Browse ANXA6

Summary
SymbolANXA6
Nameannexin A6
Aliases ANX6; CBP68; 67 kDa calelectrin; CPB-II; annexin VI (p68); annexin-6; calcium-binding protein p68; calelectr ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Basic function annotation.
> Subcellular Location, Domain and Function
> Gene Ontology
> KEGG and Reactome Pathway
> Subcellular Location, Domain and Function
 
Subcellular Location Cytoplasm Melanosome Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Domain PF00191 Annexin
Function

May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.

> Gene Ontology
 
Biological Process GO:0003012 muscle system process
GO:0006816 calcium ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006875 cellular metal ion homeostasis
GO:0006936 muscle contraction
GO:0006937 regulation of muscle contraction
GO:0044057 regulation of system process
GO:0051259 protein oligomerization
GO:0051260 protein homooligomerization
GO:0051560 mitochondrial calcium ion homeostasis
GO:0055074 calcium ion homeostasis
GO:0070838 divalent metal ion transport
GO:0072503 cellular divalent inorganic cation homeostasis
GO:0072507 divalent inorganic cation homeostasis
GO:0072511 divalent inorganic cation transport
GO:0090257 regulation of muscle system process
Molecular Function GO:0005216 ion channel activity
GO:0005496 steroid binding
GO:0005525 GTP binding
GO:0005543 phospholipid binding
GO:0005544 calcium-dependent phospholipid binding
GO:0015267 channel activity
GO:0015276 ligand-gated ion channel activity
GO:0015485 cholesterol binding
GO:0019001 guanyl nucleotide binding
GO:0022803 passive transmembrane transporter activity
GO:0022834 ligand-gated channel activity
GO:0022836 gated channel activity
GO:0022838 substrate-specific channel activity
GO:0032561 guanyl ribonucleotide binding
GO:0032934 sterol binding
GO:0043178 alcohol binding
GO:0048306 calcium-dependent protein binding
Cellular Component GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005924 cell-substrate adherens junction
GO:0005925 focal adhesion
GO:0010008 endosome membrane
GO:0030055 cell-substrate junction
GO:0031902 late endosome membrane
GO:0042470 melanosome
GO:0044440 endosomal part
GO:0048770 pigment granule
GO:0098852 lytic vacuole membrane
> KEGG and Reactome Pathway
 
KEGG -
Reactome R-HSA-397014: Muscle contraction
R-HSA-445355: Smooth Muscle Contraction
Summary
SymbolANXA6
Nameannexin A6
Aliases ANX6; CBP68; 67 kDa calelectrin; CPB-II; annexin VI (p68); annexin-6; calcium-binding protein p68; calelectr ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Literatures that report relations between ANXA6 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells.
> Text Mining
 

There is no record.
Summary
SymbolANXA6
Nameannexin A6
Aliases ANX6; CBP68; 67 kDa calelectrin; CPB-II; annexin VI (p68); annexin-6; calcium-binding protein p68; calelectr ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets.
> High-throughput Screening
  Statistical results of ANXA6 in screening data sets for detecting immune reponses.
PMID Screening System Cancer Type Cell Line Data Set Statistical Results Relation to immunity
29301958CRISPR-Cas9 melanomaB16F10Pmel-1 T cell NA/NSNA/NS
29301958CRISPR-Cas9 melanomaB16F10OT-1 T cell NA/NSNA/NS
28783722CRISPR-Cas9 melanomaMel6242CT-CRISPR NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX+Anti-PD1 NA/NSNA/NS
28723893CRISPR-Cas9 melanomaB16GVAX NA/NSNA/NS
25691366RNAiBreast cancerMCF7Luc-CTL assay NA/NSNA/NS
24476824shRNAmelanomaB16Primary screen NA/NSNA/NS
24476824shRNAmelanomaB16Secondary screen NA/NSNA/NS
Summary
SymbolANXA6
Nameannexin A6
Aliases ANX6; CBP68; 67 kDa calelectrin; CPB-II; annexin VI (p68); annexin-6; calcium-binding protein p68; calelectr ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets.
> Expression difference between responders and non-responders
> Mutation difference between responders and non-responders
> Expression difference between responders and non-responders
 
Points in the above scatter plot represent the expression difference of ANXA6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes Log2 (Fold Change) P value Anno
126997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)1412-1.0890.0221
226997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)65-0.5230.84
326997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)87-1.5060.446
428552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 916-0.1270.793
528552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 59-0.6340.783
628552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 470.5150.863
729033130MelanomaallAnti-PD-1 (nivolumab) 26230.280.578
829033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 15110.5520.791
929033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 1112-0.0540.982
1029301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 480.3770.87
1129301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 2001
1229301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 280.40.91
1329443960Urothelial cancerallAnti-PD-L1 (atezolizumab) 68230-0.1870.213
> Mutation difference between responders and non-responders
 
