Summary | |
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Symbol | ANKRD11 |
Name | ankyrin repeat domain 11 |
Aliases | LZ16; T13; ANCO-1; ankyrin repeat-containing cofactor 1; nasopharyngeal carcinoma susceptibility protein; An ...... |
Chromosomal Location | 16q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Nucleus Note=Localizes to chromatin during prometaphase. |
Domain |
PF00023 Ankyrin repeat PF12796 Ankyrin repeats (3 copies) |
Function |
Chromatin regulator which modulates histone acetylation and gene expression in neural precursor cells (By similarity). May recruit histone deacetylases (HDACs) to the p160 coactivators/nuclear receptor complex to inhibit ligand-dependent transactivation (PubMed:15184363). Has a role in proliferation and development of cortical neural precursors (PubMed:25556659). May also regulate bone homeostasis (By similarity). |
Biological Process |
GO:0001501 skeletal system development GO:0001701 in utero embryonic development GO:0001894 tissue homeostasis GO:0010171 body morphogenesis GO:0035264 multicellular organism growth GO:0042475 odontogenesis of dentin-containing tooth GO:0042476 odontogenesis GO:0048705 skeletal system morphogenesis GO:0048871 multicellular organismal homeostasis GO:0060249 anatomical structure homeostasis GO:0060323 head morphogenesis GO:0060324 face development GO:0060325 face morphogenesis GO:0060348 bone development |
Molecular Function | - |
Cellular Component | - |
KEGG | - |
Reactome | - |
Summary | |
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Symbol | ANKRD11 |
Name | ankyrin repeat domain 11 |
Aliases | LZ16; T13; ANCO-1; ankyrin repeat-containing cofactor 1; nasopharyngeal carcinoma susceptibility protein; An ...... |
Chromosomal Location | 16q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between ANKRD11 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
There is no record. |
Summary | |
---|---|
Symbol | ANKRD11 |
Name | ankyrin repeat domain 11 |
Aliases | LZ16; T13; ANCO-1; ankyrin repeat-containing cofactor 1; nasopharyngeal carcinoma susceptibility protein; An ...... |
Chromosomal Location | 16q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of ANKRD11 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | ANKRD11 |
Name | ankyrin repeat domain 11 |
Aliases | LZ16; T13; ANCO-1; ankyrin repeat-containing cofactor 1; nasopharyngeal carcinoma susceptibility protein; An ...... |
Chromosomal Location | 16q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of ANKRD11 in various data sets.
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Points in the above scatter plot represent the mutation difference of ANKRD11 in various data sets.
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Summary | |
---|---|
Symbol | ANKRD11 |
Name | ankyrin repeat domain 11 |
Aliases | LZ16; T13; ANCO-1; ankyrin repeat-containing cofactor 1; nasopharyngeal carcinoma susceptibility protein; An ...... |
Chromosomal Location | 16q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ANKRD11. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
---|---|
Symbol | ANKRD11 |
Name | ankyrin repeat domain 11 |
Aliases | LZ16; T13; ANCO-1; ankyrin repeat-containing cofactor 1; nasopharyngeal carcinoma susceptibility protein; An ...... |
Chromosomal Location | 16q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ANKRD11. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ANKRD11. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | ANKRD11 |
Name | ankyrin repeat domain 11 |
Aliases | LZ16; T13; ANCO-1; ankyrin repeat-containing cofactor 1; nasopharyngeal carcinoma susceptibility protein; An ...... |
Chromosomal Location | 16q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ANKRD11. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
---|---|
Symbol | ANKRD11 |
Name | ankyrin repeat domain 11 |
Aliases | LZ16; T13; ANCO-1; ankyrin repeat-containing cofactor 1; nasopharyngeal carcinoma susceptibility protein; An ...... |
Chromosomal Location | 16q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of ANKRD11 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
---|---|
Symbol | ANKRD11 |
Name | ankyrin repeat domain 11 |
Aliases | LZ16; T13; ANCO-1; ankyrin repeat-containing cofactor 1; nasopharyngeal carcinoma susceptibility protein; An ...... |
Chromosomal Location | 16q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between ANKRD11 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
---|---|
Symbol | ANKRD11 |
Name | ankyrin repeat domain 11 |
Aliases | LZ16; T13; ANCO-1; ankyrin repeat-containing cofactor 1; nasopharyngeal carcinoma susceptibility protein; An ...... |
Chromosomal Location | 16q24.3 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting ANKRD11 collected from DrugBank database. |
There is no record. |