Summary | |
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Symbol | AOC3 |
Name | amine oxidase, copper containing 3 |
Aliases | VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Basic function annotation. > Subcellular Location, Domain and Function > Gene Ontology > KEGG and Reactome Pathway |
Subcellular Location | Cell membrane Single-pass type II membrane protein |
Domain |
PF01179 Copper amine oxidase PF02727 Copper amine oxidase PF02728 Copper amine oxidase |
Function |
Cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has semicarbazide-sensitive (SSAO) monoamine oxidase activity. May play a role in adipogenesis. |
Biological Process |
GO:0006805 xenobiotic metabolic process GO:0009308 amine metabolic process GO:0009410 response to xenobiotic stimulus GO:0046677 response to antibiotic GO:0071466 cellular response to xenobiotic stimulus |
Molecular Function |
GO:0005507 copper ion binding GO:0008131 primary amine oxidase activity GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor GO:0046982 protein heterodimerization activity GO:0048037 cofactor binding GO:0048038 quinone binding GO:0052593 tryptamine:oxygen oxidoreductase (deaminating) activity GO:0052594 aminoacetone:oxygen oxidoreductase(deaminating) activity GO:0052595 aliphatic-amine oxidase activity GO:0052596 phenethylamine:oxygen oxidoreductase (deaminating) activity |
Cellular Component |
GO:0005769 early endosome GO:0005902 microvillus GO:0098858 actin-based cell projection |
KEGG |
hsa00260 Glycine, serine and threonine metabolism hsa00350 Tyrosine metabolism hsa00360 Phenylalanine metabolism hsa00410 beta-Alanine metabolism hsa01100 Metabolic pathways |
Reactome |
R-HSA-211859: Biological oxidations R-HSA-1430728: Metabolism R-HSA-211945: Phase 1 - Functionalization of compounds |
Summary | |
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Symbol | AOC3 |
Name | amine oxidase, copper containing 3 |
Aliases | VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Literatures that report relations between AOC3 and anti-tumor immunity. The specific mechanism were also collected if the literature reports that a gene specifically promotes or inhibits the infiltration or function of T/NK cells. |
Literatures describing the relation between AOC3 and anti-tumor immunity in human cancer.
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Summary | |
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Symbol | AOC3 |
Name | amine oxidase, copper containing 3 |
Aliases | VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | High-throughput screening data (e.g. CRISPR-Cas9, shRNA and RNAi) for T cell-mediated killing. Genetic screen techniques can identify mechanisms of tumor cell resistance (e.g., PTPN2) and sensitivity (e.g., APLNR) to killing by cytotoxic T cells, the central effectors of anti-tumor immunity. After comprehensively searching, eight groups of screening data sets were collected in the current database. In this tab, users can check whether their selected genes cause resistance or increase sensitivity to T cell-mediated killing in various data sets. |
> High-throughput Screening
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Statistical results of AOC3 in screening data sets for detecting immune reponses.
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Summary | |
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Symbol | AOC3 |
Name | amine oxidase, copper containing 3 |
Aliases | VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Transcriptomic and genomic profiling of pre-treated tumor biopsies from responders and non-responders to immunotherapy. These data were used to identify signatures and mechanisms of response to checkpoint blockade (e.g., anti-PDL1 and anti-PD1). One example is that mutations in the gene PBRM1 benefit clinical survival of patients with clear cell renal cell carcinoma. After comprehensively searching, we collected 5 and 6 of transcriptomic and genomic data sets, respectively. In this tab, users can check whether their selected genes have significant difference of expression or mutation between responders and non-responders in various data sets. > Expression difference between responders and non-responders > Mutation difference between responders and non-responders |
Points in the above scatter plot represent the expression difference of AOC3 in various data sets.
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Points in the above scatter plot represent the mutation difference of AOC3 in various data sets.
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Summary | |
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Symbol | AOC3 |
Name | amine oxidase, copper containing 3 |
Aliases | VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between abundance of tumor-infiltrating lymphocytes (TILs) and expression, copy number, methylation, or mutation of AOC3. The immune-related signatures of 28 TIL types from Charoentong's study, which can be viewed in the download page. For each cancer type, the relative abundance of TILs were inferred by using gene set variation analysis (GSVA) based on gene expression profile. In this tab, users can examine which kinds of TILs might be regulated by the current gene. |
Summary | |
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Symbol | AOC3 |
Name | amine oxidase, copper containing 3 |
Aliases | VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between three kinds of immunomodulators and expression, copy number, methylation, or mutation of AOC3. These immunomo-dulators were collected from Charoentong's study. In this tab, users can examine which immunomodulators might be regulated by AOC3. > Immunoinhibitor > Immunostimulator > MHC molecule |
Summary | |
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Symbol | AOC3 |
Name | amine oxidase, copper containing 3 |
Aliases | VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Relations between chemokines (or receptors) and expression, copy number, methylation, or mutation of AOC3. In this tab, users can examine which chemokines (or receptors) might be regulated by the current gene. > Chemokine > Receptor |
Summary | |
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Symbol | AOC3 |
Name | amine oxidase, copper containing 3 |
Aliases | VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Distribution of AOC3 expression across immune and molecular subtypes. > Immune subtype > Molecular subtype |
Summary | |
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Symbol | AOC3 |
Name | amine oxidase, copper containing 3 |
Aliases | VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content |
Associations between AOC3 and clinical features. > Overall survival analysis > Cancer stage > Tumor grade |
Summary | |
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Symbol | AOC3 |
Name | amine oxidase, copper containing 3 |
Aliases | VAP1; HPAO; VAP-1; vascular adhesion protein 1; amine oxidase, copper containing 3 (vascular adhesion protei ...... |
Chromosomal Location | 17q21 |
External Links | HGNC, NCBI, Ensembl, Uniprot, GeneCards |
Content | Drugs targeting AOC3 collected from DrugBank database. |
Details on drugs targeting AOC3.
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