Points in the above scatter plot represent the mutation difference of ANXA6 in various data sets.
No PMID Cancer type Group Drug # Res # NRes % Mut/Res % Mut/NRes % Diff (R vs NR) Pval Anno
125765070Non-small cell lung cancer (NSCLC)allAnti-PD-1 (pembrolizumab) 14170001
225765070Non-small cell lung cancer (NSCLC)smokingAnti-PD-1 (pembrolizumab) 1030001
325765070Non-small cell lung cancer (NSCLC)non-smokingAnti-PD-1 (pembrolizumab) 4140001
426359337MelanomaallAnti-CTLA-4 (ipilimumab) 27730001
526359337MelanomaBRAFiAnti-CTLA-4 (ipilimumab) 0140001
626359337Melanomanon-BRAFiAnti-CTLA-4 (ipilimumab) 27590001
726997480MelanomaallAnti-PD-1 (pembrolizumab and nivolumab)21174.804.81
826997480MelanomaMAPKiAnti-PD-1 (pembrolizumab and nivolumab)860001
926997480Melanomanon-MAPKiAnti-PD-1 (pembrolizumab and nivolumab)13117.707.71
1028552987Urothelial cancerallAnti-PD-L1 (atezolizumab) 91611.1011.10.36
1128552987Urothelial cancersmokingAnti-PD-L1 (atezolizumab) 590001
1228552987Urothelial cancernon-smokingAnti-PD-L1 (atezolizumab) 47250250.364
1329033130MelanomaallAnti-PD-1 (nivolumab) 38270001
1429033130MelanomaNIV3-PROGAnti-PD-1 (nivolumab) 22130001
1529033130MelanomaNIV3-NAIVEAnti-PD-1 (nivolumab) 16140001
1629301960Clear cell renal cell carcinoma (ccRCC)allAnti-PD-1 (nivolumab) 11130001
1729301960Clear cell renal cell carcinoma (ccRCC)VEGFRiAnti-PD-1 (nivolumab) 610001
1829301960Clear cell renal cell carcinoma (ccRCC)non-VEGFRiAnti-PD-1 (nivolumab) 5120001
Summary
SymbolANXA6
Nameannexin A6
Aliases ANX6; CBP68; 67 kDa calelectrin; CPB-II; annexin VI (p68); annexin-6; calcium-binding protein p68; calelectr ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of ANXA6. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene.
> Lymphocyte
 
Summary
SymbolANXA6
Nameannexin A6
Aliases ANX6; CBP68; 67 kDa calelectrin; CPB-II; annexin VI (p68); annexin-6; calcium-binding protein p68; calelectr ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of ANXA6. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by ANXA6.
> Immunoinhibitor
> Immunostimulator
> MHC molecule
> Immunoinhibitor
 
> Immunostimulator
 
> MHC molecule
 
Summary
SymbolANXA6
Nameannexin A6
Aliases ANX6; CBP68; 67 kDa calelectrin; CPB-II; annexin VI (p68); annexin-6; calcium-binding protein p68; calelectr ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of ANXA6. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene.
> Chemokine
> Receptor
> Chemokine
 
> Receptor
 
Summary
SymbolANXA6
Nameannexin A6
Aliases ANX6; CBP68; 67 kDa calelectrin; CPB-II; annexin VI (p68); annexin-6; calcium-binding protein p68; calelectr ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Distribution of ANXA6 expression across immune and molecular subtypes.
> Immune subtype
> Molecular subtype
> Immune subtype
 
> Molecular subtype
 
Summary
SymbolANXA6
Nameannexin A6
Aliases ANX6; CBP68; 67 kDa calelectrin; CPB-II; annexin VI (p68); annexin-6; calcium-binding protein p68; calelectr ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Associations between ANXA6 and clinical features.
> Overall survival analysis
> Cancer stage
> Tumor grade
> Overall survival
 
> Stage
 
> Grade
 
Summary
SymbolANXA6
Nameannexin A6
Aliases ANX6; CBP68; 67 kDa calelectrin; CPB-II; annexin VI (p68); annexin-6; calcium-binding protein p68; calelectr ......
Chromosomal Location5q33.1
External Links HGNC, NCBI, Ensembl, Uniprot, GeneCards
Content Drugs targeting ANXA6 collected from DrugBank database.
> Drugs from DrugBank database
 

There is no record.