Summary | |
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Symbol | ANKRD1 |
Name | ankyrin repeat domain 1 (cardiac muscle) |
Aliases | C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ...... |
Chromosomal Location | 10q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus |
Domain |
PF12796 Ankyrin repeats (3 copies) |
Function |
May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. |
Biological Process |
GO:0001666 response to hypoxia GO:0002237 response to molecule of bacterial origin GO:0003007 heart morphogenesis GO:0007507 heart development GO:0007517 muscle organ development GO:0007519 skeletal muscle tissue development GO:0009306 protein secretion GO:0009612 response to mechanical stimulus GO:0010720 positive regulation of cell development GO:0010927 cellular component assembly involved in morphogenesis GO:0010975 regulation of neuron projection development GO:0010976 positive regulation of neuron projection development GO:0014706 striated muscle tissue development GO:0030239 myofibril assembly GO:0030330 DNA damage response, signal transduction by p53 class mediator GO:0031032 actomyosin structure organization GO:0031346 positive regulation of cell projection organization GO:0032496 response to lipopolysaccharide GO:0034612 response to tumor necrosis factor GO:0035690 cellular response to drug GO:0035914 skeletal muscle cell differentiation GO:0035994 response to muscle stretch GO:0036293 response to decreased oxygen levels GO:0036294 cellular response to decreased oxygen levels GO:0042493 response to drug GO:0042692 muscle cell differentiation GO:0042770 signal transduction in response to DNA damage GO:0043516 regulation of DNA damage response, signal transduction by p53 class mediator GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator GO:0045214 sarcomere organization GO:0045666 positive regulation of neuron differentiation GO:0048644 muscle organ morphogenesis GO:0048738 cardiac muscle tissue development GO:0050708 regulation of protein secretion GO:0050714 positive regulation of protein secretion GO:0050769 positive regulation of neurogenesis GO:0051047 positive regulation of secretion GO:0051052 regulation of DNA metabolic process GO:0051053 negative regulation of DNA metabolic process GO:0051146 striated muscle cell differentiation GO:0051222 positive regulation of protein transport GO:0051962 positive regulation of nervous system development GO:0055001 muscle cell development GO:0055002 striated muscle cell development GO:0055008 cardiac muscle tissue morphogenesis GO:0060415 muscle tissue morphogenesis GO:0060537 muscle tissue development GO:0060538 skeletal muscle organ development GO:0070482 response to oxygen levels GO:0070555 response to interleukin-1 GO:0071214 cellular response to abiotic stimulus GO:0071216 cellular response to biotic stimulus GO:0071219 cellular response to molecule of bacterial origin GO:0071222 cellular response to lipopolysaccharide GO:0071260 cellular response to mechanical stimulus GO:0071347 cellular response to interleukin-1 GO:0071356 cellular response to tumor necrosis factor GO:0071396 cellular response to lipid GO:0071407 cellular response to organic cyclic compound GO:0071453 cellular response to oxygen levels GO:0071456 cellular response to hypoxia GO:0071496 cellular response to external stimulus GO:0071559 response to transforming growth factor beta GO:0071560 cellular response to transforming growth factor beta stimulus GO:0071897 DNA biosynthetic process GO:0072331 signal transduction by p53 class mediator GO:1901796 regulation of signal transduction by p53 class mediator GO:1901798 positive regulation of signal transduction by p53 class mediator GO:1903532 positive regulation of secretion by cell GO:1904951 positive regulation of establishment of protein localization GO:2000278 regulation of DNA biosynthetic process GO:2000279 negative regulation of DNA biosynthetic process GO:2001020 regulation of response to DNA damage stimulus GO:2001022 positive regulation of response to DNA damage stimulus |
Molecular Function |
GO:0001076 transcription factor activity, RNA polymerase II transcription factor binding GO:0001085 RNA polymerase II transcription factor binding GO:0001104 RNA polymerase II transcription cofactor activity GO:0001105 RNA polymerase II transcription coactivator activity GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding GO:0002039 p53 binding GO:0003713 transcription coactivator activity GO:0003714 transcription corepressor activity GO:0008134 transcription factor binding GO:0031432 titin binding GO:0042826 histone deacetylase binding GO:0046332 SMAD binding GO:0070412 R-SMAD binding GO:0098811 transcriptional repressor activity, RNA polymerase II activating transcription factor binding |
Cellular Component |
GO:0005667 transcription factor complex GO:0030016 myofibril GO:0030017 sarcomere GO:0031674 I band GO:0043292 contractile fiber GO:0044449 contractile fiber part |
KEGG | - |
Reactome |
R-HSA-535734: Fatty acid, triacylglycerol, and ketone body metabolism R-HSA-1430728: Metabolism R-HSA-556833: Metabolism of lipids and lipoproteins R-HSA-1989781: PPARA activates gene expression R-HSA-400206: Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
Summary | |
---|---|
Symbol | ANKRD1 |
Name | ankyrin repeat domain 1 (cardiac muscle) |
Aliases | C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ...... |
Chromosomal Location | 10q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ANKRD1 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ANKRD1 |
Name | ankyrin repeat domain 1 (cardiac muscle) |
Aliases | C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ...... |
Chromosomal Location | 10q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ANKRD1 in screening data sets for detecting immune reponses.
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Summary | |
---|---|
Symbol | ANKRD1 |
Name | ankyrin repeat domain 1 (cardiac muscle) |
Aliases | C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ...... |
Chromosomal Location | 10q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ANKRD1 in various data sets.
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Points in the above scatter plot represent the mutation difference of ANKRD1 in various data sets.
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Summary | |
---|---|
Symbol | ANKRD1 |
Name | ankyrin repeat domain 1 (cardiac muscle) |
Aliases | C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ...... |
Chromosomal Location | 10q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ANKRD1. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ANKRD1 |
Name | ankyrin repeat domain 1 (cardiac muscle) |
Aliases | C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ...... |
Chromosomal Location | 10q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ANKRD1. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ANKRD1. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
---|---|
Symbol | ANKRD1 |
Name | ankyrin repeat domain 1 (cardiac muscle) |
Aliases | C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ...... |
Chromosomal Location | 10q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ANKRD1. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ANKRD1 |
Name | ankyrin repeat domain 1 (cardiac muscle) |
Aliases | C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ...... |
Chromosomal Location | 10q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ANKRD1 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ANKRD1 |
Name | ankyrin repeat domain 1 (cardiac muscle) |
Aliases | C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ...... |
Chromosomal Location | 10q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ANKRD1 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ANKRD1 |
Name | ankyrin repeat domain 1 (cardiac muscle) |
Aliases | C-193; ALRP; CVARP; MCARP; bA320F15.2; cardiac ankyrin repeat protein; cytokine-inducible gene C-193 protein ...... |
Chromosomal Location | 10q23.33 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ANKRD1 collected from DrugBank database. |
There is no record. |