; ankylosis, progressive (mouse) homolog; craniometaphyseal dysplasia, Jackson type ...... |
Chromosomal Location | 5p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ANKH. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ANKH |
Name | ANKH inorganic pyrophosphate transport regulator |
Aliases | HANK; CPPDD; CCAL2; CMDJ; ankylosis, progressive (mouse) homolog; craniometaphyseal dysplasia, Jackson type ...... |
Chromosomal Location | 5p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ANKH expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ANKH |
Name | ANKH inorganic pyrophosphate transport regulator |
Aliases | HANK; CPPDD; CCAL2; CMDJ; ankylosis, progressive (mouse) homolog; craniometaphyseal dysplasia, Jackson type ...... |
Chromosomal Location | 5p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ANKH and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ANKH |
Name | ANKH inorganic pyrophosphate transport regulator |
Aliases | HANK; CPPDD; CCAL2; CMDJ; ankylosis, progressive (mouse) homolog; craniometaphyseal dysplasia, Jackson type ...... |
Chromosomal Location | 5p15.2 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ANKH collected from DrugBank database. |
There is no record. |